A5100728359- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- RNA regulation and disease
- Drug Solubulity and Delivery Systems
- Second Language Learning and Teaching
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Foreign Language Teaching Methods
- Data Quality and Management
- Microtubule and mitosis dynamics
- Analytical Chemistry and Chromatography
- Second Language Acquisition and Learning
- RNA modifications and cancer
- Parkinson's Disease Mechanisms and Treatments
- Protein Degradation and Inhibitors
- Chemical and Physical Properties in Aqueous Solutions
- Biotin and Related Studies
- Nuclear Structure and Function
- Biosensors and Analytical Detection
- Insect-Plant Interactions and Control
- Advanced biosensing and bioanalysis techniques
- Analytical Methods in Pharmaceuticals
- Mosquito-borne diseases and control
Zhengzhou University
2025
Nanjing University
2022-2024
Xinyang College of Agriculture and Forestry
2024
Xiamen University
2024
Kunming University of Science and Technology
2019-2023
University of Science and Technology of China
2023
Northwestern Polytechnical University
2022
Air Force Medical University
2022
Fujian Medical University
2018-2021
Henan University Huaihe Hospital and Huaihe Clinical Institute
2020
Mutations of <i>PTEN-induced kinase I</i> (<i>PINK1</i>) cause early-onset Parkinson's disease (PD) with selective neurodegeneration in humans. However, current <i>PINK1</i> knockout mouse and pig models are unable to recapitulate the typical neurodegenerative phenotypes observed PD patients. This suggests that generating non-human primates (NHPs) close humans is essential investigate unique function PINK1 primate brains. Paired single guide RNA (sgRNA)/Cas9-D10A nickases truncated...
ABSTRACT Digestive system tumor, including esophageal gastric intestinal liver pancreatic and cholangiocarcinoma, are the most common tumors worldwide serve as a major cause of tumor‐related death. Cancer stem cells (CSCs) small group in that harbor self‐renewal, differentiation abilities, playing crucial role tumor initiation, progression, metastasis, supposed to be fundamental recurrence after conventional treatment. A comprehensive understanding targeting CSCs is key overcoming tumors. In...
By introducing a therapeutic nucleoside analogue tail to the parent Aptamer-PROTACs, PROTAC-cocktail system (ApTCs-3X) was designed and evaluated.
Non-human primate (NHP) models can closely mimic human physiological functions and are therefore highly valuable in biomedical research. Genome editing is now developing rapidly due to the precision efficiency offered by engineered site-specific endonuclease-based systems, such as transcription activator-like effector nucleases (TALENs) clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein-9 nuclease (Cas9) system. It has been demonstrated that these...
Federated learning (FL) is an appealing paradigm for a global model among distributed clients while preserving data privacy. Driven by the demand high-quality user experiences, evaluating well-trained after FL process crucial. In this paper, we propose closed-loop analytics framework that allows effective evaluation of trained using clients' local data. To address challenges posed system and heterogeneities in process, study goal-directed client selection problem based on selecting subset...
Abstract Sensitive and accurate detection of small molecules from complex matrix has aroused increasing interest in many fields, yet remains an open challenge. Recent years have witnessed a considerable advance aptasensors for diagnostic assay development towards diverse because aptamer is one the most powerful classes molecular receptors with advanced affinity specificity. Herein, we reviewed small‐molecule past five years, focusing on principles to specific applications clinical diagnosis,...
STIP1 Homology and U-Box Containing Protein 1 (STUB1), a ubiquitin E3 ligase initially involved in immune responses, has recently emerged as pleiotropic regulator of different biological systems, including skeletal male reproduction systems. On the latter, homozygous mutation STUB1 gene been identified patients with hypogonadism. However, pattern expression actions testis remains so far unexplored. Herein, we report analyses on testicular human testes impaired spermatogenesis paracrine...
Abstract Mutations of PINK1 cause early-onset Parkinson’s disease (PD) with selective neurodegeneration in humans. However,current knockout mouse and pig models are unable to recapitulate the typical neurodegenerative phenotypes observed PD patients, indicating that it is essential generate non-human primates (NHPs) highly close humans, investigate unique function primate brains. Paired single guide RNA (sgRNA)/Cas9-D10A nickases truncated sgRNA/Cas9, both enabling reduction off-target...