A5008201979- Papaya Research and Applications
- Insect Pest Control Strategies
- Nanoparticles: synthesis and applications
- Traditional and Medicinal Uses of Annonaceae
- Nonlinear Optical Materials Research
- Phytochemistry and Biological Activities
- Photochemistry and Electron Transfer Studies
- Synthesis and biological activity
- Phytochemical compounds biological activities
- Moringa oleifera research and applications
- Meat and Animal Product Quality
- Protein Hydrolysis and Bioactive Peptides
- Ginger and Zingiberaceae research
- GABA and Rice Research
- Cocoa and Sweet Potato Agronomy
- Malaria Research and Control
- Mosquito-borne diseases and control
- Metabolomics and Mass Spectrometry Studies
- Probiotics and Fermented Foods
- Computational Drug Discovery Methods
- Andrographolide Research and Applications
- Organoselenium and organotellurium chemistry
- Cholinesterase and Neurodegenerative Diseases
- Pineapple and bromelain studies
- Hydrogels: synthesis, properties, applications
Ministry of Health
2019-2025
Institute for Medical Research
2018-2025
University of Malaya
2024
National Institutes of Biotechnology Malaysia
2024
National Institutes of Health
2021
Fermentation of milk enhances its nutritional and biological activity through the improvement bioavailability nutrients production bioactive compounds. Coconut was fermented with Lactiplantibacillus plantarum ngue16. The aim this study to evaluate effect fermentation cold storage for 28 days on physicochemical characteristics, shelf life, antioxidant antibacterial activities coconut as well proximate chemical compositions. pH decreased from 4.26 3.92 28th day during storage. viable cell...
Carica papaya leaves have been used for traditional treatment of dengue fever and reported to exhibit an immunomodulatory activity by affecting the level cytokine production in vitro vivo. Due lack adequate vivo evidence disease model, present study was initiated screen identify cytokines affected freeze-dried C. leaf juice (FCPLJ) AG129 mice infected with DEN-2 virus.The were fed orally FCPLJ 3 consecutive days after 24 h virus inoculation. Plasma screened using ProcartaPlex immunoassay....
The aim of this research was to assess the antibacterial and antioxidant properties as well variation in metabolites cell-free supernatant (CFS) produced by lactic acid bacteria (LAB) from local plants: Lactiplantibacillus plantarum ngue16, L. ng10, Enterococcus durans w3, Levilactobacillus brevis w6. tested strains exhibited inhibitory effects against pathogens, including Bacillus cereus, B. subtilis, Cronobacter sakazakii, Escherichia coli, Salmonella Typhimurium, Staphylococcus aureus...
The role of Carica papaya L. leaf juice in immune dysregulation caused by dengue virus infection remains unclear. This study aimed to investigate the immunomodulatory activities freeze-dried C. (FCPLJ) on AG129 mice infected with a clinical DENV-2 (DMOF015) isolate. were orally treated 500 and 1000 mg/kg/day FCPLJ, for three days. Platelet, leukocyte, lymphocyte neutrophil counts microscopically determined. level plasma proinflammatory cytokines was measured multiplex immunoassay. levels...
Background and Aim: Electroejaculation (EE) is widely used for semen collection in bulls but raises concerns about animal welfare due to potential pain stress. The physiological impact of EE on remains a topic debate, with previous studies yielding inconclusive results. This study aims objectively evaluate stress responses subjected using electroencephalography (EEG) alongside hormonal, behavioral, metabolite profiling. Materials Methods: Eight were three replicates, behavioral data...
Network pharmacology, an interdisciplinary field that combines principles from systems biology, and network science, provides a robust framework for exploring the intricate relationship between biological pharmacologically active compounds. This study focuses on herbal medicine Chromolaena odorata, known as “Daun kapal terbang” in Malaysia. plant, renowned its diverse medicinal properties, underwent thorough analysis, revealing anti-inflammatory, antimicrobial, anticancer, antidiabetic,...
Carica papaya leaf juice (CPLJ) was well known for its thrombocytosis activity in rodents and dengue patients. However, the effect of CPLJ treatment on other parameters that could contribute to pathogenesis such as nonstructural protein 1 (NS1) production viremia level have never been highlighted any clinical vivo studies. The aim this study is investigate freeze-dried NS1 levels fever mouse model. infection model established by inoculation non-mouse adapted New Guinea C strain virus (DEN-2)...
Abstract Zebrafish have been utilized for many years as a model animal pharmacological studies on diabetes and obesity. High-fat diet (HFD), streptozotocin alloxan injection, glucose immersion all used to induce obesity in zebrafish. Currently, commonly both male female zebrafish, which may influence the outcomes since zebrafish are biologically different. This study was designed investigate difference between metabolites of diabetic using limonene – natural product has shown several...
Malaria remains a major public health problem worldwide, including in Southeast Asia. Chemotherapeutic agents such as chloroquine (CQ) are effective, but problems with drug resistance and toxicity have necessitated continuous search for new effective antimalarial agents. Here we report on virtual screening of ∼300 diarylpentanoids derivatives, potential Plasmodium falciparum lactate dehydrogenase (PfLDH) inhibitors acceptable drug-like properties. Several molecules binding affinities...
Annona muricata is a common plant used in Africa and South America to manage various types of disease. However, there insufficient toxicological information or published standard available regarding repeated dose animal toxicity data. As part the safety assessment, we exposed Sprague Dawley rats an acute oral A. muricata. The intent current study was use advanced proton nuclear magnetic resonance (1H NMR) serum urinary metabolomics evaluation techniques provide vivo profile leaf ethanol...
The purpose of this study was to profile and identify the endothelial cell biology related genes that are affected by dengue virus infection in liver tissue AG129 mice, with without Carica papaya leaf juice treatment. fever mouse model established intraperitoneal inoculation virus, New Guinea C strain at 2 × 106 PFU. Daily oral administration 1000 mg/kg freeze-dried C. (FCPLJ) done starting from day 1 3 post infection. RNA extracted tissues harvested on 4 expression levels 84 were determined...
Summary Polygonum minus (PM) has a rich traditional usage for health benefits, yet its potential as natural‐based solution obesity management remains unexplored. This study evaluated the antioxidant properties, inhibition of pancreatic lipase and α‐glucosidase activities, metabolite profiles PM aerial extracts harvested at 8, 10, 12 weeks using 1 H NMR‐based metabolomics. exhibited significant enzyme activities. NMR metabolomics unveiled nine major metabolites correlated to bioactivities...
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Background Carica papaya L. is a dioecious plant with leaves known for their medicinal and nutritional value due to rich phytochemical content, including flavonoids. Phytochemical variability arising from maturity sex differences may influence the bioactivity of plant. Objectives This research aims investigate variations flavonoids in C. across different maturation stages impact on accumulation these compounds. Methods An ultra-high performance liquid chromatography–tandem mass spectrometry...
This article presents two types of phytochemical data obtained from Brucea javanica (L.) Merr. roots, a medicinal plant belonging to the Simaroubaceae family. The high-resolution LC-MS dataset comprised chemical profile dichloromethane extract, which was utilised annotate 35 constituents. For annotations, measured spectral were compared with in-silico generated 920 molecular structures previously reported in Simaroubaceae. Indole alkaloids, quassinoids, aliphatics and lignan groups...
This study investigates the influence of substituent groups featuring different electron-donating strength on nonlinear optical (NLO) properties four novel chalcone derivatives (DFC1 – DFC4), combining experimental and theoretical approaches. Spectroscopic characterization was conducted via FT-IR NMR, while thermal stability assessed through TGA. Linear third-order NLO behaviours were determined using a UV–Vis spectrometer Z-scan technique with 532 nm excitation. Theoretical analysis density...
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