A5000483248- Curcumin's Biomedical Applications
- Synthesis and biological activity
- Computational Drug Discovery Methods
- Natural product bioactivities and synthesis
- Phytochemicals and Antioxidant Activities
- Cancer-related Molecular Pathways
- Natural Antidiabetic Agents Studies
- Pain Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Bioactive Compounds and Antitumor Agents
- Carbohydrate Chemistry and Synthesis
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Cholinesterase and Neurodegenerative Diseases
- NF-κB Signaling Pathways
- Cholesterol and Lipid Metabolism
- Developmental Biology and Gene Regulation
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Antimicrobial agents and applications
- Fatty Acid Research and Health
- Inflammatory mediators and NSAID effects
- Cancer, Lipids, and Metabolism
- Synthesis and Reactions of Organic Compounds
- Zebrafish Biomedical Research Applications
University of Malaya
2023-2024
Universiti Putra Malaysia
2014-2022
National Cancer Council Malaysia
2021-2022
Bioscience (China)
2015
Serdang Hospital
2015
Lung cancer (LC) is one of the leading causes cancer-related death. As key features tumor microenvironment, hypoxia conditions are associated with poor prognosis in LC patients. Upregulation hypoxic-induced factor-1α (HIF-1α) leads to activation various factors that contribute increased drug resistance, proliferation, and migration cells. Apurinic/apyrimidinic endonuclease-1 (APEX1) a multi-functional protein regulates several transcription factors, including HIF-1α, growth, oxidative stress...
Targeting lipopolysaccharide (LPS)/toll-like receptor 4 signaling in mononuclear phagocytes has been explored for the treatment of inflammation and inflammation-related disorders. However, only a few key targets have translated into clinical applications. Flavonoids, class ubiquitous plant secondary metabolites, possess privileged scaffold which serves as valuable template designing pharmacologically active compounds directed against diseases with inflammatory components. This perspective...
Copper complexes have the potential to be developed as targeted therapy for cancer because cells take up larger amounts of copper than normal cells. complex Cu(SBCM)2 has been reported induce cell cycle arrest and apoptosis towards triple-negative breast Nevertheless, its effect other subtypes not explored. Therefore, present study was conducted investigate oestrogen-receptor positive MCF-7 Growth inhibition human non-cancerous MCF-10A determined by MTT assay. Morphological changes...
A series of ninety-seven diarylpentanoid derivatives were synthesized and evaluated for their anti-inflammatory activity through NO suppression assay using interferone gamma (IFN-γ)/lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Twelve compounds (9, 25, 28, 43, 63, 64, 81, 83, 84, 86, 88 97) exhibited greater or similar inhibitory in comparison with curcumin (14.7 ± 0.2 µM), notably 97, which demonstrated the most significant IC50 values 4.9 0.3 µM 9.6 0.5 µM, respectively....
The present study was designed to investigate the effect of Ipomoea aquatica extracted using water and methanol at various concentrations on total phenolics, antioxidant capacity, α-glucosidase inhibitory activities. Three I. cultivars were used in this including upland type with narrow leaves (K-11), low-land aquatic types broader shaped (K-25), bamboo-shaped (K-88). results revealed that 70% extract K-11 showed higher phenolic content activities than other two cultivars. phytochemical...
A series of forty-five diarylpentadienone analogues were synthesized and screened for their anti-inflammatory properties. Compound <bold>7d</bold> had potent nitric oxide (NO) activity with an IC<sub>50</sub> value 10.24 μM.
Malaria remains a major public health problem worldwide, including in Southeast Asia. Chemotherapeutic agents such as chloroquine (CQ) are effective, but problems with drug resistance and toxicity have necessitated continuous search for new effective antimalarial agents. Here we report on virtual screening of ∼300 diarylpentanoids derivatives, potential Plasmodium falciparum lactate dehydrogenase (PfLDH) inhibitors acceptable drug-like properties. Several molecules binding affinities...
Chromones are promising for anticancer drug development.
Plants have an extensive diversity of natural phytochemicals that are used as a source medicine. In this study the methanolic leaf extract Callicarpa maingayi together with its increasing polarity soluble fractions hexane (Hex), dichloromethane (DCM), ethyl acetate (EtOAc), n-butanol (n-BuOH), and aqueous (Aq) were examined on antioxidant, acetylcholinesterase (AChE), tyrosinase, α-glucosidase inhibitory activities. Liquid chromatography-diode array detection-electrospray ionization-tandem...
Curcumin, derived from the rhizome Curcuma longa, has been scientifically proven to possess anti-inflammatory activity but is of limited clinical and veterinary use owing its low bioavailability poor solubility. Hence, analogs curcuminoids with improved biological properties have synthesized overcome these limitations. This study aims provide pharmacological basis for 5-(3,4-dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl)penta-2,4-dien-1-one (DHHPD), a synthetic curcuminoid analog, as an...
There is a need to improve and extend the use of clinically approved poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi), including for BRCA wild-type triple-negative breast cancer (TNBC). The demonstration that ruthenium(II) polypyridyl complex (RPC) metallointercalators can rapidly stall DNA replication fork progression provides rationale their combination alongside damage response (DDR) achieve synergism in cells. aim present study was evaluate multi-intercalator [Ru(dppz)2(PIP)]2+...
Abstract A new series of pyrazole, phenylpyrazole, and pyrazoline analogs diarylpentanoids (excluding compounds 3a , 4a 5a 5b ) was pan‐assay interference compounds‐filtered synthesized via the reaction with hydrazine monohydrate phenylhydrazine. Each analog evaluated for its anti‐inflammatory ability suppression nitric oxide (NO) on IFN‐γ/LPS‐activated RAW264.7 macrophage cells. The were also investigated their inhibitory capability toward acetylcholinesterase (AChE) butyrylcholinesterase...
Curcuminoids derived from turmeric rhizome have been reported to exhibit antinociceptive, antioxidant and anti-inflammatory activities. We evaluated the peripheral central antinociceptive activities of 5-(3,4-dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl)penta-2,4-dien-1-one (DHHPD), a novel synthetic curcuminoid analogue at 0.1, 0.3, 1 3 mg/kg (intraperitoneal), through chemical thermal models nociception. The effects DHHPD on vanilloid glutamatergic systems were capsaicin-...
Curcuma mangga is a medicinal plant, and its rhizomes are often used to treat various conditions, such as fever, thorax pain, itching, stomachaches, skin diseases, gout, asthma. Although C. commonly used, information on the relationship between chemical constituents bioactivities of still limited. The extraction solvents have strong effect metabolite profile bioactivity extract. A nuclear magnetic resonance (NMR)-based metabolomics approach was differentiate profiles hexane, chloroform,...