A5017813568- Nanoparticle-Based Drug Delivery
- Erythropoietin and Anemia Treatment
- Protein Interaction Studies and Fluorescence Analysis
- RNA Interference and Gene Delivery
- Metal complexes synthesis and properties
- Lung Cancer Treatments and Mutations
- Nanoplatforms for cancer theranostics
- Genetic factors in colorectal cancer
- Advancements in Transdermal Drug Delivery
- Gut microbiota and health
- Computational Drug Discovery Methods
- Advanced biosensing and bioanalysis techniques
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Lipid Membrane Structure and Behavior
- Virus-based gene therapy research
- Pancreatic and Hepatic Oncology Research
- Mesenchymal stem cell research
- Tannin, Tannase and Anticancer Activities
- RNA modifications and cancer
- Glutathione Transferases and Polymorphisms
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
National Cancer Centre Singapore
2024-2025
Institute of Biomedical Sciences, Academia Sinica
2021-2022
Universiti Putra Malaysia
2017-2019
Bioscience (China)
2019
Copper complexes have the potential to be developed as targeted therapy for cancer because cells take up larger amounts of copper than normal cells. complex Cu(SBCM)2 has been reported induce cell cycle arrest and apoptosis towards triple-negative breast Nevertheless, its effect other subtypes not explored. Therefore, present study was conducted investigate oestrogen-receptor positive MCF-7 Growth inhibition human non-cancerous MCF-10A determined by MTT assay. Morphological changes...
Aptamer-based nanovectors that actively bind to circulating monocytes enhance drug delivery the heart and cancer.
Radiotherapy is the primary treatment modality for most head and neck cancers (HNCs). Despite addition of chemotherapy to radiotherapy enhance its tumoricidal effects, almost a third HNC patients suffer from locoregional relapses. Salvage therapy options such recurrences are limited often suboptimal, partly owing divergent tumor microenvironmental factors underpinning radioresistance. In this study, we utilized combinatorial functionomics approach, Quadratic Phenotypic Optimization Platform...
Abstract Radiotherapy (RT) is an integral modality for the treatment of cancer, with >70% patients requiring RT. However, tumor responses to RT are heterogeneous and influenced by several intrinsic extrinsic factors. Clonal dynamics have identified that in some cancers, radioresistance dominated a process clonal selection adaptation, thereby suggesting cells harbor adaptive pro-survival mechanism To understand mechanisms underpinning this process, we generated four radioresistant (RR)...
Canine mammary gland tumor (CMT) is the most common in intact female dog. Zerumbone (ZER) has promising anticancer properties, but plagued with poor water solubility, absorption, bioavailability, and delivery to target tissues. To solubilize, ZER was loaded into nanostructured lipid carrier (NLC) produce ZER-loaded NLC (ZER-NLC). The objectives of this study were determine antiproliferative effect mode cell death induced by ZER-NLC on a canine adenocarcinoma primary line. There no...
Tamoxifen (TAM) has been used in the treatment of breast cancers and is supplemented with erythropoietin (EPO) to alleviate cancer-related anemia. The purported deleterious effects caused by use EPO chemotherapeutic agents anemia vary across studies remain controversial. nanoparticles as a drug delivery system potential improve specificity anticancer drugs. In this study, we simultaneously incorporated two pharmacological active ingredients one nanocarrier develop EPO-conjugated TAM-loaded...
Nanomedicine is an emerging area in the medical field, particularly treatment of cancers. Nanostructured lipid carrier (NLC) was shown to be a good nanoparticulated for delivery tamoxifen (TAM). In this study, tamoxifen-loaded erythropoietin-coated nanostructured carriers (EPO-TAMNLC) were developed enhance anti-cancer properties and targetability TAM, using EPO as homing ligand receptors (EpoRs) on breast cancer tissue cells. Tamoxifen-loaded NLC (TAMNLC) used comparison. The LA7 cells...
Rationale: Gut microbiota plays a crucial role in cancer development and treatment.Studies show that although the gut is able to promote tumor growth, its presence also improves efficacy of treatment such as immunotherapy.To date, understanding potential impact on other modalities nanomedicine still limited.In this study, we aimed establish relationship between nanomedicine, which can potentially open new path combines modulation along with nanotherapeutics.Methods: Mice bearing 4T1...
137 Background: Resistance to RT remains a clinical challenge, given our limited understanding of the molecular pathways underpinning radioresistance. Here, we investigated for mechanisms linked RR using paired experimental and clinico-molecular HNC PCa datasets discovery validation novel that may be enriched in cancers. Methods: For data, generated (FaDu, HK1) (22Rv1, DU145) cell lines following high-dose X-irradiation (90 Gy 45 fr). Genotypic characterization wildtype (WT) cells was...
Abstract Radiotherapy is an integral modality in treating human cancers, but radioresistance remains a clinical challenge due to the involvement of multiple intrinsic cellular and extrinsic tumour microenvironment factors that govern radiosensitivity. To study are associated with cancer radioresistance, we established 4 radioresistant prostate (22Rv1 DU145) head neck (FaDu HK1) models by irradiating their wild-type parentals 90 Gy, mimicking fractionated radiotherapy schema often using...
Erythropoietin receptors (EPORs) are present not only in erythrocyte precursors but also non-hematopoietic cells including cancer cells. In this study, we determined the effect of fetal bovine serum (FBS) culture medium on EPOR expression and viability estrogen receptor (ER)-positive MCF-7 ER-negative MDA-MB-231 breast Using flow cytometry, showed that inclusion 10% FBS increased expressions viabilities The greater than cells, suggesting presence ERs is associated with poor EPOR. Culture...