A5112324501- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Animal Disease Management and Epidemiology
- RNA and protein synthesis mechanisms
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Enterovirus 71 (EV71) is the major causative agent of hand, foot and mouth disease (HFMD) in children, causing severe clinical outcomes even death. Here, we report an important role highly conserved alanine residue at position 107 capsid protein VP1 (VP1A107) efficient replication EV71. Substitutional mutations VP1A107 significantly diminish viral growth kinetics without significant effect on entry, expression genes production. The results mechanistic studies reveal that regulates cleavage...
Enterovirus-A71 (EV-A71) is the second most common causative agent after coxsackievirus A16 of hand, foot, and mouth disease. The capsids EV-A71 consist 60 copies each four viral structural proteins (VP1-VP4). VP1 highly exposed surface accessible, playing a central role in virus particle assembly, attachment, entry. To gain insight into conserved residues at positions 75, 78, 88 capsid protein these processes, an alanine-scanning analysis was performed using infectious cDNA clone EV-A71....
The rapid emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants that evade immunity elicited by vaccination has posed a global challenge to the control disease 2019 (COVID-19) pandemic. Therefore, developing countermeasures broadly protect against SARS-CoV-2 and related sarbecoviruses is essential. Herein, we have developed lipid nanoparticle (LNP)-encapsulated mRNA (mRNA-LNP) encoding full-length Spike (S) glycoprotein (termed RG001), which confers complete...