A5018039254- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Eosinophilic Disorders and Syndromes
- Acute Myeloid Leukemia Research
- Immune cells in cancer
- COVID-19 Clinical Research Studies
- Chronic Myeloid Leukemia Treatments
- Inflammation biomarkers and pathways
- Historical and modern epidemiology studies
- Genetics, Bioinformatics, and Biomedical Research
- Cell Image Analysis Techniques
- Immunotherapy and Immune Responses
- Hepatitis B Virus Studies
- Sepsis Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Gene expression and cancer classification
- Hepatitis C virus research
- Nutrition, Genetics, and Disease
- Single-cell and spatial transcriptomics
- Immune responses and vaccinations
- Long-Term Effects of COVID-19
- Genetic Associations and Epidemiology
RWTH Aachen University
2023-2025
Centre for Individualised Infection Medicine
2020-2024
Helmholtz Centre for Infection Research
2020-2024
Medizinische Hochschule Hannover
2020-2024
Genomics (United Kingdom)
2024
Center for Experimental and Clinical Infection Research
2020-2022
Objective Hepatitis B virus (HBV)-specific T cells are main effector in the control of HBV infection and hepatitis surface antigen (HBsAg) is suggested to be a critical factor impaired immune response, hallmark chronic infection. In addition HBsAg, other viral markers such as core-related (HBcrAg) available, but their potential association with HBV-specific responses not defined yet, which will important if these used for patient stratification novel therapies aimed at functional cure....
Abstract ‘Severe Acute Respiratory Syndrome - Coronavirus-2’ (SARS-CoV-2) infection causes Coronavirus Disease 2019 (COVID-19), a mild to moderate respiratory tract in the majority of patients. A subset patients, however, progresses severe disease and failure with acute distress syndrome (ARDS). Severe COVID-19 has been associated increased neutrophil counts dysregulated immune responses. The mechanisms protective immunity forms pathogenesis inflammation courses remain largely unclear. Here,...
Humans have a great diversity in phenotypes, influenced by genetic, environmental, nutritional, cultural, and social factors. Understanding the historical trends of physiological traits can shed light on human physiology, as well elucidate factors that influence diseases. Here we built genome-wide polygenic scores for heritable traits, including height, body mass index, lipoprotein concentrations, cardiovascular disease, intelligence, using summary statistics association studies Europeans....
Abstract Epigenetic reprogramming plays an important role in shaping immune memory traits within both innate (trained immunity) and adaptive cells following Bacillus Calmette-Guérin (BCG) vaccination. However, the precise impact of dynamic DNA methylation alterations on immunological responses after BCG vaccination remains inadequately elucidated. To address this knowledge gap, we conducted a comprehensive study by integrating longitudinal analysis systems biology approaches. We established...
Abstract Background: Interferon alpha (IFNa) is approved for the therapy of patients (pts) with polycythemia vera (PV), a subtype myeloproliferative neoplasms (MPN), achieving high hematologic response (HR) rates. A fraction pts also achieve molecular responses (MR), but clonal factors sensitizing MR remain elusive. Methods: We integrated colony formation and differentiation assays single-cell RNA sequencing (scRNAseq) cell genotyping in PV patient-derived cells vs. healthy controls (HC) to...
ABSTRACT Motivation By accounting for variants within measured transcripts, it is possible to evaluate the status of somatic using single-cell RNA-sequencing (scRNA-seq) and characterize their clonality. However, sparsity (very few reads per transcript) or bias in protocols (favoring 3’ ends transcripts) makes chance capturing very unlikely. This can be overcome by targeted sequencing use mitochondrial as natural barcodes clone identification. Currently, available computational tools focus...
Abstract Motivation: By accounting for variants within measured transcripts, it is possible to evaluate the status of somatic using single-cell RNA-sequencing (scRNA-seq) and characterize their clonality. However, sparsity (very few reads per transcript) or bias in protocols (favoring 3’ ends transcripts) makes chance capturing very unlikely. This can be overcome by targeted sequencing use mitochondrial as natural barcodes clone identification. Currently, available computational tools focus...
The vascular niche plays a crucial role in regulating hematopoiesis, and the presence of JAK2V617F endothelial cells (EC) myeloproliferative neoplasms (MPN) underscores its therapeutic significance. Leveraging patient-specific induced pluripotent stem (iPSC) harboring JAK2WT or MPN-driver (heterozygous, HET homozygous, HOM ), we developed scalable 3D bone marrow (BM)-niche mimicking model to study neoplastic vasculogenesis with precise control over cellularity genetics. Global RNA-sequencing...