A5025869893- Bone Tissue Engineering Materials
- Dental materials and restorations
- 3D Printing in Biomedical Research
- Cystic Fibrosis Research Advances
- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- Dental Implant Techniques and Outcomes
- High-Energy Particle Collisions Research
- Neonatal Respiratory Health Research
- Orthopaedic implants and arthroplasty
- Ion channel regulation and function
- Additive Manufacturing and 3D Printing Technologies
- Atomic and Subatomic Physics Research
- Tissue Engineering and Regenerative Medicine
- Asthma and respiratory diseases
- Electrospun Nanofibers in Biomedical Applications
- Cellular Mechanics and Interactions
- Ion Transport and Channel Regulation
- Nuclear physics research studies
- Nuclear Physics and Applications
- Silicon and Solar Cell Technologies
- Quantum, superfluid, helium dynamics
- Polymer Surface Interaction Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Periodontal Regeneration and Treatments
RWTH Aachen University
2016-2025
Max Planck Institute for Chemistry
2005-2025
Universitätsklinikum Aachen
2013-2024
University of Freiburg
1998-2024
Institute for Mobile and Satellite Communication Technology
2023-2024
UCSF Benioff Children's Hospital
2023
European Organization for Nuclear Research
1991-2022
FH Aachen
2000-2021
Faculty of 1000 (United States)
2018
University of Aveiro
2018
A microvalve-based bioprinting system for the manufacturing of high-resolution, multimaterial 3D-structures is reported. Applying a straightforward fluid-dynamics model, shear stress at nozzle site can precisely be controlled. Using this system, broad study on how cell viability and proliferation potential are affected by different levels conducted. Complex, 3D structures printed with high resolution. This work pioneers investigation stress-induced damage in might help to comprehend improve...
The cystic fibrosis transmembrane conductance regulator (CFTR) is an epithelial Cl- channel regulated by protein kinase A. most common mutation in (CF), deletion of Phe-508 (delta F508-CFTR), reduces secretion, but the fatal consequences CF have been difficult to rationalize solely terms this defect. aim study was determine role CFTR HCO3- transport across cell membranes. permeability assessed from measurements intracellular pH [pHi; spectrofluorimetry pH-sensitive dye...
Over the last decade, bioprinting technologies have begun providing important tissue engineering strategies for regenerative medicine and organ transplantation. The major drawback of past approaches has been poor or inadequate material-printing device substrate combinations, as well relatively small size printed construct. Here, we hypothesise that cell-laden hydrogels can be when submerged in perfluorotributylamine (C12F27N), a hydrophobic high-density fluid, these cells placed within...
The mechanical and physicochemical effects of three-dimensional (3D) printable hydrogels on cell behavior are paramount features to consider before manufacturing functional tissues. We hypothesize that besides good printability cytocompatibility a supporting hydrogel for the manufacture individual tissues, it is equally essential beforehand desired tissue (bone, cartilage, fat). In light its application, structure stiffness matrices influence geometry, which in turn impacts differentiation...
Effective vascularization is crucial for three-dimensional (3D) printed hydrogel-cell constructs to efficiently supply cells with oxygen and nutrients. Till date, several hydrogel blends have been developed that allow the in vitro formation of a capillary-like network within gels but comparatively less effort has made improve suitability materials 3D bioprinting process. Therefore, we hypothesize tailored photo-crosslinkable gelatin type I collagen exhibit favorable drop-on-demand printing...
Recent advances in the field of bioprinting have led to development perfusable complex structures. However, most existing printed vascular channels lack composition or key structural and physiological features natural blood vessels they make use more easily printable but less biocompatible hydrogels. Here, we a drop-on-demand technique generate vitro vessel models, consisting continuous endothelium imitating tunica intima, an elastic smooth muscle cell layer mimicking media, surrounding...
Single-spin asymmetries for semi-inclusive pion production in deep-inelastic scattering have been measured the first time. A significant target-spin asymmetry of distribution azimuthal angle straight phi relative to lepton plane was formed pi(+) electroproduction on a longitudinally polarized hydrogen target. The corresponding analyzing power sinstraight moment cross section is 0.022+/-0.005+/-0.003. This result can be interpreted as effect terms involving chiral-odd spin functions...
CAD/CAM milling systems provide a rapid and individual method for the manufacturing of zirconia dental restorations. However, disadvantages these include limited accuracy, possible introduction microscopic cracks, waste material due to principle ‘subtractive process’. The hypothesis this study was that issues can be overcome by novel generative technique, direct inkjet printing. A tailored zirconia-based ceramic suspension with 27 vol% solid content synthesized. printed on conventional, but...
The E885 Collaboration utilized the 1.8GeV/cK− beam line at Alternating Gradient Synchrotron (AGS) to accumulate greater than 10 times world's existing data sample of (K−,K+) events on carbon. A total about 3×105(K−,K+) were collected and analyzed. Ξ hypernuclear states are expected be produced through reaction K−+12→CK++12ΞBe. signal could also result from direct production 11ΛBe+Λ without a distinct intermediate state. measured missing-mass spectrum indicates existence below threshold for...
Genistein, a protein tyrosine kinase inhibitor, activates the cystic fibrosis transmembrane conductance regulator (CFTR) in transfected NIH-3T3 fibroblasts that express CFTR (3T3-CFTR). activity was assayed by 125I efflux and patch clamping cell-attached mode. Both forskolin genistein stimulated activated 9-10 pS anion channel 3T3-CFTR cells but failed to activate mock-transfected cells. unlike 3-isobutyl-1-methylxanthine, did not increase intracellular adenosine 3',5'-cyclic monophosphate...
3D-manufactured hydrogels with precise contours and biological adhesion motifs are interesting candidates in the regenerative medicine field for culture differentiation of human bone-marrow-derived mesenchymal stem cells (MSCs). 3D-bioprinting is a powerful technique to approach one step closer native organization cells. This study investigates effect incorporation collagen type I 3D-bioprinted polysaccharide-based modulation cell morphology, osteogenic remodeling potential, mineralization....
In vitro multilayered tissues with mimetic architectures resembling native are valuable tools for application in medical research. this study, an advanced bioprinting strategy is presented aligning collagen fibers contained functional bioinks. Streptavidin-coated iron nanoparticles embedded printable bioinks varying concentrations of low gelling temperature agarose and type I collagen. By applying a straightforward magnetic-based mechanism hydrogels during bioprinting, it possible to align...
Abstract Corneal transplantation is the treatment of choice for patients with advanced corneal diseases. However, outcome may be affected by graft rejection, high associated costs, surgical expertise, and most importantly worldwide donor shortage. In recent years, bioprinting has emerged as an alternative method fabricating tissue equivalents using autologous cells architecture resembling native tissue. this study, we propose a freeform cell‐friendly drop‐on‐demand strategy creating stromal...
Since large bone defects cannot be healed by the body itself, continuous effort is put into development of 3D scaffolds for tissue engineering. One method to fabricate such selective laser sintering (SLS). However, there a lack solvent-free prepared microparticles suitable SLS. Hence, aim this study was develop polylactide/calcium carbonate composite powder with tailored material properties Four powders composition approximately 75 wt% polylactide (PLLA as well PDLLA) and 25 calcium...
Three-dimensional (3D) bioprinting is a promising technology for manufacturing cell-laden tissue-engineered constructs. Larger tissue substitutes, however, require vascularized network to ensure nutrition supply. Therefore, tailored bioinks combining 3D printability and cell-induced vascularization are needed. We hypothesize that hydrogel blends made of agarose-type I collagen agarose-fibrinogen printable will allow the formation capillary-like structures by human umbilical vein endothelial...
In recent years, novel biofabrication technologies have enabled the rapid manufacture of hydrogel-cell suspensions into tissue-imitating constructs. The development materials for still remains a challenge due to gap between contradicting requirements such as three-dimensional printability and optimal cytocompatibility. We hypothesise that blending different hydrogels could lead material with favourable biological printing properties. our work, we combined agarose type I collagen in order...
Abstract This study introduces a thermogelling bioink based on carboxylated agarose (CA) for bioprinting of mechanically defined microenvironments mimicking natural tissues. In CA system, by adjusting the degree carboxylation, elastic modulus printed gels can be tuned over several orders magnitudes (5–230 Pa) while ensuring almost no change to shear viscosity (10–17 mPa) solution; thus enabling fabrication 3D structures made different mechanical domains under identical printing parameters...
Abstract New particle formation (NPF) in the tropical upper troposphere is a globally important source of atmospheric aerosols 1–4 . It known to occur over Amazon basin, but nucleation mechanism and chemical precursors have yet be identified 2 Here we present comprehensive situ aircraft measurements showing that extremely low-volatile oxidation products isoprene, particularly certain organonitrates, drive NPF Amazonian troposphere. The organonitrates originate from OH-initiated isoprene...