A5006944256- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Erythrocyte Function and Pathophysiology
- Platelet Disorders and Treatments
- Sepsis Diagnosis and Treatment
- Complement system in diseases
- Acute Kidney Injury Research
- Neonatal Health and Biochemistry
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Methemoglobinemia and Tumor Lysis Syndrome
- Hemophilia Treatment and Research
- Renal Diseases and Glomerulopathies
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Kruppel-like factors research
- Curcumin's Biomedical Applications
- Congenital Diaphragmatic Hernia Studies
- Genomics and Rare Diseases
- T-cell and Retrovirus Studies
- Trace Elements in Health
Siriraj Hospital
2017-2024
Mahidol University
2017-2024
Abstract Crovalimab is a novel C5 complement inhibitor that enables rapid and sustained inhibition with subcutaneous, low‐volume self‐administration every 4 weeks. COMMODORE 2 (NCT04434092) global, randomized, open‐label, multicenter, phase 3 trial evaluating the non‐inferiority of crovalimab versus eculizumab in patients paroxysmal nocturnal hemoglobinuria not previously treated inhibition. inhibitor‐naive lactate dehydrogenase (LDH) ≥2 × upper limit normal (ULN) were randomized 2:1 to or...
Thalassemia is a common genetic disease in Southeast Asia. Red blood cell (RBC) transfusion an essential treatment for severe forms of thalassemia. We performed study to demonstrate RBC alloimmunization and other transfusion-related complications patients with transfusion-dependent thalassemia (TDT).A multi-center web-based registry TDT was conducted eight medical centers across Thailand. information, therapy, were collected. Factors associated each complication demonstrated using the...
Objectives:: To investigate the efficacy and safety of second-line treatment in Thai patients with primary warm-type autoimmune hemolytic anemia (AIHA) that failed corticosteroid treatment.Methods:: This descriptive retrospective study included aged >14 years who were diagnosed treated for AIHA at Division Hematology, Department Medicine, Faculty Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, during January 2007 to December 2016. All 54 first-line after which was...
In heterozygous females, X-inactivation causes a change in glucose-6-phosphate dehydrogenase (G6PD) activity from normal to deficient. Most G6PD screening tests are used accurately diagnose hemizygous males, but they less reliable for diagnosing females. This study established flow cytometric cut-off values of deficiency males and or homozygous We studied 205 (125 80 males) leftover blood samples quantitative methemoglobin reduction (MR) screening. gene mutations determined by multiplex...
Clinical manifestations of patients with Hemoglobin E/beta-thalassemia vary from mild to severe phenotypes despite exhibiting the same genotype. Studies have partially identified genetic modifiers. We aimed study association between rare variants in protein-coding regions and clinical severity Thai patients.From April November 2018, a case-control was conducted based on information DNA samples collected hemoglobin over age four years. Cases were symptoms, while symptoms acted as controls....
Diagnosis of thrombotic microangiopathy (TMA) relies on microscopic schistocyte determination by an experienced microscopist. In addition, schistocytes can be found in non-TMA-related disorders such as thalassaemia. We aimed to compare the accuracy automated haematology analyser Sysmex XN-3000 for detection, that microscopy approach, patients suspected having schistocytosis.Consecutive blood samples were collected between April 2016 and March 2017 at Siriraj Hospital, Mahidol University,...
Abstract Introduction Management of transfusion‐dependent thalassemia (TDT) can be challenging due to numerous potential disease‐related complications and comorbidities in particular age groups. The objective this study was report thalassemia‐related risk factors pediatric, adolescent, young adult patients with TDT. Methods A multicenter web‐based registry conducted TDT aged 25 years younger from eight university hospitals covering all parts Thailand. Factors significantly associated each...
Summary Haemoglobin (Hb) H disease and HbH with co‐inherited HbE mutation are the most prevalent forms of α‐thalassaemia in Southeast Asia. Data were limited when comparing clinical phenotypes between these two patient groups. We conducted a Thai multicentre study enrolled 588 patients [median (IQR) age 13.0 (6.7–20.3) years], including those deletional ( n = 47) without 187) non‐deletional 101) 253) mutation. Patients suffered more severe manifestations than without. This observation was...
Abstract Based on Thalassemia International Federation clinical practice guidelines (CPG) for non-transfusion dependent and transfusion thalassemia, several measures should be routinely implemented such as monitoring surveillance of thalassemia related complications early detection proper management. To evaluate the prevalence performance routine during 2 periods; before after published CPGs (2012–2014 vs 2015–2017), data from 524 adult patients attended at Siriraj hospital were compared...
Background: Acquired factor X deficiency is an uncommon condition, and affected individuals have severe spontaneous bleeding. The associated conditions include malignancy, infection, burn, inflammatory bowel disease. Many previous studies reported association between lymphoproliferative disease disappearance. Amyloid deposition causing absorption was the most common mechanism. Here, we report a case of stage IV lymphoplasmacytic lymphoma (LPL) with who successfully treated bendamustine plus...