Camellia oil is commonly used as an adjuvant in medicine. It rich monounsaturated fatty acids, vitamin E, and phytochemicals. The objective of this study was to examine effects camellia consumption on oxidative stress, low-density lipoprotein-cholesterol (LDL-C) oxidation, inflammatory markers hypercholesterolemic subjects. design a randomized, single-blind controlled trial. Women with hypercholesterolemia (n = 50) were randomly divided into two groups. treatment group 25) provided...

Studies on the antioxidant treatment for thalassemia have reported variable outcomes. However, of with a combination hydrophobic and hydrophilic antioxidants an iron chelator has not been studied. This study investigated effects cocktails β -thalassemia/hemoglobin E (HbE), which is most common form -thalassemia in Southeast Asia. Sixty patients were divided into two groups receiving N-acetylcysteine, deferiprone, either curcuminoids (CUR) or vitamin (Vit-E), their hematological parameters,...

Abstract α‐ and γ‐Mangostin are the most abundant prenylated xanthones present in fruit of mangosteen tree. These compounds have been reported to possess numerous bioactivities that provided impetus for use products as nutraceuticals functional foods dietary supplements. The health‐promoting benefits dependent on delivery target tissues. Here, we used simulated digestion Caco‐2 cells investigate digestive stability, bioaccessibility, intestinal cell transport γ‐ mangostin. Recovery...

β ‐thalassemia/Hb E is known to cause oxidative stress induced by iron overload. The glutathione system the major endogenous antioxidant that protects animal cells from damage. This study aimed determine effect of disease state and splenectomy on redox status expressed whole blood (GSH)/glutathione disulfide (GSSG) also evaluate glutathione‐related responses oxidation in patients. Twenty‐seven normal subjects 25 patients were recruited was collected. GSH/GSSG ratio, activities enzymes,...

Oxidative stress in thalassemia is caused by secondary iron overload and stems from blood transfusion increased uptake. In this study, we hypothesized that levels of o- m-tyrosine, products hydroxyl radical attack on phenylalanine, would be elevated β-thalassemia (intermediate). This study represents the first report which specific markers protein oxidative damage have been quantified thalassemia. We used GC/MS to assay m-tyrosine at femtomole level using only a few microliters plasma....

In thalassemia patients, iron overload can stimulate lipid peroxidation (LPO), thereby generating miscoding DNA adducts. Adducted was measured in the lymphocytes of beta-Thal/Hb E patients and healthy controls organs thalassemic mice. epsilondA, epsilondC M(1)dG residues were quantified by (32)P-postlabeling-TLC/HPLC. levels lymphocyte from 4 times as high controls, while increase epsilondA not significant. accumulated liver mice having >2.7 mg Fe/g tissue dry weight; adducts highly...

Abstract Thalassemia is a group of genetic disorders resulting from different mutations in the globin gene complex and leading to an imbalance synthesis. Unmatched chains are less stable susceptible oxidation. Patients with β‐thalassemia/HbE prone increased oxidative stress as indicated by lipid peroxidation product, malondialdehyde (MDA), partly because presence iron form heme hemichromes released excess deposition various tissues. The level antioxidant such glutathione markedly decreased...

Abstract Background Dysregulation of adipocytokines, inflammatory cytokines and oxidative stress are associated with the pathogenesis obesity-related complications. This study aimed to evaluate effect a group-based lifestyle modification program on cytokines, status arterial stiffness in obese youth. Methods A 1-year weight-reduction was conducted. The consisted initial hospitalization five outpatient sessions held at 1, 2, 3, 6 9 months. Pre- post-intervention measurements included...

Objective: Iron overload and oxidative stress are the major causes of serious complications mortality in thalassemic patients. Our previous work supports synergistic effects antioxidant cocktails (curcuminoids or vitamin E, N-acetylcysteine, deferiprone) treatment β-thalassemia/Hb E This further 2-DE-based proteomic study aimed to identify plasma proteins that expressed differentially response cocktails.Methods: Frozen samples ten normal subjects patients at three-time points (baseline,...

A bstract : novel C57BL/6 transgenic murine model of HbE has been developed, and the heterotetrameric ( m α 2 h β E ) hemoglobin shows significant complementation mild thalassemia phenotype in double heterozygous (β m+ m− , hE homozygous knockout mice with 100% hemoglobin. Lethal β‐thalassemic rescued by transgenes mimic β‐thalassemia/HbE human. Although anemia was not pronounced, other hematologic parameters were abnormally similar to β‐knockout mice. Flow cytometric study revealed a highly...

Objective: To evaluate the volume of blood transfusion requirements as well hemolytic and oxidative biochemical variables in transfusion-dependent β-thalassemia patients supplemented with vitamin E.Material Methods: A prospective, double-blind, randomized, placebo-controlled, crossover study was undertaken between December, 2012 September, 2014 Pediatric Clinic Songklanagarind Hospital. The participants were major Hb E/β-thalassemia aged 5 18 years. random allocation sequence generated to...

β°‐Thalassaemia/Hb E disease is the most frequent β‐thalassaemia in Thailand. However, patients have a varying degree of anaemia. The difference severity attributed to differential accumulation unpaired α‐globin chains, which net result biosynthesis and catabolism. Turnover newly synthesized globin chains reticulocytes from β°‐thalassaemia/Hb was determined. Proteolysis ATP‐independent degraded only 10–15% radiolabelled during 4‐h incubation period at 37 °C there no turnover subjects with...

Thalassemia is a group of genetic disorders resulting from different mutations in the globin gene clusters and leading to an imbalance synthesis. Unpaired chains are less stable susceptible oxidation. Patients with beta‐thalassemia/HbE (β‐thal/HbE) prone increase oxidative stress as indicated by increased lipid peroxidation protein Curcumin, strong antioxidant iron chelator, has been shown decrease β‐thal/HbE patients. In this study, effect curcumin on plasma expression was investigated...

a‐ and g‐Mangostin (MG) are the most abundant prenylated xanthones present in fruit of mangosteen tree. These compounds have been reported to possess numerous bioactivities that provided impetus for use products functional foods dietary supplements. The health‐promoting benefits dependent on delivery target tissues. Here, we used simulated digestion Caco‐2 cells investigate digestive stability, bioaccessibility intestinal cell transport metabolism α‐ γ‐MG. Transfer g‐MG aqueous fraction...

Zinc is an important element in numerous transcription factors, antioxidant enzymes, and DNA repair proteins. Leukemia a neoplastic disease that susceptible to oxidative stress alteration of essential elements. This study was conducted determine the status zinc damage pediatric patients with acute lymphoblastic leukemia (ALL). Ten patients, aged 1–12 years, who were newly diagnosed ALL 10 age‐matched healthy children (as controls) recruited study. Plasma 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG)...