A5047756073- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Neurological disorders and treatments
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Function and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Atherosclerosis and Cardiovascular Diseases
- Heart Rate Variability and Autonomic Control
- Cardiovascular Disease and Adiposity
- Genetic Neurodegenerative Diseases
- Blood Pressure and Hypertension Studies
- Parkinson's Disease Mechanisms and Treatments
- Cardiovascular Effects of Exercise
- Acute Lymphoblastic Leukemia research
- Systemic Sclerosis and Related Diseases
- Cardiac Valve Diseases and Treatments
- Advanced MRI Techniques and Applications
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Cardiomyopathy and Myosin Studies
Bayer (Germany)
2024
Agostino Gemelli University Polyclinic
2020-2023
University of Molise
2020-2023
Università Cattolica del Sacro Cuore
2004-2022
University of the Sacred Heart
2007-2022
Global Earthquake Model
2022
Policlinico S.Orsola-Malpighi
2020
University of Bologna
2020
Ospedale dei Pellegrini
2020
Azienda Ospedaliera Universitaria Università degli Studi della Campania Luigi Vanvitelli
2020
Electrical storm (ES) caused by recurrent episodes of ventricular tachycardia (VT) can cause sudden death in patients with implantable cardioverter-defibrillators and adversely affects prognosis survivors. Catheter ablation has been proposed for treating ES, but its long-term effect a large population never verified.Ninety-five consecutive coronary artery disease (72 patients), idiopathic dilated cardiomyopathy (10 arrhythmogenic right dysplasia/cardiomyopathy (13 patients) undergoing...
Background: Optimal timing for catheter ablation of ventricular tachycardia is an important unresolved issue. There are no randomized trials evaluating the benefit after first implantable cardioverter defibrillator (ICD) shock. Methods: We conducted a 2-phase, prospective, multicenter, clinical trial. Patients with ischemic or nonischemic dilated cardiomyopathy and primary secondary prevention indication ICD were enrolled in initial observational phase until appropriate shock (phase A)....
Aim Telemonitoring (TM) is a safe and efficient monitoring system for internal cardioverter defibrillator device (ICD) recipients. TM has been used to track info on the clinical status of heart failure patients treated by ICD and/or cardiac resynchronisation therapy (CRT-D). The aim this study was investigate impact outcomes in population CRT-D with failure. Methods In multicentre, randomised study, chronic failure, New York Heart Association (NYHA) functional class II or III, left bundle...
In patients with type 2 diabetes mellitus (T2DM) the vaso-vagal syncope (VVS) recurrence could be due to alteration of autonomic system function, evaluated by heart rate variability (HRV), and 123I-metaiodobenzylguanidine (123I-mIBG) myocardial scintigraphy indexes: Heart Mediastinum ratio (H/Mlate), Washout (WR). The SGLT2-I modulate/reduce dysfunction in T2DM VVS. This effect reduce VVS patients.In a prospective multicenter study, after propensity score matching, we studied population 324...
Abstract Objectives To evaluate clinical outcomes in patients with diabetes, treated by cardiac resynchronization therapy a defibrillator (CRT-d), and glucagon-like peptide 1 receptor agonists (GLP-1 RA) addition to conventional hypoglycemic vs. CRTd under drugs. Background Patients diabetes experienced an amelioration of functional New York Association Heart class, reduction hospital admissions, mortality, percentage about 60%. However, 40% experience worse prognosis. Materials methods We...
We evaluated whether Angiotensin receptor/Neprilysin inhibitors (ARNI) reduce heart failure (HF) hospitalizations and deaths in cardiac resynchronization therapy with defibrillator (CRTd) non-responders patients at 12 months of follow-up, modulating microRNAs (miRs) implied adverse remodeling.adverse remodeling characterized by left ventricle ejection fraction (LVEF) reduction, ventricular end-systolic volume (LVESv) increase, the 6-minute walking test (6MWT) reduction are relevant...
BACKGROUND: internal cardioverter defibrillator (ICD) therapy reduced all-cause mortality. Conversely, few studies reported that ICDs' shocks may reduce survival. Recently authors suggested that, multiple inflammatory and molecular pathways were related to worse prognosis in metabolic syndrome (MS) patients treated by ICDs. Therefore, it be relevant find new biomarkers predict shock patients. METHODS: 99 MS vs. 107 no ICD for primary prevention, we evaluated mortality, cardiac deaths,...
Metabolic syndrome (MS) is a multifactorial disease that can affect clinical outcomes in patients treated by Cardiac Resynchronization Therapy with defibrillator (CRT-d). Ninety-one received CRT-d. According to diagnosis, the study population was divided into 46 MS (cases) versus 45 no (controls) patients. These were followed clinical, instrumental assessment, and device telemetric interrogations at follow-up. The design of evaluate functionality CRT-d leads, arrhythmic events, response, At...
The longevity of defibrillators (ICD) is extremely important from both a clinical and economic perspective. We studied the reasons for device replacement, removed ICD, existence possible factors associated with shorter service life.Consecutive patients who underwent ICD replacement March 2013 to May 2015 in 36 Italian centers were included this analysis. Data on replaced devices collected. A total 953 In 813 (85%) reason was battery depletion, while 88 (9%) remaining 52 because system...
Abstract Background Type 2 diabetes mellitus (T2DM) is a multi factorial disease, affecting clinical outcomes in failing heart patients treated by cardiac resynchronization therapy with defibrillator (CRT-d). Methods One hundred and ninety-five T2DM received CRT-d treatment. Randomly the study population via multipolar left ventricle (LV) lead pacing (n 99, group), vs bipolar LV 96, group). These were followed clinical, instrumental assessment, telemetric device control at follow up. In this...
Objectives: To evaluate atrial fibrillation (AF) recurrence and Sarcoplasmic Endoplasmic Reticulum Calcium ATPase (SERCA) levels in patients treated by epicardial thoracoscopic ablation for persistent AF. Background: Reduced of SERCA have been reported the peripheral blood cells with We hypothesize that can predict response to ablation. Methods: designed a prospective, multicenter, observational study recruit, from October 2014 June 2016, AF receiving an pulmonary vein isolation. Results:...
Hepatitis B virus markers were tested in the serum of 49 children with acute leukemia on clinical presentation and during subsequent chemotherapy. surface antigenemia was observed only six patients (12%), none whom progressed to chronic infection. Chemotherapy had a marked suppressive effect production antibodies hepatitis antigens overt infection occurred two after suppression protective immunity. Evidence liver damage frequently largely independent serologic data. These results indicate...
Introduction: Conduction disturbances and arrhythmias characterize the cardiac feature of myotonic dystrophy type 1 (MD1); a myocardial involvement has been suggested as part disease. The aim our study was to investigate underlying alterations using electroanatomic mapping (CARTO) their possible correlation with genetic neurological findings. Methods Results: Right atrial ventricular CARTO maps were obtained in 13 MD1 patients. Thirteen age‐matched patients paroxysmal supraventricular...
The Really ProMRI study evaluates magnetic resonance imaging (MRI) access for patients with cardiac implantable electronic devices (CIEDs) as well the performance of (MR)-conditional leads when undergoing MRI. Patients either an MR-conditional pacemaker or defibrillator (ICD) system at least a component (device one more leads) from system, were asked to fill in questionnaire they referred MR scan. rate prescription, denial, execution examinations was evaluated 1-year follow-up visit. In...
Endothelial dysfunction (ED) causes worse prognoses in heart failure (HF) patients treated with cardiac resynchronization therapy (CRTd). ED triggers the downregulation of microRNA-130 (miR-130a-5p), which targets endothelin-1 (ET-1). Thus, we evaluated and response to CRTd by assessing miR-130a-5p ET-1 serum levels. We designed a prospective multi-center study 1-year follow-up evaluate ED, ET-1, (ED-CRTd) vs. without (NED-CRTd). Clinical outcomes were response, HF hospitalization, death,...