A5101993444- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Geotechnical Engineering and Underground Structures
- Dental Trauma and Treatments
- Antimicrobial Resistance in Staphylococcus
- Dental Implant Techniques and Outcomes
- Pneumocystis jirovecii pneumonia detection and treatment
- dental development and anomalies
- Structural Load-Bearing Analysis
- Scientific and Engineering Research Topics
- Skin and Cellular Biology Research
- Protease and Inhibitor Mechanisms
- Bacteriophages and microbial interactions
- Laser Applications in Dentistry and Medicine
- Electrocatalysts for Energy Conversion
- Geotechnical Engineering and Soil Stabilization
- Wnt/β-catenin signaling in development and cancer
- Streptococcal Infections and Treatments
- MicroRNA in disease regulation
- Electrochemical Analysis and Applications
- Surfactants and Colloidal Systems
- Dental Anxiety and Anesthesia Techniques
- Diet, Metabolism, and Disease
- Nail Diseases and Treatments
- Innovative concrete reinforcement materials
PowerChina (China)
2022
Wenzhou Medical University
2016-2021
Wenzhou University
2021
Sichuan University
2010-2012
Abbott Fund
2000-2004
Abbott (United States)
2002
A novel series of erythromycin derivatives has been discovered with potent activity against key respiratory pathogens, including those resistant to erythromycin. These compounds are characterized by having an aryl group tethered the C-6 position erythronolide skeleton. Extensive structural modification moiety led discovery several promising both mef- and erm-mediated Streptoccoccus pneumoniae. Preliminary mechanistic studies indicated that new macrolides protein synthesis inhibitors, which...
Background: This study was aimed to prepare a novel magnetic thermosensitive cationic liposome drug carrier for the codelivery of Oxaliplatin (OXA) and antisense lncRNA MDC1 (MDC1-AS) Cervical cancer cells evaluate efficiency this its antitumor effects on cancer. Methods: Thermosensitive liposomes were prepared using thin-film hydration method. The OXA MDC1-AS vectors loaded into system, in vitro release activity, regulating MDC1, cytotoxicity, vivo activity determined. Results: system had...
ABSTRACT Macrolide resistance in Streptococcus pneumoniae has been associated with two main mechanisms: target modification by Erm methyltransferases and efflux macrolide pumps. The ketolide ABT-773, which a 3-keto group no l -cladinose sugar, represents new class of drugs vitro activity against variety resistant bacteria. Several approaches were undertaken to understand how ABT-773 was able defeat mechanisms. We demonstrated tighter ribosome binding than erythromycin. also showed that (i)...
ABSTRACT The activity of a new ketolide, ABT-773, was compared to the ketolide telithromycin (HMR-3647) against over 600 gram-positive clinical isolates, including 356 Streptococcus pneumoniae , 167 Staphylococcus aureus and 136 pyogenes isolates. Macrolide-susceptible isolates as well macrolide-resistant with ribosomal methylase (Erm), macrolide efflux (Mef), mutations were tested using NCCLS reference broth microdilution method. Both compounds extremely active macrolide-susceptible minimum...
One major mechanism for resistance to macrolide antibiotics in Streptococcus pneumoniae is MLS (macrolide, lincosamide, and streptogramin B) resistance, manifested when the 23S rRNA methylated by product of an erm gene. This modification results decreased binding all known macrolide, B ribosome. More than 30 ermAM-containing clinical isolates S. were examined our lab showed high-level (MIC ≥ 128 μg/ml) erythromycin, azithromycin, tylosin, clindamycin, ketolide (macrolides that lack cladinose...
ABSTRACT We report the discovery and characterization of a novel ribosome inhibitor (NRI) class that exhibits selective broad-spectrum antibacterial activity. Compounds in this inhibit growth many gram-positive gram-negative bacteria, including common respiratory pathogens Streptococcus pneumoniae , Haemophilus influenzae Staphylococcus aureus Moraxella catarrhalis are nontoxic to human cell lines. The first NRI was discovered high-throughput screen designed identify inhibitors cell-free...
The authors report the development of a high-throughput screen for inhibitors Streptococcus pneumoniae transcription and translation (TT) using luciferase reporter, secondary assays used to determine biochemical spectrum activity bacterial specificity. More than 220,000 compounds were screened in mixtures 10 per well, with 10,000 picks selected further study. False-positive hits from inhibition an extremely common artifact. After filtering several known classes antibiotics, approximately 50...
Phosphorus incorporation further boosted the OER activity of cation-doped Co-based spinel oxides <italic>via</italic> remarkably tuning oxygen vacancies, crystallinity and electrochemically active surface area on surface.
NudC domain containing 1 (NUDCD1) is an oncoprotein frequently activated or upregulated in various human cancers, but its role pancreatic cancer (PC) remains unknown. Thus, we aimed to determine the function and mechanism of NUDCD1 PC. We employed Western blot quantitative real-time polymerase chain reaction assess expression cells PC tissues. was knocked down Patu8988 PANC-1 cells. conducted cell analysis, wound healing assay, transwell assay colony formation evaluate metastatic...
Nicotine, the main psychoactive component of tobacco, affects cell metabolism, proliferation, adhesion and, importantly, osteogenic differentiation fibroblasts. Approximately 15% all orthodontic patients are adults among who one-fifth smokers. Hence, it is necessary to have insight into effects nicotine on hPDLCs during tooth movement. This study aimed investigate and mechanisms human periodontal ligament cells (hPDLCs) under application cyclic tensile stress.hPDLCs were obtained from donor...
For the Honghe Bridge project located in Yunnan Province, Southwest China, a steel/ultrahigh-performance concrete (UHPC) composite deck is used suspension bridge with 700 m main span, and steel stud connectors are 50 mm-thick UHPC layer. To investigate shrinkage behavior of relevant influence, situ time-dependent strain measured continuously, within 20-day curing time, material summarized based on test results. This paper proposes prediction model for which refined from widely B3 normal...
Pile composite foundation (PCF) supporting anchorage foundations and immersed tube is subjected to significant vertical lateral loads, where the PCF design often controlled by displacement of head. Therefore, behavior loaded an important issue concerned engineers, but no published guidance can be referred. An semi-analytical method adopted predict behaviors, reduction factor t-th row fp(t) group efficiency fg are induced account for effects. The system decomposed into fictitious piles...
Mechanical strain plays an important role in bone formation and resorption during orthodontic tooth movement. The mechanism has not been fully studied, the process becomes complex with increased amounts of periodontal patients seeking care. Our aims were to elucidate combined effects proinflammatory cytokines intermittent cyclic (ICS) on osteogenic capacity human ligament cells. Cultured cells exposed (interleukin-1β 5 ng/mL tumor necrosis factor-α 10 ng/mL) for 1 days, ICS (0.5 Hz, 12%...
Seismic investigation revealed that a fault fracture zone is one of the most vulnerable areas mountain tunnels in earthquakes. For tunnel crossing secondary fault, may be permanently dislocated by causative faults during earthquakes, making subject to combined action seismic motion and dislocation, which makes response more complicated. In order investigate fault-crossing this case explore suitability different aseismic measures, three-dimensional numerical models with widths measures were...