A5047422029- FOXO transcription factor regulation
- Cell death mechanisms and regulation
- PARP inhibition in cancer therapy
- Cancer-related Molecular Pathways
- Mitochondrial Function and Pathology
- Phytoestrogen effects and research
- Metabolism, Diabetes, and Cancer
- Food and Agricultural Sciences
- Food composition and properties
- GABA and Rice Research
- Child Nutrition and Water Access
- DNA Repair Mechanisms
- Thyroid Disorders and Treatments
- Seed and Plant Biochemistry
Nepal Agricultural Research Council
2022-2025
University of Cincinnati Medical Center
2025
Dongguk University
2021-2024
Kathmandu University
2015
Considerable emphasis is being placed on combinatorial chemotherapeutic/natural treatments for breast cancer. This study reveals the synergistic anti-tumor activity of morin and Doxorubicin (Dox) co-treatment MDA-MB-231 triple-negative cancer (TNBC) cell proliferation. Morin/Dox treatment promoted Dox uptake induced DNA damage formation nuclear foci p-H2A.X. Furthermore, repair proteins, RAD51 survivin, cycle cyclin B1 forkhead Box M1 (FOXM1), were by alone but attenuated morin/Dox...
The germination of millets is a traditional yet underutilized method to enhance their nutritional and functional attributes. This study investigates the impact time on bioactive, enzymatic, antinutritional properties proso millet (Chino Dude) foxtail (Kaguno Red Kaguno White) varieties. Germination was conducted over five days (0-5 days), changes in total phenolic flavonoid content, tannin antioxidant activity, diastatic power, α-amylase reducing sugars, trypsin inhibition activity were...
Abstract HER2 amplification or mutation accounts for 25% of breast cancer patients that can advance to metastatic disease. Therefore, it is important identify novel genes which mediate metastasis in HER2+ cancer. Here, we describe a new suppressor gene, Class II phosphatidylinositol 3-kinases (Pik3c2b), by vivo CRISPR-Cas9 library screening custom designed targeting implicated autophagy using murine (N418) cells. We further showed PI3KC2β KO N418 cells increased their migration and invasion...
Abstract Breast cancer chemoresistance hampers chemotherapy efficacy; researchers investigate the pharmacological activities of natural products for potential solutions. This study aimed to determine effect morin, a bioflavonoid isolated from Maclura pomifera , on two Dox‐resistant human breast cell lines MDA‐MB‐231 (MDA‐DR) and MCF‐7 (MCF‐DR). Sulforhodamine B colony‐forming assays demonstrated cytotoxic morin both lines. Morin induced DNA damage reduced repair mechanism, feature...
Background:The diverse role of pharmacist for management chronic disease carries significant effects.Hypothyroidism, common endocrine disorders can affect multiple organs.So, educating patient bring fluorescent in like hypothyroidism.This study assessed the provided intervention hypothyroid patients terms knowledge, attitude and practice outcomes.Method: A prospective, case controlled, interventional based with total 118 diagnosed condition as inclusion criteria.Knowledge, regarding...
Four formulations of cereal bar were prepared using common buckwheat (55 parts), proso millet (15-30 white amaranth (25-40 walnut (27.5 and jaggery (50 by varying the proportions in ratio 15:40, 20:35, 25:30 30:25. Roasted cereals pieces mixed with syrup 73.7° Bx baked at 120° C for 20 minutes. The bars' proximate composition, mineral content (Ca, Fe P) evaluated compared available market. textural analysis sensory profile also evaluated. crude fiber, calcium, iron significantly higher...
Micronutrient deficiencies are a significant global health concern, especially in developing countries like Nepal. This review explores the effectiveness, challenges, and strategies of food fortification combating these deficiencies. Drawing from diverse sources, including government reports, academic literature, international organizations, we analyze types fortification, their implementation, impact on public health. highlights improvements outcomes through initiatives, such as 32%...