A5077140024- Plant Pathogens and Resistance
- Autopsy Techniques and Outcomes
- Agriculture, Plant Science, Crop Management
- Plant Disease Resistance and Genetics
- Plant-Microbe Interactions and Immunity
- Cancer Genomics and Diagnostics
- Prenatal Screening and Diagnostics
- Acute Myeloid Leukemia Research
- Cancer-related Molecular Pathways
- Acute Lymphoblastic Leukemia research
- Legume Nitrogen Fixing Symbiosis
- Plant Parasitism and Resistance
- Genomics and Phylogenetic Studies
- DNA Repair Mechanisms
- Botanical Research and Chemistry
- Adrenal and Paraganglionic Tumors
- Photosynthetic Processes and Mechanisms
- Plant nutrient uptake and metabolism
- Neuroblastoma Research and Treatments
- Genomics and Chromatin Dynamics
- Plant Molecular Biology Research
- Ethics and Legal Issues in Pediatric Healthcare
- Plant pathogens and resistance mechanisms
- Genetic factors in colorectal cancer
- Molecular Biology Techniques and Applications
University of Oulu
2018-2024
Centre for Cancer Biology
2019-2023
University of South Australia
2019-2023
South Australia Pathology
2019-2023
MRC Weatherall Institute of Molecular Medicine
2019
University of Oxford
2019
NordLab
2018
The University of Western Australia
2005-2016
Australian Research Council
2016
Murdoch University
2011-2015
This paper describes the effect of phosphite (Phi), a systemic chemical, on induction defence responses in Phytophthora cinnamomi ‐infected Arabidopsis thaliana accessions Ler and Col‐0. Application Phi to non‐inoculated A . seedlings accession elevated transcription genes salicylic acid ( PR1 PR5 ) jasmonic acid/ethylene THI2.1 PDF1.2 pathways. Furthermore, increase expression gene was demonstrated Phi‐treated using transgenic line :: GUS presence/absence pathogen by 72 h after inoculation....
Abstract Pregnancy loss and perinatal death are devastating events for families. We assessed ‘genomic autopsy’ as an adjunct to standard autopsy 200 families who had experienced fetal or newborn death, providing a definitive candidate genetic diagnosis in 105 Our cohort provides evidence of severe atypical utero presentations known disorders identifies novel phenotypes disease genes. Inheritance 42% diagnoses were either autosomal recessive (30.8%), X-linked (3.8%) dominant (excluding de...
Phytophthora cinnamomi is a devastating pathogen worldwide and phosphite (Phi), an analogue of phosphate (Pi) highly effective in the control this pathogen. Phi also interferes with Pi starvation responses (PSR), which auxin signalling integral component. In current study, involvement pathways host Phi-mediated resistance to P. was investigated by screening Arabidopsis thaliana ecotype Col-0 several mutants defective PSR response pathway for their susceptibility The treatment studied...
We report the partial complementation and subsequent comparative molecular analysis of two nonviable mutants impaired in chloroplast translation, one (emb2394) lacking RPL6 protein, other (emb2654) carrying a mutation gene encoding P-class pentatricopeptide repeat protein. show that EMB2654 is required for trans-splicing plastid rps12 transcript therefore emb2654 mutant lacks Rps12 protein fails to assemble small subunit ribosome, explaining loss translation consequent embryo-lethal...
Strong inherited predisposition to breast cancer is estimated cause about 5-10% of all cases. As the known susceptibility genes, such as BRCA1 and BRCA2, explain only a fraction this, additional predisposing genes related biological mechanisms are actively being searched for. We have recently identified recurrent MCPH1 germline mutation, p.Arg304ValfsTer3, allele. encodes multifunctional protein involved in maintenance genomic integrity it also somatically altered various types, including...
Abstract Heterozygous mutations in any of three major genes, BRCA1 , BRCA2 and PALB2 are associated with high-risk hereditary breast cancer susceptibility frequently seen as familial disease clustering. is a key interaction partner regulator several vital cellular activities BRCA2, thus required for DNA damage repair alleviation replicative oxidative stress. Little however known about how PALB2-deficiency affects cell function beyond that, especially the three-dimensional setting, also its...
Brassica juncea (L.) Czern & Coss (mustard) has potential as a more drought-tolerant oilseed crop than the napus, and first two canola-quality B. cultivars will be sown large strip trials across Australia in 2005. This allow commercial evaluation of oil meal quality for seed multiplication release Australia-wide 2006. Inspection experimental field plantings at Beverley (32°6′30″S, 116°55′22″E), Wongan Hills (30°50′32″S, 116°43′33″E), Western September 2004 indicated occurrence extensive...
Bradyrhizobium sp. strain WSM1743 is an aerobic, motile, Gram-negative, non-spore-forming rod that can exist as a soil saprophyte or legume microsymbiont of Indigofera was isolated from nodule recovered the roots growing 20 km north Carnarvon in Australia. It slow growing, tolerates up to 1 % NaCl and capable growth at 37 °C. Here we describe features WSM1743, together with genome sequence information its annotation. The 8,341,956 bp high-quality permanent draft arranged into 163 scaffolds...
Abstract Whilst heterozygous germline mutations in the ABRAXAS gene have been associated with hereditary breast cancer predisposition, their initial effect on promoting tumorigenesis at cellular level has not explored. Here, we demonstrate patient-derived cells that Finnish founder mutation (c.1082G>A, Arg361Gln), even state leads to decreased BRCA1 protein levels as well reduced nuclear localization and foci formation of CtIP. This causes disturbances basal BRCA1-A complex...