A5001758021- Pituitary Gland Disorders and Treatments
- Bone health and osteoporosis research
- Neuroendocrine Tumor Research Advances
- Adrenal and Paraganglionic Tumors
- Diabetes Treatment and Management
- Renal Transplantation Outcomes and Treatments
- Cancer, Hypoxia, and Metabolism
- Gestational Diabetes Research and Management
- Hip and Femur Fractures
- Neuroblastoma Research and Treatments
- Bone health and treatments
- Diabetes Management and Research
- Diabetes and associated disorders
- Parathyroid Disorders and Treatments
- Bone fractures and treatments
- Metabolism, Diabetes, and Cancer
- Glioma Diagnosis and Treatment
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Forensic Toxicology and Drug Analysis
- Pancreatic function and diabetes
- Air Quality and Health Impacts
- Renal and related cancers
- Clinical Reasoning and Diagnostic Skills
- Prenatal Substance Exposure Effects
The Royal Melbourne Hospital
2015-2025
The University of Melbourne
2015-2025
Western Health
2011-2025
Hospital Universitario Son Espases
2018-2025
Melbourne Health
2014-2025
Churchill Hospital
2014-2022
Oxford Centre for Diabetes, Endocrinology and Metabolism
2014-2022
University of Oxford
2014-2022
Queen Margaret University
2015
University of Cape Town
2013-2014
This study hypothesized that 3,4-methylenedioxymetamfetamine intoxication presents with distinct clinical features and outcomes when combined other substances of misuse, compared to mono-3,4-methylenedioxymetamfetamine intoxication. investigated the presentation acute intoxication, exclusive co-usage ethanol, 3,4-methylenedioxymetamfetamine-co-intoxication or without a focus on patient sex differences. A retrospective analysis was conducted using Euro-DEN Plus database (2013-2022), which...
OBJECTIVE To determine the microbiological profile of diabetes-related foot infections (DRFIs) and impact wound duration, inpatient treatment, chronic kidney disease (CKD). RESEARCH DESIGN AND METHODS Postdebridement samples were collected from individuals presenting with DRFIs 1 January 2005 to 31 December 2007. RESULTS A total 653 specimens 379 36% identifying only one isolate. Of isolates, 77% gram-positive bacteria (staphylococci 43%, streptococci 13%). Methicillin-resistant...
Eight patients with Raynaud9s syndrome were treated by weekly plasma exchange for four weeks using a Haemonetics Model 30 Blood Processor. The mean whole-blood viscosity at shear rate of 0.77/s was significantly lower after treatment, and the index red-cell deformability improved. In studied serially percentage fall in single 49% but only 14% 91/s. All noticed symptomatic improvement including healing ischaemic digital ulcers. six number arterial segments containing detectable blood flow...
The sensitivity of fasting plasma glucose (FPG) in screening for new-onset diabetes after transplantation (NODAT) has been questioned, particularly the presence moderate-dose prednisolone, where peak occurs 7 to 8 hr administration. Oral tolerance testing (OGTT) mooted as an alternative but is inconvenient patients.We compared tests NODAT at 6 weeks, 3 months, and 12 months kidney recipients receiving mycophenolate, tacrolimus.At (capillary blood [CapBG] ≥11.1 mmol/L, FPG ≥7.0 2-hr or...
Inhibin and activin are structurally related dimeric peptide hormones members of the TGF-beta superfamily proteins. In accompanying paper, we describe transgenic mice that overexpress inhibin alpha-subunit gene from a metallothionein-I promoter (MT-alpha) examine effects MT-alpha transgene on gonadotropin levels fertility. To characterize increased gonadal morphology function, in this report investigate histology, steroid hormone levels, basis ovarian cyst formation mice. female develop...
BACKGROUND--Evidence from laboratory studies suggests that air pollution can produce bronchoconstriction and respiratory symptoms in selected subjects, but the relevance of these findings to exposure natural is unclear. This study was performed determine whether at typical levels found UK has demonstrable effects on function subjects with airways disease. METHODS--Seventy five adult patients diagnoses asthma or chronic obstructive pulmonary disease (COPD) were studied for a period four weeks...
Abstract This case describes a man with an unusual cause of atypical subtrochanteric fracture, pycnodysostosis. condition results from mutations involving the cathepsin K gene. New antiresorptive treatments for osteoporosis inhibit enzyme in osteoclasts. Therefore, there should be vigilant monitoring development long-term complications noted to occur diseases reduced osteoclast function, including pycnodysostosis, patients receiving these novel agents. © 2011 American Society Bone and...
Prednisolone is a major risk factor for hyperglycaemia and new-onset diabetes after transplantation. Uncontrolled observational data suggest that divided dosing may reduce requirements hypoglycaemic agents. This study aims to compare the glycaemic effects of twice daily (BD) once (QD) prednisolone. Twenty-two kidney transplant recipients without were randomized BD or QD Three weeks post-transplant, continuous glucose monitor (iPro2® Medtronic) was applied 5 days with subjects continuing...
Inhibin is an important modulator of reproductive function at both the endocrine level, through its regulation pituitary FSH biosynthesis, and paracrine autocrine levels, as intragonadal regulatory factor. To investigate in vivo actions inhibin gonadal function, transgenic mice that overexpress rat α-subunit gene were generated. A transgene includes mouse metallothionein-I promoter (MT-α) fused to precursor coding sequences was used produce three lines mice. Transgene mRNA expressed numerous...
Abstract Purpose Germline succinate dehydrogenase (SDHx) mutation carriers, especially SDHB, are at increased risk for malignancy and require life-long surveillance. Current guidelines recommend periodic whole-body MRI imaging. We assessed the incremental value of 68Ga-DOTA-octreotate (GaTate) positron emission tomography (PET)/CT compared with conventional imaging in such patients. Methods SDHx carriers who had GaTate PET/CT were retrospectively reviewed. Detection lesions or CT on a...
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by occurrence of parathyroid tumours and neuroendocrine (NETs) the pancreatic islets anterior pituitary. The MEN1 gene, encoding menin, a tumour suppressor, but its precise role in initiating vivo tumourigenesis remains to be elucidated. availability temporally controlled conditional mouse model would greatly facilitate study such early tumourigenic events, overcome limitations other knockout models,...
Background The lack of osteoporosis treatment initiation after fragility fractures is a significant gap, especially in primary care. It unclear whether barriers for care physicians (PCPs) arise from uncertainty about investigations, initiation, or medication side effects. Key questions remain active learning platforms improve rates better than passive methods and how PCP demographics affect outcomes. With PCPs increasingly using web-based continuing professional development due to time...
ABSTRACT Background In patients with diabetes, antenatal glucocorticoids can induce transient maternal hyperglycaemia for approximately 72 h. This may be associated adverse outcomes, including neonatal hypoglycaemia, prompting recommendations prophylactic increases in insulin by some expert groups; however, there are no validated protocols. A review of our institutional practice empiric dose escalation (Day 1:25%, Day 2–3:40%, 4:20%, 5:10%) determined it was inadequate to prevent...
Pooled perturbation screens can reveal cellular regulatory networks, yet scaling these techniques for large-scale in animals remains challenging. To address this, we developed MIC-Drop-seq, which combines high-throughput CRISPR gene disruption zebrafish embryos with phenotyping by multiplexed single-cell RNAseq. In one MIC-Drop-seq experiment, simultaneously identified changes expression and cell abundance across 74 types resulting from loss of function 50 transcription factors. These...
<sec> <title>BACKGROUND</title> Osteoporosis poses a significant global health burden and is responsible for over 8.9 fragility fractures annually. Despite evidence-based guidelines treatment, substantial care gap persists, with only low percentage of fracture patients receiving guideline-concordant care. Primary physicians (PCPs) are pivotal in community-based prevention but face challenges translating knowledge into practice. While hospital-based liaison services (FLS) effective, their...
Background Health care practitioners (HPs), in particular general (GPs), are increasingly adopting Web-based social media platforms for continuing professional development (CPD). As GPs restricted by time, distance, and demanding workloads, a health virtual community of practice (HVCoP) is an ideal solution to replace face-to-face CPD with CPD. However, barriers such as time work schedules may limit participation HVCoP. Furthermore, it difficult gauge whether engage actively or passively...
Laboratory-based studies have shown that ozone and nitrogen dioxide can potentiate the effect of allergen in sensitized asthmatic subjects, but it is not known whether this interaction important under natural exposure conditions. Thirty-five subjects with clinical diagnoses asthma or chronic obstructive pulmonary disease a provocative dose causing 20% fall forced expiratory volume one second methacholine <12.25 micromol (using Yan method) kept peak flow (PEF) records for 4-week period during...