A5077252865- Laser-Matter Interactions and Applications
- Laser-Plasma Interactions and Diagnostics
- Laser Design and Applications
- Solid State Laser Technologies
- Receptor Mechanisms and Signaling
- Complementary and Alternative Medicine Studies
- Alzheimer's disease research and treatments
- Ion channel regulation and function
- Drug-Induced Hepatotoxicity and Protection
- Laser-induced spectroscopy and plasma
- Advanced Fiber Laser Technologies
- Antimicrobial Peptides and Activities
- Nephrotoxicity and Medicinal Plants
- Ethnobotanical and Medicinal Plants Studies
- Neuroscience and Neuropharmacology Research
- Nicotinic Acetylcholine Receptors Study
- Photorefractive and Nonlinear Optics
- Neuropeptides and Animal Physiology
- Laser Material Processing Techniques
- High-pressure geophysics and materials
- Venomous Animal Envenomation and Studies
- Ginkgo biloba and Cashew Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurobiology and Insect Physiology Research
- Poisoning and overdose treatments
The University of Adelaide
2015-2025
Rutherford Appleton Laboratory
2012-2023
Science and Technology Facilities Council
2010-2023
Central Laser Facility
2019-2022
Research Complex at Harwell
2022
Laser 2000 (United Kingdom)
2019
University of Lisbon
2019
St. Thomas Hospital
2017
Faculty of Public Health
2016
Australian National University
2014
The Vulcan Nd : glass laser at the Central Laser Facility is a Petawatt (1015 W) interaction facility available to UK and international user community. came online users in 2002 considerable experience has been gained operating this mode. designed deliver irradiance on target of 1021 W cm−2 for wide-ranging experimental programme fundamental physics advanced applications. This includes super-high-intensity light with matter, fast ignition fusion research, photon induced nuclear reactions,...
Abstract Globally, there has been an increase in the use of herbal remedies including traditional Chinese medicine (TCM). There is a perception that products are natural, safe and effectively regulated, however, regulatory agencies hampered by lack toolkit to audit ingredient lists, adulterants constituent active compounds. Here, for first time, multidisciplinary approach assessing molecular content 26 TCMs described. Next generation DNA sequencing combined with toxicological heavy metal...
The aim of this project is to establish a 10 PW facility on the Vulcan laser system capable being focussed intensities at least 1023 Wcm−2 and integrate into flexible unique user This paper will present progress made in Phase one developing 10PW Front End as well concept for new facility. be configured way maximise scientific opportunities presented through combination with existing capabilities already established Vulcan. ground breaking development open up range opportunities.
Selenite is an inorganic form of selenium that has a cytotoxic effect against several human cancer cell lines: one or more selenite metabolites are considered to be responsible for its toxicity. X-ray absorption spectroscopy was used monitor Se speciation in A549 lung cells incubated with over 72 h. As anticipated, selenodiglutathione and elemental both comprised large proportion the between 4 h after treatment, which accordance reductive metabolism presence glutathione reductase/NADPH...
An all-optical approach to laser-proton acceleration enhancement is investigated using the simplest of target designs demonstrate application-relevant levels energy conversion efficiency between laser and protons. Controlled deposition energy, in form a double-pulse temporal envelope, combination with thin foil targets which recirculation laser-accelerated electrons can lead optimal conditions for coupling drive into proton beam. This shown deliver substantial 5–30 MeV protons, compared...
Amyloid fibril formation is associated with diseases such as Alzheimer's, Parkinson's, and prion diseases. Inhibition of amyloid by molecular chaperone proteins, the small heat-shock protein αB-crystallin, may play a protective role in preventing toxicity this form misfolding. Reduced carboxymethylated κ-casein (RCMκ-CN), derived from milk, readily reproducibly forms fibrils at physiological temperature pH. We investigated RCMκ-CN using neuronal model PC12 cells determined whether inhibition...
Oxygen homeostasis is essential for the development and normal physiology of an organism. Hypoxia causes mitochondrial electron transport chain to generate higher levels reactive oxygen species resulting in oxidative stress. can be a d
Ion acceleration driven by the interaction of an ultraintense (2 × 1020 W cm−2) laser pulse with ultrathin ( nm) foil target is experimentally and numerically investigated. Protons accelerated sheath fields via radiation pressure are angularly separated identified based on their directionality signature features (e.g. transverse instabilities) in measured spatial-intensity distribution. A low divergence, high energy proton component also detected when heated electrons expand becomes...
Giant electromagnetic pulses (EMP) generated during the interaction of high-power lasers with solid targets can seriously degrade electrical measurements and equipment. EMP emission is caused by acceleration hot electrons inside target, which produce radiation across a wide band from DC to terahertz frequencies. Improved understanding control vital as we enter new era high repetition rate, intensity (e.g. Extreme Light Infrastructure). We present recent data VULCAN laser facility that...
The Vulcan Nd:glass laser at the Central Laser Facility (CLF) is a petawatt (1015 Watts) interaction facility, designed to deliver irradiance on target of 1021W.cm−2 for UK and international user community. facility came online users in 2002 considerable experience has been gained operating this mode. delivers wide-ranging experimental program fundamental physics advanced applications. This includes ultrahigh intensity light with matter, fast ignition fusion research, photon induced nuclear...
Selenium compounds exhibit chemopreventative properties at supranutritional doses, but the efficacy of selenium supplementation in cancer prevention is dependent on chemical speciation supplement and its metabolites. The uptake, speciation, distribution common selenoamino acid supplements, selenomethionine (SeMet) Se-methylselenocysteine (MeSeCys), A549 human lung cells were investigated using X-ray absorption fluorescence spectroscopies. spectroscopy bulk cell pellets treated with acids for...
Abstract The amphibian skin is a vast resource for bioactive peptides, which form the basis of animals' innate immune system. Key components secretions cutaneous glands are antimicrobial peptides (AMPs), exert their cytotoxic effects often as result membrane disruption. It becoming increasingly evident that there link between mechanism action AMPs and amyloidogenic proteins. In this work, we demonstrate broad‐spectrum AMP uperin 3.5, has random‐coil structure in solution but adopts an...
This paper describes the first experimental demonstration of guiding a relativistic electron beam in solid target using two co-linear, relativistically intense, picosecond laser pulses. The pulse creates magnetic field which guides higher current fast generated by second pulse. effects intensity ratio, delay, total energy and intrinsic pre-pulse are examined. Thermal K{\alpha} imaging showed reduced emission size, increased peak at delays 4 - 6 ps, an ratio 10 : 1 (second:first) 186 J. In...