A5065233408- Cannabis and Cannabinoid Research
- Alzheimer's disease research and treatments
- Gastrointestinal motility and disorders
- Seaweed-derived Bioactive Compounds
- GABA and Rice Research
- Neuroscience and Neuropharmacology Research
- Gastroesophageal reflux and treatments
- Neuropeptides and Animal Physiology
- Cholinesterase and Neurodegenerative Diseases
- Biochemical Analysis and Sensing Techniques
- Ginkgo biloba and Cashew Applications
- Parkinson's Disease Mechanisms and Treatments
- Ion Channels and Receptors
- Protein Hydrolysis and Bioactive Peptides
- Helicobacter pylori-related gastroenterology studies
- Tea Polyphenols and Effects
- Neuroscience of respiration and sleep
- Phytochemicals and Antioxidant Activities
- Oral health in cancer treatment
- Biochemical effects in animals
- Sleep and Wakefulness Research
- Tryptophan and brain disorders
- Esophageal and GI Pathology
- Bioactive Compounds in Plants
- Eosinophilic Esophagitis
The University of Adelaide
2016-2025
Faculty of Public Health
2016-2020
Bond University
2006
Royal Adelaide Hospital
2000-2002
Hanson Institute
2000-2001
With the global increase in hyperglycemia and hyperlipidemia, there is an urgent need to explore dietary interventions targeting inhibition of dipeptidyl peptidase-IV (DPP-IV) lipid digestion absorption. This study investigated how Lactobacillus rhamnosus GG (LGG) affects various aspects black goji berry (BGB) (Lycium ruthenicum Murr.) juice, including changes physicochemical functional properties, as well microbiological sensory attributes. Throughout fermentation process with 2.5–10% (w/v)...
Plant polyphenols such as the lignin honokiol pictured are able to bind specific regions in amyloid β oligomer and this may be associated with neuroprotective effects neuronal cells.
The effects of cannabinoid subtype 1 (CB ) receptor activation were determined on smooth muscle, inhibitory and excitatory motorneuronal function in strips human colonic longitudinal muscle (LM) circular (CM) vitro . Electrical field stimulation (EFS; 0.5–20 Hz, 50 V) evoked a relaxation LM CM precontracted with neurokinin‐2 (NK‐2) selective agonist ( β ‐ala 8 ‐neurokinin A; 10 −6 M the presence atropine (10 ); this was unaltered following pretreatment CB ‐receptor...
GABA B -receptor (GABA R) agonists reduce transient lower esophageal sphincter relaxation (TLESR) and reflux episodes through an action on vagal pathways. In this study, we determined whether R are expressed afferent neurones they modulate distension-evoked discharge of afferents in the isolated stomach. Vagal mehanoreceptor activity was recorded following distensions ferret proximal stomach before after perfusion with R-selective baclofen 3-aminopropylphosphinic acid (3-APPiA). Retrograde...
White tea (WT) is one of six types originally derived from Fujian Province, China. known for its health-promoting properties. However, the neuroprotective and anti-aggregatory properties WT against hallmark toxic Alzheimer’s protein, Aβ have not been investigated. In this study, WT, green (GT), oolong (OT) black (BT) were manufactured using leaves cultivar Camellia sinensis (Jin Guanyin). The protective effects these extracts then studied under oxidative stress conditions via t-bhp H2O2...
Introduction Many chemotherapy agents used to treat advanced cancer are inherently mucotoxic, causing breakdown of the gastrointestinal mucosa (gastrointestinal mucositis (GI-M)) and lead a constellation secondary complications including diarrhoea, malnutrition, anorexia, pain, fatigue sleep disturbances. These symptoms usually managed individually, leading polypharmacy its associated risks. The endocannabinoid system regulates numerous biological behavioural processes with side effects,...
Aggregation of α-Synuclein (αS) protein to amyloid fibrils is a neuropathological hallmark Parkinson's disease (PD). Growing evidence suggests that extracellular αS aggregation plays pivotal role in neurodegeneration found PD addition the intracellular aggregates Lewy bodies (LB). Here, we identified and compared diverse set molecules capable mitigating exogenous toxicity αSA53T, more aggregation-prone mutant familial PD. For first time, investigated anti-amyloid activity semi-synthetic...
The impact of extract composition on the neuroprotective activities Ecklonia radiata was investigated in multiple assays vitro. A total six fractions (crude (CE), phlorotannin (PT), polysaccharide (PS), free sugar (FS), low molecular weight (LM), and high (HM)) prepared from E. were used to determine their effects against Aβ1-42 oxidative stress neuronal cell line PC-12. Only three (CE, PS, HM) demonstrated cytotoxicity at least highest concentration (100 μg/mL) tested PC-12 cells. All...