A5078540831- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Nuclear Structure and Function
- Bone and Joint Diseases
- Membrane Separation Technologies
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Cerebrovascular and Carotid Artery Diseases
- Muscle Physiology and Disorders
- Blood groups and transfusion
- Eicosanoids and Hypertension Pharmacology
- Genital Health and Disease
- Nitric Oxide and Endothelin Effects
- Cerebral Palsy and Movement Disorders
- Atomic and Subatomic Physics Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Acute Ischemic Stroke Management
- Cardiovascular Function and Risk Factors
- Dialysis and Renal Disease Management
- Vascular Malformations and Hemangiomas
- Neurogenetic and Muscular Disorders Research
- Sports injuries and prevention
- Hemoglobinopathies and Related Disorders
- Breast Lesions and Carcinomas
- Urologic and reproductive health conditions
Vanderbilt University Medical Center
2017-2021
Illinois College
2021
University of Illinois Urbana-Champaign
2021
Vanderbilt University
2011-2018
University of Alabama at Birmingham
2012
Muscle diseases commonly have clinical presentations of inflammation, fat infiltration, fibrosis, and atrophy. However, the results existing laboratory tests are not well correlated. Advanced quantitative MRI techniques may allow assessment myo-pathological changes in a sensitive objective manner. To progress towards this goal, an array protocols was implemented for human thigh muscles; their reproducibility assessed; statistical relationships among parameters were determined. These methods...
An implantable hemofilter for the treatment of kidney failure depends critically on transport characteristics membrane and biocompatibility membrane, cartridge, blood conduits. A novel with slit-shaped pores optimizes trade-off between permeability selectivity, enabling implanted therapy. Sustained (3–8) day function an parallel-plate minimal anticoagulation was achieved by considering at subnanometer scale chemical interactions millimeter fluid dynamics. total 400 nm-thick polysilicon flat...
A skeletal muscle's function is strongly influenced by the internal organization and geometric properties of its fibers, a property known as muscle architecture. Diffusion-tensor magnetic resonance imaging-based fiber tracking provides powerful tool for non-invasive architecture studies, has three-dimensional sensitivity, uses fixed frame reference. Significant advances have been made in technology, including defining seed points tracking, quantitatively characterizing architecture,...
The vertebrobasilar system (VBS) is unique in human anatomy that two arteries merge into a single vessel, and it especially important because supplies the posterior circulation of brain. Atherosclerosis develops this region, atherosclerotic plaques confluence can progress with catastrophic consequences, including artery occlusion. Quantitative assessments flow characteristics VBS could elucidate factors influence patterns confluence, deviations from normal might then be used to predict...
A major challenge in developing blood-contacting medical devices is mitigating thrombogenicity of an intravascular device. Thrombi may interfere with device function or embolize from the to occlude distant vascular beds catastrophic consequences. Chemical interactions between plasma proteins and bioengineered surface occur at nanometer scale; however, continuum models blood predict local shear stresses that lead platelet activation aggregation thrombosis. Here, iterative approach flow path...
Background and purpose Currently, there is neither a standard protocol for vessel wall MR imaging of intracranial atherosclerotic disease (ICAD) nor gold phantom to compare sequences. In this study, plaque developed characterized that provides platform establishing uniform approach ICAD. Materials methods A patient specific injection mold was 3D printed construct geometrically accurate ICAD phantom. Polyvinyl alcohol hydrogel infused into the core shell form stenotic artery. The incorporated...
Myeloperoxidase (MPO)-derived hypochlorous acid induces changes in HDL function via redox modifications at the level of apolipoprotein A-I (apoA-I). As 4F and apoA-I share structural functional properties, we tested hypothesis that acts as a reactive substrate for (HOCl). reduced HOCl-mediated oxidation fluorescent APF concentration-dependent manner (ED50∼ 56 ± 3 μM). This reaction induced physical properties 4F. Addition HOCl to molar ratios ranging from 1:1 3:1 band intensity on SDS-PAGE...
Purpose To assess the effect of anisotropic smoothing on fiber tracking measures, including pennation angle, tract length, and number in medial gastrocnemius (MG) muscle healthy subjects using diffusion-weighted magnetic resonance imaging (DW-MRI). Materials Methods 3T DW-MRI data were used for tractography MG subjects. Anisotropic was applied at three levels (5%, 10%, 15%), number, fractional anisotropy, principal eigenvector orientation quantified each level. Results Fiber length increased...
Quantitative magnetic resonance imaging (qMRI) describes the development and use of MRI to quantify physical, chemical, and/or biological properties living systems. Neuromuscular diseases often exhibit a temporally varying, spatially heterogeneous, multi-faceted pathology. The goal this protocol is characterize pathology using qMRI methods. acquisition begins with localizer images (used locate position body tissue interest within system), quality control measurements relevant field...
Studying the magnitude and kinetics of blood flow, oxygen extraction, consumption at exercise onset during recovery from can lead to insights into both normal control metabolism flow disturbances these processes in metabolic cardiovascular diseases. The purpose this study was examine on- off-kinetics for delivery, as functions submaximal contraction intensity. Eight healthy subjects performed four 1-min isometric dorsiflexion contractions, with two 20% MVC 40% MVC. During one each intensity,...
Quantitative magnetic resonance imaging (qMRI) describes the development and use of MRI to quantify physical, chemical, and/or biological properties living systems. Neuromuscular diseases often exhibit a temporally varying, spatially heterogeneous, multi-faceted pathology. The goal this protocol is characterize pathology using qMRI methods. acquisition begins with localizer images (used locate position body tissue interest within system), quality control measurements relevant field...
Proteus syndrome is a genetic condition with an estimated incidence of less than one in million. This sporadic and presents as progressive, mosaic overgrowth different tissues. Clinical manifestations are diverse, the reported involvement lungs, skin, blood cells, nervous system bones. Gynecologic have rarely been literature. case first to be literature woman diagnosed her prepubertal years presenting at 34 old cervical mass protruding from vagina. The patient sought medical intervention...