A5112128808- Sarcoma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Cardiac tumors and thrombi
- Vascular Tumors and Angiosarcomas
- CAR-T cell therapy research
- Surgical site infection prevention
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Soft tissue tumor case studies
- Bone Tumor Diagnosis and Treatments
- Cancer Genomics and Diagnostics
- Soft tissue tumors and treatment
- Cutaneous Melanoma Detection and Management
- Cancer, Hypoxia, and Metabolism
- Virus-based gene therapy research
- Cancer Mechanisms and Therapy
- Immunotherapy and Immune Responses
- Microbial metabolism and enzyme function
- Allergic Rhinitis and Sensitization
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Peking University
2015-2025
Peking University Cancer Hospital
2015-2025
Beijing Institute of Water
2021
Simcere Pharmaceutical (China)
2021
Soochow University
2008
Second Affiliated Hospital of Soochow University
2008
Several patient-derived tumor models have emerged recently. However, soft tissue sarcomas (STSs) present a challenge in developing preclinical drug-testing due to their non-epithelial and complex nature. Here, we report model termed tumor-like cell clusters (PTCs) derived from STS patients. PTCs result the self-assembly proliferation of mesenchymal stem cells (MSCs), epithelial cells, immune faithfully recapitulating morphology function original tumors. Through standardized culture...
Background Intratumoral oncolytic herpes simplex virus 2-GM CSF (OH2) injection has shown safety and antitumor efficacy in patients with solid tumors. Here, we examined the of OH2 as a single agent or combination HX008, an NMPA-approved PD-1 inhibitor, locally advanced metastatic sarcoma patients. Methods This multicenter, phase 1/2 trial enrolled injectable lesions, who had failed at least 1 more lines standard treatment. Patients were treated three dose levels (10 6 , 10 7 8 CCID 50 /mL)...
Abstract Purpose: To explore the efficacy and safety of TQB2450 combined with anlotinib in patients locally advanced or metastatic soft-tissue sarcoma (LA/M STS). Patients Methods: This was a single arm phase II study (TQB2450-Ib-02 study) performed at two hospitals China to assess potency LA/M STS. were previously unresponsive least one chemotherapy regimen. Anlotinib (12 mg every day) administered orally from day 1 14 3 weeks. by intravenous infusion 1,200 on The primary endpoint objective...
Three-dimensional (3D) culture models are considered to recapitulate the cell microenvironment in solid tumors, including extracellular matrix (ECM), cell-cell interactions, and signal transduction. These functions highly correlated with cellular behaviors contribute resistances against chemo- radio-therapies. However, biochemical effects mechanisms remain unknown soft sarcoma. Therefore, we developed an vitro 3D model of sarcoma analyze reasons radio-resistance therapies. Four lines,...
Abstract The biogenesis of autophagosomes provides the basis for macroautophagy to capture and degrade intracellular cargoes. Binding autophagy-related protein ATG8/LC3 autophagic membranes is essential autophagosome formation, which involves specific dynamic processing by cysteine protease ATG4. However, date, mechanism whereby ATG4 recruited membranes, interaction on its role in growth phagophore are not completely understood. Here, we used fluorescence recovery after photobleaching...
Abstract Background Adult head and neck rhabdomyosarcoma (HNRMS) is an exceptionally rare malignancy, there a paucity of data research dedicated to understanding its characteristics management in adult populations. This study aimed assess the outcomes identify survival predictors HNRMS. Methods We retrospectively evaluated 42 patients (> 16 years) with HNRMS who received radiotherapy (RT)-based treatment at our institute between 2008 2022. analysed clinical prognosis these patients,...
11515 Background: The combination of the anti-angiogenesis tyrosine kinase inhibitor (TKI), anlotinib, with anti-programmed death-ligand 1 (PDL1) antibody (TQB2450) demonstrated commendable antitumor efficacy in a phase II clinical trial for pan-sarcoma patients, particularly within alveolar soft part sarcoma (ASPS) cohorts (Liu et al., 2022, PMID: 35675031). An expansion ASPS cohort has been underway since 2019. Herein, we present observed this ASPS-specific cohort. Methods: patients naïve...
The goal of this study was to retrospectively analyze the efficacy and safety pembrolizumab in real-world treatment soft tissue sarcoma (STS).We analyzed 38 patients who suffered from STS received July 2017 December 2018 our hospital. We investigated influence clinical characteristics, timing, protocol on objective response rate (ORR). also factors affecting overall survival (OS) progression-free (PFS), as well occurrence severe adverse events (SAEs).The ORR 19.4% (7/36). ORRs first-line,...
11554 Background: At the 2024 ASCO conference, we reported preliminary results on efficacy and safety of IBI110 (anti-LAG-3 antibody) combined with sintilimab (anti-PD-1 in advanced alveolar soft part sarcoma (ASPS), which demonstrated an overall response rate (ORR) 48.1%, including three complete responses (CRs). Here, provide updated from this single-arm, phase II trial. Methods: Eligible patients metastatic or unresectable ASPS were assigned to two cohorts: cohort A (immune checkpoint...
11569 Background: Soft tissue sarcomas (STS) are rare malignancies with over 100 distinct histological subtypes. Their rarity and heterogeneity pose significant challenges to identifying effective therapies, approved regimens show varied responses. Several patient-derived tumor models have emerged recently. However, STS present a challenge in developing preclinical drug-testing due their non-epithelial complex nature. Methods: Here we report model termed tumor-like cell clusters (PTCs)...
e21567 Background: Radical inguinal lymph node dissection (rILND) is the standard procedure for malignant melanoma (MM) patients with clinically positive nodes (ILNs), but its precise anatomical boundaries remain unclear. This study aims to investigate lymphatic drainage pattern of in lower limb MM using definitive pathological evidence. Methods: A total 58 who underwent rILND were included this study. The ILNs categorized into five zones examination. Statistical analysis was performed...
<b>Objective:</b> Osteosarcoma is a common primary highly malignant bone tumor. Kinesin family member 18B (<i>KIF18B</i>) has been identified as potential oncogene involved in the development and metastasis of several cancer types. While KIF18B overexpression osteosarcoma tissue clearly detected, its specific function disease process remains to be established. <b>Methods:</b><i>KIF18B</i> expression was assessed tissues cells. We additionally evaluated effects on proliferation, migration,...
To assess the efficacy of conservative chemotherapy for inoperable desmoid tumor (DT) and analyze prognostic factors.From November 2008 to April 2016, 71 patients DT were treated with vinorelbine low-dose methotrexate in Department Bone Soft Tissue Tumors, Peking University Cancer Hospital & Institute, enrolled this retrospective study. The duration is one year. prognosis observed.Of patients, 55% female. Age onset varied from 1 47 years, median age was 14 years. Only 11 (15.5%) cases...
Alveolar soft part sarcoma (ASPS) is a translocation-associated soft-tissue tumor resistant to conventional cytotoxic agents. This report aims compare the efficacy of anlotinib versus pazopanib as targeted monotherapy in metastatic ASPS and determine impact drug dosage reduction on disease control.Sixteen 31 patients with were respectively treated at single institution. Objective response rate (ORR), progression-free survival (PFS), overall (OS) retrieved compared between both therapeutic...
11548 Background: TAEST16001 cells are genetically engineered autologous T expressing high-affinity NY-ESO-1-specific T-cell receptor (TCR) targeting NY-ESO-1 (expressed in a wide range of tumors) positive soft tissue sarcoma (STS) the context HLA-A*02:01. A phase I study patients with advanced STS (NCT04318964) demonstrated safety and preliminary indication efficacy at ASCO 2022. Here, we will present our encouraging IIa results. Methods: This is an open-labeled, single arm to evaluate...
Alveolar soft part sarcoma (ASPS) is an ultra-rare soft-tissue with a high rate of metastasis and no established treatment. This study aimed to explore the efficacy safety anlotinib (a tyrosine-kinase inhibitor) TQB2450 PD-L1 in ASPS patients.
Osteosarcoma (OS) is a high-grade, aggressive bone sarcoma. LncRNAs play key regulatory role in controlling biological and pathological processes. The expression of lncRNA SNHG9 varies among different cancer tissues, the OS progression unclear. In this study, we found overexpression tissues cells. addition, downregulated impaired proliferation, migration, invasion abilities was positively regulated by transcription factor SOX4. interacted with miR-214-5p as molecular sponge SOX4 identified...
Alveolar soft part sarcoma (ASPS) is a rare that has been shown to be highly effective antiangiogenic agents and immune checkpoint inhibitors, but most reported studies about ASPS were concentrated on adult population. In this study, we aimed describe the clinical features therapeutic outcomes of in children.We retrospectively reviewed records patients with our institution since Jan 2015. All included study pathologically confirmed aged under 12 years at time initial diagnosis. Demographic...
Identification of the biological targets a compound is paramount importance for exploration mechanism action drugs and development novel drugs. A concept Connectivity Map (CMap) was previously proposed to connect genes, drugs, disease states based on common gene-expression signatures. For new query compound, CMap-based method can infer its potential by searching similar with known (reference drugs) measuring similarities into their specific transcriptional responses between those reference...
The presence of large genomic rearrangements (LGRs) has been heavily investigated in breast and ovarian cancer. However, correlations between LGRs cancer types beyond these two have not extensively profiled, likely due to the highly inefficient methods detecting alterations. This study utilized next-generation sequencing (NGS) analyze classify germline LGR profile 17 025 patients across 22 types. We characterized newly identified based on predicted pathogenicity took a closer look at genes...
PD-1 inhibitor monotherapy is ineffective for metastatic leiomyosarcoma (LMS), but it remains unclear whether inhibitors demonstrate any efficacy when combined with chemotherapy. This study retrospectively evaluated pegylated liposomal doxorubicin (PLD) and dacarbazine (DTIC) with/without advanced/metastatic LMS patients treated in our single institution.The inclusion criteria were a confirmed histological diagnosis of LMS, treatment between January 2020 March 2022, measurable disease...