To evaluate the association between single nucleotide polymorphisms (SNPs) at 194 and 399 codons of XRCC1, risk severe acute skin oral mucosa reactions in nasopharyngeal carcinoma patients China.114 with were sequentially recruited this study. Heparinized peripheral blood samples taken for SNPs analysis before start radiation treatment. XRCC1 (194Arg/Trp 399Arg/Gln) gene analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Dermatitis upper neck mucositis...

<h3>Objective:</h3> Our aim was to test the hypothesis that fatty acid synthase (FASN) expression contributes radioresistance of nasopharyngeal carcinoma (NPC) cells and inhibiting FASN enhances radiosensitivity. <h3>Methods:</h3> Targeting using epigallocatechin gallate (EGCG) or RNA interference in NPC cell lines overexpress endogenous performed determine their effects on cellular response radiation <i>in vitro</i> MTT colony formation assays, vivo</i> xenograft animal models. Western...

Efficient and affordable electrocatalysts are a crucial part of rechargeable zinc air batteries (ZAB) to address the problems caused by sluggish activity oxygen reduction reaction (ORR) evolution (OER) on cathode. Anchoring noble metals transition-metal-based substances is promising strategy reinforce electrochemical reduce cost. Herein, we have developed subsequent spontaneous-redox load Pt nanoparticles with 3.75% containing NiFe-LDH nanoflakes boost ORR activity. After that, NiFe-LDH@...

In China, over 90% of esophageal cancer (EC) cases are squamous cell carcinoma (ESCC). ESCC is a frequently malignant tumor with poor prognosis despite the development comprehensive therapeutic strategies, for which there still lack effective prognostic factors. Previous studies found that abnormal expression TRPC1 closely related to proliferation, invasion, metastasis, and differentiation various tumors. However, relationship between currently unclear. The present study aimed clarify...

Background: Our previous study has shown that cadmium (Cd) exposure is not only a risk factor for nasopharyngeal carcinoma (NPC), but also correlated with the clinical stage and lymph node metastasis. However, underlying molecular events of Cd involved in NPC progression remain to be elucidated. Purpose: The objective this was decipher how impacts malignant phenotypes cells. Methods: cell lines CNE-1 CNE-2 were continuously exposed 1 μM chloride 10 weeks, designating as chronic treated cells...

Cadmium (Cd) exposure has been implicated in the etiology of esophageal squamous cell carcinoma (ESCC), albeit with inconsistent results from epidemiologic studies and without causal evidence. In this study, we explore relationship Cd development, progression therapeutic resistance ESCC. A total 150 ESCC patients 177 matched controls a coastal region high incidence China were included study. It was found that median blood level (BCL) significantly higher than controls. Odds ratios for risk...

Aims and Background It was documented that nasopharyngeal carcinoma (NPC) is associated with Epstein-Barr virus (EBV) EBV-encoded latent membrane protein-1 expression (LMP1) plays an important role in the pathogenesis of NPC. In preclinical studies, arsenic trioxide (As 2 O 3 ) has been identified as a promising anticancer agent for treatment The purpose this study to investigate if can inhibit LMP1 therefore lead growth inhibition NPC cells vitro. Methods LMP1-positive cells, HNE1-LMP1,...

Lymphatic metastasis is one of the main factors affecting prognosis in esophageal squamous cell carcinoma (ESCC). Vascular endothelial growth factor-C (VEGF-C) an important factor that promotes lymphangiogenesis. Survivin also plays a significant role lymphatic invasion. However, and mechanism their co-expression are still unclear ESCC. The purpose this study was to investigate whether VEGF-C survivin could be potential marker predict patient survival ESCC.The levels VEGF-C, vascular...

Despite improvements to radiotherapeutic strategies, resistance adjuvant chemotherapy remains the main problem underlying low 5-year survival rate in patients with nasopharyngeal carcinoma (NPC). In present study, human NPC cell line HNE1 was exposed gradually increasing concentrations of cisplatin (CDDP) order establish a drug-resistant sub-cell line, HNE1/CDDP. HNE1/CDDP cells exhibited multidrug and prolonged doubling time, as compared parent cells. Furthermore, pretreatment zoledronic...

Studies demonstrate that the serum level of cytokeratin 19 fragment antigen 21-1 ( CYFRA21-1 ) is high in various cancer types.As a novel epithelial cells derived tumor marker,detection great clinical significance for screening and diagnosis,curative effect evaluation,recurrent monitoring prognosis assessment patients. Key words: Serum;  Antigens, neoplasm;  Tumor markers, biological;  Diagnosis

Tumor suppressor of lung cancer 1 (TSLC1) mediates cell-cell and cell-extracellar matrix adhesion, cellular signal transduction immunoregulation, additionally plays a vital role in inhibiting proliferation, migration metastasis tumor cells. As novel gene, TSLC1 may be regarded as potential molecular marker for diagnosis pharmaceutical target. Consequently, to explore the functions mechanism initiation development carcinomas has become one popular researches currently. Key words:...

Numerous studies found that the content of peripheral blood circulating RNA in various cancer types is aberrant increased,which could be a potential biological diagnostic marker and therapeutic target.Detecting through molecular biology technology will provide sensitive efficient,convenient,specific,noninvasive minimally invasive therapy for early diagnosis detection,prognosis monitoring malignant tumor. Key words: Neoplasms;  Blood;  Nucleic acids;  Diagnosis

Presence of anaplastic lymphoma kinase (ALK) rearrangement is an indication for crizotinib in the treatment patients with advanced or metastatic lung adenocarcinoma. Here, we sought to elucidate association between clinicopathological features and ALK status Chinese adenocarcinoma harboring rearrangement.ALK was determined using immunohistochemistry (IHC) tumor tissues from 120 adenocarcinoma, further assessed by fluorescence situ hybridization (FISH) assay. The associations were...

Objective To evaluate the protein expression of chromosome 2 open reading frame 40 (C2orf40) in nasopharyngeal carcinoma (NPC) tissues and cells, to explore its association with cell diffe-rentiation clinicopathological features. Methods A total 122 patients NPC between January 2001 December 2003 were enrolled Cancer Hospital Shantou University Medical College. The paraffin-embedded tissue sections medical records collected. Twenty-five samples chronic nasopharyngitis used as...

Objective To explore the association between blood cadmium levels (BCLs) and clinicopathological characteristics of patients with breast cancer. Methods The specimens 186 diagnosed cancer were collected July December 2009. BCLs detected by graphite-furnace atomizer absorption spectrophotometer. Mann-Whitney U test Kruskal-Wallis H used to compare different clinical characteristics. Spearman rank correlation analysis was evaluate relationships some indices...