A5032123088- Neuroblastoma Research and Treatments
- Testicular diseases and treatments
- Pancreatic and Hepatic Oncology Research
- Glioma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Urological Disorders and Treatments
- Sarcoma Diagnosis and Treatment
- Abdominal Trauma and Injuries
- Renal and related cancers
- Central Venous Catheters and Hemodialysis
- Anesthesia and Neurotoxicity Research
- Cancer therapeutics and mechanisms
- Renal cell carcinoma treatment
- Cardiovascular Function and Risk Factors
- Gestational Trophoblastic Disease Studies
- Frailty in Older Adults
- Anesthesia and Sedative Agents
- Adrenal and Paraganglionic Tumors
- Anesthesia and Pain Management
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Thyroid and Parathyroid Surgery
- Cancer Risks and Factors
- Thyroid Cancer Diagnosis and Treatment
- Nutrition and Health in Aging
University of Messina
2007-2024
Bambino Gesù Children's Hospital
2015-2024
Istituto Ortopedico Gaetano Pini
2023
Istituti di Ricovero e Cura a Carattere Scientifico
2009-2022
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2019
University of Milan
2019
Lieber Institute for Brain Development
2018
Johns Hopkins University
2018
University of Reggio Calabria
2015
Ospedale A. Perrino
2012-2014
Teratomas demonstrate a benign clinical behavior, however they may recur with malignant components or as teratoma, and in small group of patients prognosis could be fatal. After the first Italian study, we collected cases alongside protocol for germ cell tumors.Patients teratoma were from 2004 to 2014. classified according WHO classifications, mature immature. Patients pathological aFP and/or bHCG, those component not included.The study enrolled 219 (150 mature, 69 immature teratomas) median...
Data on the efficacy and safety of anti PD-1 antibodies in children adolescents (CA) with melanoma are lacking. The aim this study was to determine outcomes CA patients receiving antibodies.
Malignant ovarian germ cell tumors (MOGCT) carry an excellent prognosis, and the treatment aims to achieve results with least possible treatment-related morbidity. The aim of this study was assess outcomes pediatric patients MOGCT.Patients were treated according their stage: surgery surveillance for stage I; a modified bleomycin-etoposide-cisplatin (BEP) regimen stages II (three cycles), III, IV cycles) on residual disease.Seventy-seven enrolled (median age 11.8 years), 26 dysgerminoma...
Background Salivary gland carcinomas are extremely rare in pediatric age. We report the clinical features of a series children/adolescents with salivary prospectively registered Italian TREP (Rare Tumors Pediatric Age) project. Procedures Diagnostic/therapeutic guidelines were developed and shared among oncology/surgical centers. Results Seventeen patients between 2000 2012, representing 19% cases expected to be seen based on epidemiological data. arose mainly parotid (14 cases). In most...
Proper securement of central venous catheters plays an important role in onco-hematological pediatric patients. A new subcutaneously anchored device has been recently introduced the clinical practice, and it extensively used children.In our study, we have retrospectively investigated safety effectiveness such device, reviewing experience three Italian oncological units. We considered only tunneled (cuffed or non-cuffed) inserted children with malignancy; all types were included analysis...
Objective To evaluate the long‐term results of patients who underwent bladder autoaugmentation (BA) in whom BA was used to treat a neuropathic secondary myelomeningocele, and presented with high‐pressure/poorly compliant bladder. Patients methods Eleven (eight girls three boys, mean age 12.8 years, follow‐up 6.6 years) were selected had undergone between June 1991 1994. At surgery, poorly leak point volume (LPV) 94 mL pressure (LPP) 58 cmH 2 O. None vesico‐ureteric reflux (VUR) at BA; five...
To determine objectively, using uroflowmetry, the functional results of tubularized-incised plate urethroplasty to repair midshaft-proximal hypospadias.Twenty-one patients (mean age 4 years, mean follow-up 1.8 years) were selected from those undergoing surgery between January 1996 and 1998 at our institution. All had hypospadias treated Snodgrass technique. Patients included if they able void volitionally no fistula. The flow pattern, maximum (Qmax) rate (Qave) measured; expressed as...
Posterior reversible encephalopathy syndrome (PRES) is one of the most common neurological complications in hematology-oncology pediatric patients. Despite an increasingly recognized occurrence, no clear consensus exists regarding how best to manage syndrome, because cases PRES have reported single-case reports or small series. Aim this paper identify incidence, clinical features, management, and outcome a large series patients.The occurred twelve centers Italian Association Pediatric...
Local control is always considered in metastatic neuroblastoma (NBL). The aim of this study to evaluate the impact radical surgery on survival children over 1 year age. Fifty-eight patients older than age with NBL were treated conventional plus high-dose chemotherapy or without addition local radiotherapy (RT, 21Gy). Surgery was classified as (complete resection and gross total resection) non-radical surgery. Kaplan-Meier method Cox proportional hazard model used calculate probability...
Abstract Background Gastrointestinal (GI) carcinomas are very rare in the pediatric and adolescent age range. We report clinical features, treatment, outcome of a series children adolescents with GI carcinoma prospectively registered Italian Tumori Rari Età Pediatrica (TREP) project. Methods The TREP project developed diagnostic therapeutic guidelines based on recommendations currently use for adults. Clinical data were centrally reviewed. Results Fifteen patients over years 2000–2016. Most...
ABSTRACT Aims: The prognostic role of BMI variation during and/or after treatments for early-stage breast cancer is still unknown. Patients & methods: χ 2 test was conducted to explore the correlation between recurrence and changes in 520 patients. Cox proportional hazard models were used analyze association changes, baseline BMI, known factors recurrences. Results: gain significant determinant recurrences (p = 0.0008). In multivariate analyses, more than 5.71% associated with higher...
Thyroid gland malignancies are rare in pediatric patients (0.7% of tumors); only 1.8% observed aged <20 years, with a higher prevalence recorded women and adolescents. Risk factors include genetic syndromes, MEN disorders, autoimmune diseases, exposure to ionizing radiation. Radiotherapy is also associated an increased risk secondary thyroid cancer. This study describes the clinical features surgical outcomes primary tumors patients.Institutional data were collected from eight international...
It is estimated that 10-50% of interventions can generate persistent post-surgical pain. Chronic post-mastectomy pain a condition persisting for at least three months after surgery. has been shown physical activity in the cancer patient allows improvement symptom. The aim this study was to evaluate effects on intensity and interference chronic quality life women underwent mastectomy needed breast removal. secondary objective measure inflammatory oxidative markers same population. A Numeric...
Although pediatric malignant extracranial germ-cell tumors (meGCTs) are among the most chemosensitive solid tumors, a group of patients relapse and die disease. To identify new markers predicting clinical outcome, we examined prognostic relevance tumor-infiltrating T lymphocytes (TILs) expression PD-1 PD-L1 in cohort meGCTs by situ immunohistochemistry. MeGCTs were variously infiltrated cell-subtypes according to tumor subtype, location age at diagnosis. We distinguished three different...
Solid pseudopapillary pancreatic tumors (SPPT) are an extremely rare entity in pediatric patients. Even if the role of radical surgical resection as primary treatment is well established, data about follow-up after children scant.A retrospective review from Italian Pediatric Rare Tumor Registry (TREP) was performed. Short-term (<30 days) and long-term complications different resections, were evaluated.From January 2000 to present, 43 patients (male:female = 8:35) enrolled. The median age at...
Primary melanocytic neoplasms are rare in the pediatric age. Among them, pattern of neoplastic meningitis represents a peculiar diagnostic challenge since neuroradiological features may be subtle and cerebrospinal fluid analysis not informative. Clinical misdiagnosis with tuberculous has been described few cases, leading to significant delay appropriate management patients. We describe case child primary leptomeningeal melanoma (LMM) that was initially misdiagnosed meningitis. review...
Background and Aims: Pediatric adrenocortical tumors (ACTs) are very rare endocrine neoplasms in childhood. In this study, we performed a retrospective analysis of children with ACT treated at our institution by examining clinical genetic disease features, treatment strategies, outcomes. Methods: We retrospectively analyzed cohort 13 the Bambino Gesù Children's Hospital from November 2010 to March 2020. Results: The median age diagnosis was 17 months (range = 0-82 months). female: male ratio...
Pheochromocytomas (PCs) are neuroendocrine tumors arising from the chromaffin cells of adrenal gland, and paragangliomas (PGLs) their extra-adrenal counterparts ganglia along sympathetic/parasympathetic chain. Surgery is cornerstone treatment. A sporatic or inherited germline mutation commonly associated.Among over 1000 patients registered into Tumori Rari in Età Pediatrica-rare pediatric age project-from 2000 to 2019, 50 were affected by PC/PGL. All clinical therapeutic data...
Abstract Aim Activity and toxiciy of gefitinib in combination with topotecan cyclophosphamide (CPA) were evaluated a case‐series relapsed neuroblastoma (NB) patients. The vitro activity the was also assessed. Procedure Gefitinib (250 mg/day), (0.8 mg/m 2 /day), CPA (50 /day) (GTC) administered orally for 14 consecutive days out 28 days. Antitumor as single agent either or assessed panel NB cell lines. Results Ninety‐two courses given 10 Grade 4 neutropenia observed 7/92 (8%) grade...