A5103148085- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Receptor Mechanisms and Signaling
- Circadian rhythm and melatonin
- Neural dynamics and brain function
- Tryptophan and brain disorders
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Neural and Behavioral Psychology Studies
- Neuroendocrine regulation and behavior
- Cerebral Palsy and Movement Disorders
- RNA modifications and cancer
- Probiotics and Fermented Foods
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Attention Deficit Hyperactivity Disorder
- Gut microbiota and health
- Nerve injury and regeneration
- Neonatal Respiratory Health Research
- Cystic Fibrosis Research Advances
- Functional Brain Connectivity Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Biomarkers in Disease Mechanisms
- Sleep and related disorders
Center for Life Sciences
2024
Tsinghua University
2024
Weifang Medical University
2023
Nanchang University
2015-2023
Dalhousie University
2001
Adverse early-life experience such as depriving the relationship between parents and children induces permanent phenotypic changes, impairs cognitive functions associated with prefrontal cortex (PFC). However, underlying mechanism remains unclear. In this work, we used rat neonatal maternal separation (NMS) model to illuminate whether how NMS in early life affects functions, what cellular molecular is. We showed that pups separated from their dam 3 h daily during first postnatal weeks alters...
Abstract The circadian pacemaker housed in the suprachiasmatic nucleus (SCN) synchronizes daily sleep–wake cycles, presumably by modulating regulatory system, including ventrolateral preoptic area (VLPO) neurons. We used whole‐cell patch‐clamp recording to study projections from SCN VLPO horizontal slices of rat hypothalamus. Single‐pulse stimulation region elicited postsynaptic currents (PSCs) 20 66 neurons (30%) recorded within as verified intracellular biocytin labelling. At a holding...
Abstract Myelin of the central nervous system exhibits strong plasticity, and skill learning exercise promotes oligodendrogenesis adaptive myelination. Increasing evidence shows that brain structures functions are affected by physical activity. However, impact voluntary activity on myelination its underlying mechanism remains unclear. The present study aimed to investigate effect wheel running (VWR) in mice. Adult C57BL/6 J mice were placed wheels allowed for 2 weeks. levels detected using...
Intestinal microorganisms play an important role in regulating the neurodevelopment and brain functions of host through gut-brain axis. Lactobacillus, one most representative intestinal probiotics, produces effects on human physiological functions. Our previous studies reveal that Lactobacillus plantarum WLPL04 has a series beneficial actions, such as antiadhesion pathogens, protection from harmful effect sodium dodecyl sulfate, anti-inflammatory stress Caco2 cells. However, its remain...
Inflammasomes are a central component of innate immunity and play vital role in regulating immune response. Activation inflammasomes is also indispensable for adaptive immunity, modulating the development response immunity. Recently, increasing studies have shown that metabolic alterations adaptations strongly influence regulate differentiation function system. In this review, we will take holistic view how bridge (especially T cell) crosstalk with signals during responses. And, special...
Early-life stress has long-term impacts on the structure and function of anterior cingulate cortex (ACC), raises risk adult neuropsychiatric disorders including social dysfunction. The underlying neural mechanisms, however, are still uncertain. Here, we show that, in female mice, maternal separation (MS) during first three postnatal weeks results impairment accompanied with hypoactivity pyramidal neurons (PNs) ACC. Activation ACC PNs ameliorates MS-induced impairment. Neuropeptide Hcrt,...
Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder that primarily affects older individuals. N7-methylguanosine (m7G) common RNA chemical modification impacts the development of numerous diseases. Thus, our work investigated m7G-related AD subtypes established predictive model.The datasets for patients, including GSE33000 GSE44770, were obtained from Gene Expression Omnibus (GEO) database, which derived prefrontal cortex brain. We performed differential analysis...
Abstract It is well known that β3-adrenoceptor (β3-AR) in many brain structures including prefrontal cortex (PFC) involved stress-related behavioral changes. SR58611A, a brain-penetrant β3-AR subtypes agonist, revealed to exhibit anxiolytic- and antidepressant-like effects. Whereas activation of exerts beneficial effects on cognitive function, the underlying cellular molecular mechanisms have not been fully determined. In this study, whole cell patch-clamp recordings were employed...
Abstract The cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-binding chloride channel that regulated by intracellular cAMP/PKA phosphorylation. CFTR widely expressed in peripheral tissues and organs of mammals plays a vital role maintaining balance cellular homeostasis. While preliminary studies have identified expression the central nervous system (CNS), it not clear whether this also modulates neural network cerebral cortex regulating level neurons. In study, we...
Abstract The prefrontal cortex (PFC) is a key brain region mediating many cognitive functions, and its structures functions are particularly vulnerable to stress. Chronic social defeat stress (CSD) has been proposed as model of anxiety/depressive-like behaviors. In the present study, we examined whether CSD affects myelination in medial PFC (mPFC) mice. Our results show that dramatically reduced myelin basic protein (MBP) staining mPFC, with no effect on MBP-labeling motor cortex, striatum,...