A5101743557- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- RNA Interference and Gene Delivery
- Immune cells in cancer
- Influenza Virus Research Studies
- Hepatitis B Virus Studies
- Cancer Research and Treatments
- Animal Virus Infections Studies
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Respiratory viral infections research
- Viral Infections and Vectors
- Liver Disease Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cell Image Analysis Techniques
- Xenotransplantation and immune response
- Leptospirosis research and findings
- Drug-Induced Hepatotoxicity and Protection
- Wound Healing and Treatments
Center for Life Sciences
2021-2024
Tsinghua University
2021-2024
Xiamen University
2024
BOE Technology Group (China)
2024
Washington University in St. Louis
2020-2023
Wuhu No 1 People's Hospital
2021
Xian Yang Central Hospital
2021
People's Liberation Army 401 Hospital
2021
Chinese People's Liberation Army
2021
Union Hospital
2019
Significance Cancer cells acquire distinct metabolic adaptations for survival. However, how remodeling enables cancer to survive genomic instability stress remains poorly understood. This report shows that p53 loss or mutation reprograms folate metabolism through MTHFD2. Moreover, MTHFD2 not only influences reactive oxygen species but also unexpectedly participates in nonhomologous end joining (NHEJ) response DNA damage. Down-regulation of preferably induces apoptosis and cell proliferative...
The diversity of mononuclear phagocyte (MNP) subpopulations across tissues is one the key physiological characteristics immune system. Here, we focus on understanding metabolic variability MNPs through network analysis applied to three large-scale transcriptional datasets: introduce (1) an ImmGen MNP open-source dataset 337 samples 26 tissues; (2) a myeloid subset Phase I (202 samples); and (3) mouse single-cell RNA sequencing (scRNA-seq) (51,364 cells) assembled based Tabula Muris Senis. To...
CTLA4Ig has been successfully used in the clinic for suppression of T cell activation. However, patients treated with experienced reduced incidence tumors than predicted, but underlying mechanism remains unknown. In this paper, we showed that brief administration significantly tumor metastasis and prolonged survival host mice bearing B16 melanoma. Depletion NK cells prior to eliminated CTLA4Ig-mediated anti-tumor activity. enhanced cytotoxicity via up-regulation effecter molecules CD107a...
Inflammasomes are a central component of innate immunity and play vital role in regulating immune response. Activation inflammasomes is also indispensable for adaptive immunity, modulating the development response immunity. Recently, increasing studies have shown that metabolic alterations adaptations strongly influence regulate differentiation function system. In this review, we will take holistic view how bridge (especially T cell) crosstalk with signals during responses. And, special...
Growing findings have demonstrated that interferon regulatory transcription factor (IRF) family members are linked to the progression of various cancers. However, roles IRFs in clear cell renal carcinoma (ccRCC) remain undefined. Herein, we conducted a comprehensive analysis using bioinformatics method evaluate expression patterns, clinical significance, and regulation IRFs-related mechanisms patients with ccRCC.Data from Cancer Genome Atlas (TCGA), International Consortium (ICGA), Gene...
Abstract Liver hepatocellular carcinoma (LIHC) is one of the most frequently occurring primary malignant liver tumors and seriously harms people’s health in world. Methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L) has been shown to be associated with colon cancer cell proliferation, colony formation invasion. In present study, a total 370 LIHC 51 normal samples data were downloaded from The Cancer Genome Atlas (TCGA) database. Bioinformatics immunohistochemistry (IHC) analysis showed...
Cell state transition is one of the fundamental events in development multicellular organisms, and trajectory path has recently attracted much attention. With accumulation large amounts "-omics" data, it becoming possible to get insights into molecule mechanisms underlying transitions between cell states. Here, we present CSTEA (Cell State Transition Expression Atlas), a webserver that organizes, analyzes visualizes time-course gene expression data during differentiation, cellular...
Abstract We dissect metabolic variability of mononuclear phagocyte (MNP) subpopulations across different tissues through integrative analysis three large scale datasets. Specifically, we introduce ImmGen MNP Open Source dataset that profiled 337 samples and extended previous effort which included 202 phagocytes their progenitors. Next, analysed Tabula Muris Senis to extract data for 51,364 myeloid cells from 18 tissues. Taken together, a compendium assembled in this work covers phagocytic...
Since COVID‐19, an anti‐bacteria and anti‐virus is becoming one of most important characters for products, including consumer electronics. This manuscript reviews several antibacterial (AA) solutions different type electrical communication devices (ECDs), such as mobile, tablet personal computer, monitor so on. Meanwhile, AA material candidates their adapter volume fabrication process will introduced compared by analyzing its principle, ratio, lifespan, optical properties, application...
Abstract The regulatory activities of mouse CD4+Foxp3+ T cells on various immune cells, including NK have been well documented. Under some conditions, conventional CD4+Foxp3- are able to acquire inhibitory function other but their roles in controlling innate poorly defined. As a potential cellular therapy for cancer, ex vivo activated effector often infused back suppress tumor growth and metastasis. Whether such could affect cell anti-tumor is unclear. We found that mitogen-activated...
Typhoid fever caused by Salmonella Typhi is still a major public health problem in developing countries. In this study, we constructed genetically modified strain expressing O-specific polysaccharides (OPS) antigen conjugated to carrier, recombinant Pseudomonas aeruginosa exotoxin A(rEPA N29). The conjugates (OPS-rEPA N29) were further purified and evaluated for their immunogenicity. results of ELISA showed that the evoked higher titers IgG than OPS, suggesting rEPAN29 increased...
Efficient activation of CD8+ T cells is critical for bacterial resistance and eradicating malignancy in the body. Here, we present a step-by-step protocol to use Listeria monocytogenes expressing OVA (LmOVA) stimulate endogenous cells. We describe steps adoptive transfer OT-I CD45.1 mice then detail detection antigen-specific response LmOVA. For complete details on execution this protocol, please refer Wu et al. (2021).
A significant transcription factor that is involved in the regulation of numerous cellular functions tumor suppressor p53. In disease, p53 weakens cell expansion light different boosts, including DNA harm, supplement hardship, hypoxia, and hyperproliferative signs, along these lines forestalling growth arrangement. It was detailed proficiency Microarray ABI 310 framework distinguishing proof a wide range quality transformations. analysis were used this study to find gene mutations archived...