A5076828160- DNA Repair Mechanisms
- Cancer Treatment and Pharmacology
- Cancer therapeutics and mechanisms
- Synthesis of Organic Compounds
- Microbial Natural Products and Biosynthesis
- Bioactive natural compounds
- Cancer-related Molecular Pathways
- Antioxidant Activity and Oxidative Stress
- Mitochondrial Function and Pathology
- PI3K/AKT/mTOR signaling in cancer
- Protein Interaction Studies and Fluorescence Analysis
- Cancer, Hypoxia, and Metabolism
- Vitamin C and Antioxidants Research
- Nanoparticle-Based Drug Delivery
- Microtubule and mitosis dynamics
- ATP Synthase and ATPases Research
- RNA Interference and Gene Delivery
- Retinoids in leukemia and cellular processes
- Enzyme Structure and Function
- Iron Metabolism and Disorders
- Biochemical and Molecular Research
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemical compounds biological activities
- Bauxite Residue and Utilization
- Bioactive Natural Diterpenoids Research
California Polytechnic State University
2025
Louisiana State University in Shreveport
2013-2024
University of Virginia
2000
University of South Carolina
1999-2000
Mitochondrial complex II (CII) has been recently identified as a novel target for anti-cancer drugs. Mitochondrially targeted vitamin E succinate (MitoVES) is modified so that it preferentially localized to mitochondria, greatly enhancing its pro-apoptotic and activity. Using genetically manipulated cells, MitoVES caused apoptosis generation of reactive oxygen species (ROS) in CII-proficient malignant cells but not their CII-dysfunctional counterparts. inhibited the dehydrogenase (SDH)...
Epirubicin (Epr) is an effective chemotherapeutic drug; however, the clinical amenability of Epr limited by its highly toxic interaction with normal cells. This toxicity can be decreased utilizing nanocarriers and targeted drug delivery systems. work describes approach for via encapsulation in horse spleen apoferritin (HsAFr) cavity. The was achieved disassembling into subunits at pH 2 followed reformation 7.4 presence Epr. surface HsAFr-encapsulated modified folic acid (FA) optimal...
The interactions of small molecule drugs with plasma serum albumin are important because the influence such on pharmacokinetics these therapeutic agents. 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR) is one drug candidate that has recently gained attention for its promising clinical applications as an anti-cancer agent. This study sheds light upon key aspects AICAR’s pharmacokinetics, which not well understood. We performed in-depth experimental and computational binding analyses...
Wnt/beta-Catenin signaling plays a critical role in prostate cancer (PCa) progression, yet its precise contributions neuroendocrine (NEPCa) remain incompletely understood. In this study, we utilized TRAMP/Wnt-reporter mice to monitor activity and investigated transcriptional alterations associated with NEPCa development. RNA sequencing pathway enrichment analyses identified neuroactive ligand-receptor interaction, MAPK, calcium, cAMP as key pathways enriched NEPCa. Although Wnt was not among...
Vitamin E (VE) analogues, epitomized by alpha-tocopheryl succinate (alpha-TOS), are proapoptotic agents with selective antineoplastic activity. The molecule of alpha-TOS comprises several structurally and functionally distinct moieties that can be modified in order to yield analogues higher In find apoptogenic efficacy, we prepared novel compounds where the ester bond was replaced an amide bond. All these were significantly more than their counterparts, maleyl being most effective....
In the present work, folic acid-modified human serum albumin conjugated to cationic solid lipid nanoparticles were synthesized as nanocarriers of mitoxantrone for treatment breast cancer.Dual-targeted drug delivery is a new dosing strategy that frequently used enhance therapeutic efficacy anticancer drugs.Dual targeting cancer cells was achieved by dual tagging and acid on surface nanoparticles.The targeted drug-loaded nanocomplexes characterized using transmission electron microscopy along...
Various nano-sized protein and lipid complexes are being investigated as drug delivery systems. The encapsulation of more than one in a single nanocomplex carrier could enhance the therapeutic potency afford synergistic effects. In this study, we developed novel protein-lipid controlled system for two important cancer drugs, doxorubicin (DOX) mitoxantrone (MTO). Apoferritin (AFr) functionalized with folic acid (FA) was used to encapsulate DOX create targeted nanocomplexes (TPNs). second...
Fusarochromanone (FC101) is a small molecule fungal metabolite with host of interesting biological functions, including very potent anti-angiogenic and direct anti-cancer activity. Herein, we report that FC101 exhibits in-vitro growth inhibitory effects (IC50 ranging from 10nM-2.5 μM) against HaCat (pre-malignant skin), P9-WT (malignant MCF-7 (low malignant breast), MDA-231 SV-HUC (premalignant bladder), UM-UC14 PC3 prostate) in time-course dose-dependent manner, the cells being most...
// Ying Gu 1, 2 , Mansoureh Barzegar Xin Chen Yang Wu Chaowei Shang 2, 3 Elahe Mahdavian 4 Brian A. Salvatore Shanxiang Jiang 1 Shile Huang Laboratory of Veterinary Pharmacology and Toxicology, College Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, P. R. China Department Biochemistry Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA, USA Feist-Weiller Cancer Chemistry Physics, Correspondence to: Jiang, e-mail: nauvy@sina.com Huang,...
Fungal metabolites continue to show promise as a viable class of anticancer agents. In the present study, we investigated efficacy fungal metabolite, fusarochromanone (FC101), for its antitumor activities in glioblastomas, which have median survival less than two years and poor clinical response surgical resection, radiation therapy chemotherapy. Using clinically applicable doses, demonstrated that FC101 induced glioblastoma apoptotic cell death via caspase dependent signaling, indicated by...
The role of Ser 167 Escherichia coli thymidylate synthase (TS) in catalysis has been characterized by kinetic and crystallographic studies. Position variants including S167A, S167N, S167D, S167C, S167G, S167L, S167T, S167V were generated site-directed mutagenesis. Only S167C complemented the growth thymidine auxotrophs E. medium lacking thymidine. Steady-state analysis revealed that mutant enzymes exhibited kcat values 1.1−95-fold lower than wild-type enzyme. Relative to TS, Km for...
Fusarochromanone (FC101), a mycotoxin produced by the fungus Fusarium equiseti, is frequently observed in contaminated grains and feedstuffs, which toxic to animals humans. However, underlying molecular mechanism remains be defined. In this study, we found that FC101 inhibited cell proliferation induced death COS7 HEK293 cells concentration-dependent manner. Flow cytometric analysis showed G1 cycle arrest apoptosis cells. Concurrently, downregulated protein expression of cyclin D1,...
Anaplastic thyroid cancer (ATC) is among the most aggressive of human cancers, and currently there are few effective treatments for patients. YM155, first identified as a survivin inhibitor, was highlighted in high-throughput screen performed by National Cancer Institute, killing ATC cells vitro vivo. However, no association between expression response to YM155 clinical trials, has been mostly abandoned development despite favorable pharmacokinetic toxicity profiles. Currently, alternative...
We present a new highly interdisciplinary project-based course in computer aided drug discovery (CADD). This was developed response to call for alternative pedagogical approaches during the COVID-19 pandemic, which caused cancellation of face-to-face summer research program sponsored by Louisiana Biomedical Research Network (LBRN). The integrates guided and educational experiences chemistry, biology, science students. implement research-based methods with publicly available tools...
Fusarochromanone is an experimental drug with unique and potent anti-cancer activity. Current cancer therapies often incorporate a combination of drugs to increase efficacy decrease the development resistance. In this study, we used combinations cellular phenotypic screens address important questions about FC101′s mode action its potential therapeutic synergies in triple negative breast (TNBC). We hypothesized that activity against TNBC similar mTOR inhibitor, everolimus, because FC101...
Abstract Fusarochromanone (FC101) is a mycotoxin produced by Fusarium equiseti. Contamination of FC101 occurs frequently in grains and feedstuffs, which has been found to cause tibial dyschondroplasia chickens Kashin-Beck disease children. However, little known about the toxicity kidney. In this study, we that inhibited cell proliferation induced death monkey kidney fibroblasts (COS7) concentration-dependent manner. Furthermore, arresting cells G1 phase cycle, was associated with reduced...