A5103252590- Cardiac Arrest and Resuscitation
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Monoclonal and Polyclonal Antibodies Research
- Colorectal Cancer Treatments and Studies
- Allergic Rhinitis and Sensitization
- Cancer Genomics and Diagnostics
- Traumatic Brain Injury Research
- Gastric Cancer Management and Outcomes
- Advanced Breast Cancer Therapies
- Breast Cancer Treatment Studies
- Cardiac Arrhythmias and Treatments
- Phytochemicals and Antioxidant Activities
- Chronic Myeloid Leukemia Treatments
- COVID-19 Clinical Research Studies
- Dermatologic Treatments and Research
- Long-Term Effects of COVID-19
- Mycobacterium research and diagnosis
- Quinazolinone synthesis and applications
- Immune Response and Inflammation
- Ocular Surface and Contact Lens
- Trauma and Emergency Care Studies
- Diagnosis and treatment of tuberculosis
- Tuberculosis Research and Epidemiology
- Suicide and Self-Harm Studies
Kobe City Medical Center General Hospital
2022-2023
Kyoto University
2022-2023
Daiichi Sankyo (United States)
2023
Keio University Shonan Fujisawa
2023
Keio University
2022
Tokyo Metropolitan Bokutoh Hospital
2019-2022
Daiichi-Sankyo (Japan)
2019-2022
Nihon University
2020
Nippon Medical School
2020
Takeda (Japan)
2020
Abstract Experiences during brain development may influence the pathogenesis of developmental disorders. Thus, social isolation (SI) rearing after weaning is a useful animal model for studying pathological mechanisms such psychiatric diseases. In this study, we examined effect SI on neurogenesis in hippocampal dentate gyrus (DG) relating to memory and emotion‐related behaviors. When newly divided cells were labeled with 5‐bromo‐2′‐deoxyuridine (BrdU) before SI, number BrdU‐positive rate...
Reactive arthritis is a disease with the clinical triad of arthritis, urethritis, and conjunctivitis (1). The onset often preceded by bacterial infections Campylobacter, Chlamydia, Salmonella, Shigella, or Yersinia, either in urogenital gastrointestinal tract (2,3). HLA–B27 strongly associated reactive so that this considered as one HLA–B27positive spondylarthropathies. Although pathogenesis remains imperfectly understood, trigger systemic immunoreactions, overproduction proinflammatory...
Objectives. No objective method to measure skin involvement in SSc has been established. We developed a novel using computer-linked device simultaneously quantify physical properties of the such as hardness, elasticity and viscosity.
Flavonoids are nutrients that exert anti-allergic effects. We investigated the preventative effect of enzymatically modified isoquercitrin (EMIQ), a flavonoid, to relieve symptoms Japanese cedar pollinosis. In parallel-group, double-blind placebo-controlled study design, 24 subjects with pollinosis took 100 mg EMIQ or placebo for 8 weeks, starting 4 weeks prior onset pollen release. Subjective symptoms, ADL scores and usage drugs were recorded daily, QOL score was obtained every weeks. Blood...
Patients with massive pulmonary embolism (PE) have poor outcomes and their management remains challenging. An interventional radiology (IVR)-computed tomography (CT) system available in our emergency room (ER) allows immediate access to CT extracorporeal membrane oxygenation (ECMO) safe cannulation under fluoroscopy. We aimed determine if initial treatment this "hybrid ER" is helpful patients PE requiring cardiopulmonary resuscitation (ECPR).The records of transferred hybrid ER between...
An ongoing outbreak of a novel coronavirus disease (coronavirus 2019, COVID-19) has become global threat. While clinical reports from China to date demonstrate that the majority cases remain relatively mild and recover with supportive care, it is also crucial be well prepared for severe warranting intensive care. Initiating appropriate infection control measures may not always achievable in primary care or acute-care settings.A 45-year-old man was admitted unit due pneumonia, later confirmed...
<i>Background:</i> Flavonoids exert antiallergic and antioxidant effects. We investigated the efficacy of enzymatically modified isoquercitrin (EMIQ), a flavonoid, to relieve symptoms pollinosis. <i>Methods:</i> In parallel-group, double-blind placebo-controlled study design, 20 subjects with Japanese cedar pollinosis took two capsules daily 100 mg EMIQ or placebo for 8 weeks during pollen season. Subjective activities living (ADL) scores were recorded every day,...
1020 Background: DESTINY-Breast04 (NCT03734029) showed improved progression-free survival (PFS) and overall for T-DXd vs TPC in pts with HER2-low (IHC 1+ or 2+/ISH-negative) mBC. We present exploratory biomarker analysis HER2-low, HR+ Methods: Biopsy specimens collected from 326 after prior treatment were analyzed using RNA-sequencing intrinsic subtypes estimated by PAM50 gene expression. ESR1 PIK3CA mutations known alterations associated resistance to CDK4/6 inhibitors (CDK4/6i) assessed...
Interferon gamma (IFN-gamma) production is a critical step of antituberculosis (anti-TB) immune response. The purpose this study was to determine the influences biologics, including interleukin (IL)-6 receptor-inhibitor tocilizumab (TCZ), and tumor necrosis factor (TNF) antagonists infliximab (INF) etanercept (ETA), on Mycobacterium tuberculosis (MTB) antigen-induced IFN-gamma production. MTB antigen (ESAT-6 CFP-10)-induced IFN-gamma-releasing assay performed with or without addition...
1036 Background: Trastuzumab deruxtecan (T-DXd; DS-8201) is an antibody-drug conjugate composed of anti-HER2 antibody, a cleavable linker, and cytotoxic topoisomerase I inhibitor. In the pivotal DESTINY-Breast01 trial, efficacy T-DXd in HER2-positive metastatic breast cancer (mBC) was demonstrated, with objective response rate (ORR) 60.9% median progression-free survival (mPFS) 16.4 months. Methods: single-group, open-label, multicenter, phase II trial 184 patients mBC previously treated...
Overgrowth of the synovium plays an important role in pathogenesis rheumatoid arthritis (RA). Platelet-derived growth factor (PDGF) is one most potent mitogenic factors synovial cells, and imatinib mesylate (imatinib) a specific inhibitor PDGF receptor tyrosine kinase. The aim this study was to elucidate anti-rheumatic activity imatinib. vivo effects were assessed by evaluating sequential manifestation adjuvant-induced rats using paw volume clinical scores. Imatinib found inhibit rat...
Gleditsia sinensis is widely used as a medicinal plant in Asia, especially China. Triterpenes, alkaloids, and sterols were isolated from species. Among them, triterpenoid saponins are very important metabolites owing to their various pharmacological activities. However, the saponin biosynthesis pathway has not been well characterized. In present study, we performed de novo transcriptome assembly for 14.3 Gbps of clean reads sequenced nine tissues G. sinensis. The results showed that 81,511...
Interferon gamma (IFN-γ) production is a critical step of antituberculosis (anti-TB) immune response. The purpose this study was to determine the influences biologics, including interleukin (IL)-6 receptor-inhibitor tocilizumab (TCZ), and tumor necrosis factor (TNF) antagonists infliximab (INF) etanercept (ETA), on Mycobacterium tuberculosis (MTB) antigen-induced IFN-γ production. MTB antigen (ESAT-6 CFP-10)-induced IFN-γ-releasing assay performed with or without addition biologics (TCZ,...
Journal Article Imatinib mesylate inhibited rat adjuvant arthritis and PDGF-dependent growth of synovial fibroblast via interference with the Akt signaling pathway Get access Fumitaka Terabe, Terabe Department Respiratory Medicine, Allergy Rheumatic Disease, Osaka University Graduate School 2-2 Yamadaoka, Suita, 565-0871, Japan Search for other works by this author on: Oxford Academic Google Scholar Masayasu Kitano, Kitano Division Rheumatology, Internal Hyogo College Hyogo, Mari Kawai,...