In humans, there is a significant decrease in serum T(3) and increase rT(3) at different time points after myocardial infarction, whereas TSH T(4) remain unaltered. We report here course study of pituitary-thyroid function thyroid hormone metabolism rats subjected to infarction by left coronary ligation (INF). INF- sham-operated animals were followed serial deiodination assays tests, just before, 1, 4, 8, 12 wk surgery. At 4 INF, liver type 1 deiodinase activity was significantly lower,...

Postinfarct congestive heart failure is one of the leading causes morbidity and mortality in developed developing countries. The main purpose this study was to investigate whether transplantation bone marrow stromal cells (BMSC) directly into myocardium could improve performance healed infarcted rat hearts. Cell culture medium with or without BMSC injected borders cardiac scar tissue 4 wk after experimental infarction. Cardiac evaluated 2 cellular (n = 10) injection by electro-...

What is the central question of this study? The relationship between thyroid system and sleep deprivation has seldom been assessed in literature, mounting evidence exists that disturbances influence human lifestyles. aim study was to investigate hypothalamic-pituitary-thyroid axis hormone metabolism sleep-deprived sleep-restricted rats. main finding its importance? Central hypothyroidism high thyroxine (T4 ) 3,5,3'-triiodothyronine (T3 activation brown adipose tissue were observed following...

Thyroid hormone accelerates energy expenditure (EE) and is critical for cold-induced thermogenesis. To define the metabolic role played by thyroid in dissipation of calories from diet, hypothyroid mice were studied 60 d a comprehensive lab animal monitoring system. Hypothyroidism decreased caloric intake body fat while down-regulating genes skeletal muscle but not brown adipose tissue thermogenic programs, without affecting daily EE. Only at thermoneutrality (30 C) did exhibit slower rate...

A BSTRACT It is known that the planned exposure to high temperatures favors organic adaptations heat and promotes important hypotensive effects. The increasing number of heart disease patients deaths due ischemic events mobilizes studies aimed at discovering improving new therapeutic procedures. Considering costs pharmacological therapies, nonpharmacological strategies are a high-value low-cost alternative. Combined with effects physical exercise, therapy (HT) can significantly contribute...

Cardiac injury induces myocardial expression of the thyroid hormone inactivating type 3 deiodinase (D3), which in turn dampens local signaling. Here, we show that D3 gene (Dio3) is a tissue-specific imprinted heart, and thus, heterozygous knockout (HtzD3KO) mice constitute model cardiac inactivation an otherwise systemically euthyroid animal. HtzD3KO newborns have normal hearts but later develop restrictive cardiomyopathy due to cardiac-specific increase signaling, including fibrosis,...

Aim Thyroid dysfunctions can increase the risk of myocardial ischemia and infarction. However, repercussions on cardiac ischemia/reperfusion (IR) injury remain unclear so far. We report here effects hypothyroidism thyrotoxicosis in susceptibility to IR isolated rat hearts compared euthyroid condition potential role antioxidant enzymes. Methods Hypothyroidism were induced by administration methimazole (MMZ, 300 mg/L) thyroxine (T4, 12 mg/L), respectively drinking water for 35 days. Isolated...

Few data are available on adolescent users because most behavioral studies anabolic-androgenic steroids (AAS) abuse have been performed in adults. Studies evaluating the impact of long-term effects AAS prepubertal phase even more uncommon. Accordingly, this study was developed to test hypothesis that changes induced by use during may be noted adult when treatment cycle is discontinued. Therefore, not only but also possible autonomic and electrolyte disorders were evaluated. For purpose, we...

We report results obtained with sera from 58 chronic chagasic patients that were evaluated for effects on heart rate and atrioventricular (AV) conduction in isolated rabbit hearts screened the presence of muscarinic beta-adrenergic activity. show 26 decreased rate, while 10 increased it 22 had no effect. Additionally, 20 blocked AV conduction. Muscarinic activation seems to be involved both effects, but is not only mechanism, since atropine did antagonize decrease 23% or block 40%. Sera...

Background/Aims: Thyroid hormone (TH) signalling is critical for heart function. The expresses thyroid receptors (THRs); THRα1 and THRβ1. We aimed to investigate the regulation mechanisms of THRβ isoform, its association with gene expression changes implications cardiac Methods: experiments were performed using adult male mice expressing TRβΔ337T, which contains Δ337T mutation human THRB impairs ligand binding. Cardiac function RNA studied after hypo-or hyperthyroidism inductions. T3-induced...

The present study determined the effect of an electrolytic lesion dorsal raphe nucleus (DRN) on water intake and sodium appetite. Male Wistar rats weighing 290-320 g with a DRN (L-DRN), performed two days before experiments confirmed by histology at end experiments, presented increased sensitivity to dehydration induced fluid deprivation. cumulative L-DRN reached 23.3 ± 1.9 ml (a 79% increase, N = 9) while sham-lesioned (SL-DRN) did not exceed 13.0 1.0 (N 11, P < 0.0001) after 5 h. treated...

Objective. Considering the controversial data regarding role of brain renin-angiotensin system (RAS) on thirst and sodium appetite in ovariectomised rats, we aimed to evaluate angiotensin II (Ang II) AT1-receptor nocturnal fluids intake. Materials methods. Groups Wistar female rats were chronically given oestrogen or vehicle its influence effects induced by i.c.v. injection losartan,Ang I Ang II. Results. The losartan decreased basal water intake group.Ang but not I-induced dipsogenic...

In animal models the evaluation of myocardial infarct size in vivo and its relation to actual lesion found post mortem is still a challenge. The purpose current study was address if conventional electrocardiogram (ECG) and/or echocardiogram (ECHO) could be used adequately predict rats. Wistar rats were infarcted by left coronary ligation then ECG, ECHO histopathology performed at 1, 7 28 days after surgery. Correlation between histology Q wave amplitude lead L1 only when ECGs one day...

We determined if the dorsal raphe nucleus (DRN) exerts tonic control of basal and stimulated sodium water intake. Male Wistar rats weighing 300-350 g were microinjected with phosphate buffer (PB-DRN, N = 11) or 1 µg/0.2 µl, in a single dose, ibotenic acid (IBO-DRN, 9 to 10) through guide cannula into DRN observed for 21 days order measure appetite intake following situations: furosemide-induced depletion (20 mg/kg, sc, 24 h before experiment) low dose dietary captopril (1 mg/g chow). From...

We investigate the influence of brain serotonin depletion on sodium appetite. Rats depleted through systemic administration p-chlorophenylalanine (300 mg/kg, ip, for 2 days) showed an intense natriorexigenic response induced by (furosemide, 20 sc, 24 h before water and 1.8% NaCl presentation). Intake was always higher than that observed control group (12.9 ± 1.4 21.4 3.0 mL vs 5.7 1.2 12.7 1.6 mL, 30 300 min after saline After h, continued to be significantly compared (33.6±5.1 21.9±3.6 mL,P...

The role of serotonergic system in the feeding behaviorwas appraised by electrolytic lesions dorsal raphe nucleus (DRN) and administration para-chlorophenylalanine (PCPA, 3 mg/5 mul, icv). Chronic evaluations were accomplished through 120 360 days PCPA-injected DRN-lesioned rats, respectively. Acute food intake was evaluated fasted rats submitted to injection PCPA hydroxytryptophan (LHTP, 30 mg/kg, ip). exhibited 22-80% increase up sixth month, whereas obesity evident sustained whole period....