A5001985779- Genetic Mapping and Diversity in Plants and Animals
- Photosynthetic Processes and Mechanisms
- Genomics and Phylogenetic Studies
- Plant nutrient uptake and metabolism
- Wheat and Barley Genetics and Pathology
- Plant Molecular Biology Research
- Chromosomal and Genetic Variations
- SARS-CoV-2 and COVID-19 Research
- GABA and Rice Research
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Genetic diversity and population structure
- Herpesvirus Infections and Treatments
- Tryptophan and brain disorders
- Animal Virus Infections Studies
- Mycotoxins in Agriculture and Food
- Plant Disease Resistance and Genetics
- Genetic and phenotypic traits in livestock
- Pacific and Southeast Asian Studies
- Lipid metabolism and biosynthesis
- Fecal contamination and water quality
- Virus-based gene therapy research
- Environmental DNA in Biodiversity Studies
- Tracheal and airway disorders
- RNA and protein synthesis mechanisms
BASF (United States)
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Triangle
2025
National Clinical Research
2025
Shanxi Agricultural University
2025
Donald Danforth Plant Science Center
2014-2023
Sichuan Agricultural University
2013
Washington University in St. Louis
2011-2012
Asian rice, Oryza sativa, is one of world's oldest and most important crop species. Rice believed to have been domesticated ∼9,000 y ago, although debate on its origin remains contentious. A single-origin model suggests that two main subspecies indica japonica, were from the wild rice O. rufipogon. In contrast, multiple independent domestication proposes these major types separately in different parts species range rice. This latter view has gained much support observation strong genetic...
Abstract Wild and weedy relatives of domesticated crops harbor genetic variants that can advance agricultural biotechnology. Here we provide a genome resource for the wild plant green millet ( Setaria viridis ), model species studies C 4 grasses, use to probe domestication genes in close crop relative foxtail italica ). We produced platinum-quality assembly S. de novo assemblies 598 accessions exploited these identify loci underlying three traits: response climate, ‘loss shattering’ trait...
Abstract Gene functional descriptions offer a crucial line of evidence for candidate genes underlying trait variation. Conversely, plant responses to environmental cues represent important resources decipher gene function and subsequently provide molecular targets improvement through editing. However, biological roles large proportions across the phylogeny are poorly annotated. Here we describe Joint Genome Institute (JGI) Plant Atlas, an updateable data resource consisting transcript...
The emergence of a series SARS-CoV-2 variants has necessitated the search for broad-spectrum antiviral targets. aryl hydrocarbon receptor (AhR) senses tryptophan metabolites and is an immune regulator. However, role AhR in infection whether can be used as target therapy against its are yet unclear. Here, we show that with activates signaling facilitates viral replication by interfering IFN-I-driven immunity up-regulating ACE2 expression. pharmacological blockade or knockout reduces variants'...
Zymoseptoria tritici is a cosmopolitan hemibiotrophic wheat pathogen with high mutation rate and mixed reproduction system, sexual asexual cycles occurring within the same disease cycle. This leads to challenges in traditional farming management. For successful integrated pest management, especially for surveys of new aggressive lineages, it critical understand population diversity field. We look at whole-genome sequence data three datasets differentiate field fields similar size: one...
Asian wild rice (Oryza rufipogon) that ranges widely across the eastern and southern part of Asia is recognized as direct ancestor cultivated (O. sativa). Studies geographic structure O. rufipogon, based on chloroplast low-copy nuclear markers, reveal a possible phylogeographic signal subdivision in rufipogon. However, this differentiation not consistently observed among different markers studies, with often conflicting results. To more precisely characterize phylogeography rufipogon...
An extensive survey of the standing genetic variation in natural populations is among priority steps developing a species into model system. In recent years, green foxtail (Setaria viridis), along with its domesticated form millet (S. italica), has rapidly become promising new system for C4 grasses and bioenergy crops, due to rapid life cycle, large amount seed production small diploid genome, other characters. However, remarkably little known about diversity this species. study, we...
C4 photosynthesis is perhaps one of the best examples convergent adaptive evolution with over 25 independent origins in grasses (Poaceae) alone. The availability high quality grass genome sequences presents new opportunities to explore mechanisms underlying this complex trait using evolutionary biology-based approaches. In study, we performed genome-wide cross-species selection scans lineages facilitate discovery genes. study was enabled by well conserved collinearity genomes and recently...
Inflorescence architecture is a key determinant of yield potential in many crops and patterned by the organization developmental fate axillary meristems. In cereals, flowers grain are borne from spikelets, which differentiate final iteration meristem branching. Setaria spp, inflorescence branches terminate either spikelet or sterile bristle, these structures appear to be paired. this work, we leverage viridis investigate role for phytohormones brassinosteroids (BRs) specifying bristle...
Herpes simplex virus type 1 (HSV-1) is a ubiquitous human pathogen that can cause significant morbidity, primarily facial cold sores and herpes encephalitis. Previous studies have shown variety of viruses reprogram the metabolic profiles host cells to facilitate self-replication. In order further elucidate interactions between cell HSV-1, we used liquid chromatography-tandem mass spectrometry (LC-MS/MS) analyze in lung fibroblasts KMB17 infected with HSV-1. The results showed 654 474...
Zymoseptoria tritici is a cosmopolitan hemibiotrophic wheat pathogen with high mutation rate and mixed reproduction system, leading to challenges in traditional farming management. For successful integration of pest management, especially for early diagnostics new aggressive or fungicide-resistant lineages, it critical understand population diversity the field. We look at whole-genome sequence data three datasets differentiate within field fields similar size: one dataset from newly sampled...
<title>Abstract</title> A 43-year-old female patient with a history of left breast invasive carcinoma, treated mastectomy and adjuvant therapy, presented for delayed reconstruction after nearly three years stable disease. Following the mastectomy, experienced significant psychological distress due to absence her breast, severely impacting quality life. Routine follow-up examinations revealed no recurrence or metastasis. Preoperative assessments, including CT scans, 3D reconstruction,...
Genomic selection (GS) is a genetic breeding method that uses genome-wide marker information to improve the accuracy of prediction complex traits. The single-step GBLUP (ssGBLUP) model, which integrates pedigree, phenotypic, and genomic data, has improved prediction. However, ssGBLUP assumes all markers contribute equally variance, can limit its predictive accuracy, especially for traits controlled by major genes. To overcome this limitation, we integrate results from association studies...
In a recent study using two different methods of analysis and datasets, we concluded that domesticated Asian rice had single origin (1). Ge Sang (2) suggest our analyses were flawed the remains an open question.
Piwi-interacting RNAs (piRNAs) are a class of non-coding that play key role in spermatogenesis. However, little is known about their expression characterization and somatic cells infected with herpes simplex virus type 1 (HSV-1). In this study, we systematically investigated the cellular piRNA profiles HSV-1-infected human lung fibroblasts. Compared control group, 69 differentially expressed piRNAs were identified infection among which 52 up-regulated 17 down-regulated. The changes 8 further...
• Premise of the study: The combination traditional population genetic studies and species distribution modeling (SDM) provides many new insights in detecting phylogeographic signals. In Asian wild rice ( Oryza rufipogon ), progenitor cultivated rice, geographical subdivision has been documented although root cause this remains unknown. Surprisingly, environmental factors associated with spatial temporal O. have rarely examined. aim study is to understand historical its relationship current...
Abstract Diverse wild and weedy crop relatives hold genetic variants underlying key evolutionary innovations of crops under domestication. Here, we provide genome resources probe the basis domestication traits in green millet ( Setaria viridis ), a close relative foxtail S. italica ). Specifically, develop exploit platinum-quality assembly de novo assemblies for 598 accessions to identify loci a) response climate, b) ‘loss shattering’ trait that permits mechanical harvest, c) leaf angle,...
Abstract In C4 plants, the pyruvate (Pyr), phosphate dikinase regulatory protein (PDRP) regulates activity of pathway enzyme Pyr, (PPDK) in a light-/dark-dependent manner. The importance this action to function and overall photosynthesis is unknown. To resolve question, we assessed vivo PPDK phospho-regulation whole leaf photophysiology CRISPR–Cas9 PDRP knockout (KO) mutant NADP-ME grass green millet (Setaria viridis). was undetectable extracts from KO lines. Likewise, phosphorylated at...
ABSTRACT Gene functional descriptions, which are typically derived from sequence similarity to experimentally validated genes in a handful of model species, offer crucial line evidence when searching for candidate that underlie trait variation. Plant responses environmental cues, including gene expression regulatory variation, represent important resources understanding function and targets plant improvement through editing other biotechnologies. However, even after years effort numerous...
The possibilities of cross-species transmission SARS-CoV-2 variants concern (VOCs) between humans and poultry species are unknown. analysis the structure receptor was used to investigate potential emerging VOCs expand tropism chickens based on interaction Spike (S) protein tyrosine kinase UFO (AXL), angiotensin-converting enzyme 2 (ACE2), neuropilin 1 (NRP1) with substantial public health importance.The structural genetic alignment surface amino acid (aa) in ACE2, AXL, NRP1 human, hamster,...