A5101705870- Chromatography in Natural Products
- Analytical Chemistry and Chromatography
- Inhalation and Respiratory Drug Delivery
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Monoclonal and Polyclonal Antibodies Research
- Food Quality and Safety Studies
- Lung Cancer Treatments and Mutations
- Angiogenesis and VEGF in Cancer
- Glutathione Transferases and Polymorphisms
- Breast Cancer Treatment Studies
- Genomics, phytochemicals, and oxidative stress
- RNA modifications and cancer
- Carcinogens and Genotoxicity Assessment
- DNA Repair Mechanisms
- Dialysis and Renal Disease Management
- Microencapsulation and Drying Processes
- Click Chemistry and Applications
- Cancer Immunotherapy and Biomarkers
- Cancer Treatment and Pharmacology
- Medicinal Plant Pharmacodynamics Research
- Circular RNAs in diseases
First Affiliated Hospital of Xi'an Jiaotong University
2013-2025
Nanjing Drum Tower Hospital
2025
Taizhou People's Hospital
2025
Nanjing Medical University
2025
Nantong University
2025
First Affiliated Hospital Zhejiang University
2024
Western University
2022-2024
Pingliang People's Hospital
2024
Jilin University
2014-2024
China National Petroleum Corporation (China)
2024
Abstract Perinatal hypoxic‐ischemic encephalopathy (HIE) is a leading cause of neonatal death and neurological disability. Oxidative stress neuroinflammation are typical pathogenic factors HIE. Licochalcone A (LCA) exerts various biological properties, including anti‐inflammatory antioxidant activities. However, no data have been reported to elucidate the role LCA in development In present study, primary cultured rat cortical neurons were exposed oxygen‐glucose deprivation/reoxygenation...
Abstract Background and objective Single‐study evidence of separate combined effectiveness influenza pneumococcal vaccination in patients with chronic obstructive pulmonary disease (COPD) is limited. To fill this gap, we studied the trivalent seasonal vaccine (TIV) 23‐valent polysaccharide (PPSV23), separately together, at preventing adverse COPD outcomes. Methods Our study used a self‐controlled, before‐and‐after cohort design to assess TIV PPSV23 patients. Patients were recruited from...
Baicalin is an important active component of the medicinal herb Scutellaria baicalensis Georgi and has shown a variety pharmacological actions. The present study aimed to evaluate neuroprotective effects baicalin against diabetes‑associated cognitive deficits (DACD) in rats elucidate potential molecular mechanisms action. A rat model diabetes mellitus was prepared by intraperitoneal injection streptozotocin. After successful establishment diabetic model, (50, 100 200 mg/kg) or vehicle...
Acute lung injury (ALI) is caused by severe infection, and urgently needs effective treatments or validated pharmacological targets. Formyl peptide receptor 2 (Fpr2) plays essential roles in immune responses inflammatory diseases. In the present study, Fpr2 expression was markedly increased tissues of lipopolysaccharide (LPS)-challenged mice, these effects were confirmed LPS-stimulated macrophages. Then, vitro analysis suggested that knockdown significantly decreased LPS-induced response...
Objective To explore the risk factors for cardiotoxicity in patients with gastrointestinal (GI) tumors treated fluorouracil drugs. Methods This study included GI who received at our hospital between January 2018 and April 2022. The demographic clinical characteristics were collected. associated of explored using multivariable logistic regression. Results A total 300 finally divided into ( n = 81) non-cardiotoxicity groups 219). occurrence fluorouracil-induced was higher hypertension,...
Bladder cancer (BLCA) is one of the most common tumors urinary tract. The diagnosis BLCA mostly by invasive tests, which are damaging and unsuitable for early screening. Current non-invasive diagnostic modalities insufficient in sensitivity specificity. Therefore, novel markers urgently needed to facilitate detection bladder cancer. tRNA-derived small RNAs (tsRNAs) considered be potentially biologically functional non-coding (ncRNAs). tsRNAs have been used help a variety tumors. However,...
Abstract Purpose: Osteosarcoma represents the most common malignant primary bone tumor in childhood; however, survival rate has remained unchanged for past 20 years. To improve existing diagnosis and treatment methods broaden spectrum of imaging agents that can be used early detection assessment response to therapy, we performed a phage display–based screening peptide sequences bind specifically osteosarcoma cells. Experimental Design: From Ph.D.-12 display library composed 2.7 × 109...
Vascular endothelial growth factor (VEGF) is one of the most important mediators angiogenesis. Single-chain (sc)-VEGF protein containing an N-terminal Cys-tag has been designed for site-specific modification with a variety imaging and therapeutic moieties. Site-specific labeling scVEGF thiol-reactive prosthetic group, N-[2-(4-(18)F-fluorobenzamido) ethyl] maleimide ([(18)F]FBEM) positron emission tomography (PET) VEFGR may provide new tracer which great potential clinical...
ABSTRACT Background Lupus nephritis (LN), one of the common manifestations systemic lupus erythematosus, continues to be a principal cause morbidity and mortality. According 2024 Kidney Disease: Improving Global Outcomes guidelines, belimumab has been recommended as adjunct therapy for active LN. However, differences in its efficacy safety between refractory newly diagnosed LN are unknown. This study aimed evaluate them real-world clinical setting China. Methods We enrolled patients who...
Piwi-interacting RNAs (piRNAs) are a class of non-coding that play key role in spermatogenesis. However, little is known about their expression characterization and somatic cells infected with herpes simplex virus type 1 (HSV-1). In this study, we systematically investigated the cellular piRNA profiles HSV-1-infected human lung fibroblasts. Compared control group, 69 differentially expressed piRNAs were identified infection among which 52 up-regulated 17 down-regulated. The changes 8 further...