A5073461448- Cardiovascular Function and Risk Factors
- Neonatal Respiratory Health Research
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Neonatal and fetal brain pathology
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Cardiac Arrhythmias and Treatments
- Renal Diseases and Glomerulopathies
- Cardiomyopathy and Myosin Studies
- Cancer Cells and Metastasis
- Kruppel-like factors research
- Chronic Kidney Disease and Diabetes
- Anesthesia and Neurotoxicity Research
- 3D Printing in Biomedical Research
- Systemic Lupus Erythematosus Research
- Cytomegalovirus and herpesvirus research
- Mosquito-borne diseases and control
- Platelet Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Plant Molecular Biology Research
- Hippo pathway signaling and YAP/TAZ
- Phytoestrogen effects and research
- Cardiac electrophysiology and arrhythmias
- Advanced Nanomaterials in Catalysis
Peking University Shenzhen Hospital
2014-2025
Jinan University
2009-2024
First Affiliated Hospital of Wenzhou Medical University
2024
Southwest Research Institute
2024
Wenzhou Medical University
2024
University of California, San Diego
2017-2023
Beijing University of Technology
2022
Southwest Hospital
2022
Army Medical University
2015-2022
Third Affiliated Hospital of Zhengzhou University
2005-2022
The purpose of this study was to evaluate the efficacy and safety erythropoietin in neonatal hypoxic-ischemic encephalopathy (HIE), by using a randomized, prospective design.A total 167 term infants with moderate/severe HIE were assigned randomly receive either (N = 83) or conventional treatment 84). Recombinant human erythropoietin, at 300 U/kg 52) 500 31), administered every other day for 2 weeks, starting <48 hours after birth. primary outcome death disability. Neurodevelopmental outcomes...
Interleukin-37 (IL-37), a new member of IL-1 family cytokine, is recently identified as natural inhibitor innate immunity. This study aimed to measure the peripheral blood mononuclear cells (PBMCs) and serum levels IL-37 in patients with systemic lupus erythematosus (SLE) investigate its role SLE, including correlation disease activity, organ disorder regulation inflammatory cytokines. The expressions mRNAs PBMCs 66 SLE were measured by real-time polymerase chain reaction (RT-PCR)...
Background Cancer is a serious threat to the whole of humanity. The Multi-Cancer Early Detection (MCED) test expected solve problem “Universal cancer screening”. purpose this study evaluate MCED value two tests, YiDiXie™-HS and YiDiXie™-SS, in multiple types. Patients methods 11094 subjects were finally included (the malignant tumor group, n = 4405; normal control 6689). group all major solid hematological sensitivity specificity YiDiXie™-SS evaluated, respectively. Results overall for...
Colorectal cancer (CRC) ranks among the most prevalent malignant tumors globally. Recent reports suggest that
We investigated left atrial (LA) function in relation to hypertension using 2-dimensional speckle-tracking echocardiography (STE) subjects with preserved ventricular (LV) ejection fraction, while accounting for LA enlargement and LV mass diastolic function. performed standard Doppler volumetric measurements STE strain imaging hypertensive patients (systolic/diastolic blood pressure ≥140/90 mmHg, or use of antihypertensive drugs, n = 124) age- sex-matched normotensive (n 124). measured the...
Maintenance of high-turnover tissues such as the epidermis requires a balance between stem cell proliferation and differentiation. The molecular mechanisms governing this process are an area investigation. Here we show that HNRNPK, multifunctional protein, is necessary to prevent premature differentiation sustains proliferative capacity epidermal progenitor cells. To cells, HNRNPK for DDX6 bind subset mRNAs code transcription factors promote Upon binding, these GRHL3, KLF4, ZNF750 degraded...
Abstract Aim Strict criteria of typical left bundle branch block (LBBB) can help with the prediction for cardiac resynchronization therapy response. The aim this study is to determine whether use strict both LBBB and right (RBBB) predicts successful QRS correction (≤130 ms) by area pacing (LBBAP). Methods Consecutive patients pacemaker indications according present guideline who also underwent LBBAP implantation were retrospectively assessed. Inclusion BBB baseline QRSd > 130 ms. Baseline...
Several methods for generating human-skin-equivalent (HSE) organoid cultures are in use to study skin biology; however, few studies thoroughly characterize these systems. To fill this gap, we single-cell transcriptomics compare vitro HSEs, xenograft and vivo epidermis. By combining differential gene expression, pseudotime analyses, spatial localization, reconstruct HSE keratinocyte differentiation trajectories that recapitulate known epidermal pathways show HSEs contain major cellular...
Soil is recognized as an important source of atmospherically reactive gases, especially in agricultural soils. Nonetheless, there scarcity research estimating nitrogen gas (Nr) emissions from soils at the regional to global scale. In this study, we examined nitrous acid (HONO) and nitric oxide (NO) seven representative Guangdong Province, considering soil moisture temperature, using a dynamic chamber system. Accordingly, empirical formulas for HONO NO each relation temperature were...
Nitrous acid (HONO) is a key precursor of hydroxyl radicals (OH) in the urban atmospheric boundary layer. However, most HONO observations so far are on ground level, while chemistry at higher altitude remains largely unknown. Through one-month 450 m platform Canton Tower Guangzhou, China, we have identified two distinct regimes nocturnal chemistry. One dominated by heterogeneous reactions surface, likely corresponding to period when was within stable Another regime, occurring residual layer,...
3582 Background: Apomab, a fully human affinity-matured IgG1 monoclonal antibody, is DR5 pro-apoptotic receptor agonist that triggers the extrinsic pathway of apoptosis. expressed both on malignant and normal cells; however, pre-clinical data indicate activation stimulates apoptosis predominantly in cells. This first-in-human study assessed safety, pharmacokinetics (PK) any early evidence anti-cancer efficacy Apomab. Methods: Patients with advanced treatment-refractory solid tumors received...
To evaluate the efficacy of systemic hypothermia when applied within 10 hours after birth to neonates with hypoxic-ischemic encephalopathy (HIE).Ninety-three term infants moderate-to-severe HIE were randomly assigned either (n = 46) or conventional treatment 47). Hypothermia was induced birth, decreasing rectal temperature 33.5°C for 72 hours, followed by slow rewarming 36.5°C. Neurodevelopmental outcome assessed at 18 months old. The primary death disability.Outcome data available 82...
Impairments in the differentiation process can lead to skin diseases that afflict ∼20% of population. Thus, it is utmost importance understand factors promote process. Here we identify transcription factor KLF3 as a regulator epidermal differentiation. Knockdown results reduced gene expression and increased cell cycle expression. Over half KLF3's genomic binding sites occur at active enhancers. binds enhancers proximal genes are dependent upon for also highly overlaps with CBP, histone...
Adult stem and progenitor cells are critical for replenishing lost tissue due to injury or normal turnover. How these maintain self-renewal sustain the they populate areas of active investigation. Here, we show that cohesin complex, which has previously been implicated in regulating chromosome segregation gene expression, is necessary promote epidermal cell through cell-autonomous mechanisms. Cohesin binds genomic sites associated with open chromatin, including DNase-I-hypersensitive sites,...
Diabetic nephropathy (DN) is a serious complication of diabetes with poorly defined etiology and limited treatment options. Early intervention key to preventing the progression DN. Dynamin-related protein 1 (DRP1) regulates mitochondrial morphology by promoting its fission involved in pathogenesis numerous diseases. Furthermore, DRP1 also closely associated development diabetes, but functional role DN remains unknown. This study investigated effect on early stage expression has increased...
Decreased Core I β3-Gal-T-specific molecular chaperone (Cosmc) expression induced IgA1 aberrant glycosylation is the main characteristic of IgA nephropathy (IgAN). This study tried to elucidate effect Astragalus membranaceus on Cosmc and O-glycosylation peripheral B lymphocytes in IgAN patients.Peripheral 21 patients 10 normal controls were isolated cultured with or without lipopolysaccharide (LPS) injection (AMI). mRNA protein levels measured by real-time RT-PCR Western blot. level...