A5103133408- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- Intraocular Surgery and Lenses
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Optical measurement and interference techniques
- Hematopoietic Stem Cell Transplantation
- Dermatologic Treatments and Research
- Platelet Disorders and Treatments
- Ocular Infections and Treatments
- melanin and skin pigmentation
- Streptococcal Infections and Treatments
- CAR-T cell therapy research
- Phytochemical and Pharmacological Studies
- Autophagy in Disease and Therapy
- Soft tissue tumors and treatment
- Blood groups and transfusion
- Plant pathogens and resistance mechanisms
- Periodontal Regeneration and Treatments
- IgG4-Related and Inflammatory Diseases
- Glycosylation and Glycoproteins Research
- Neuroendocrine Tumor Research Advances
- Acute Myeloid Leukemia Research
- Histiocytic Disorders and Treatments
- Visual perception and processing mechanisms
Nanchang Hangkong University
2011-2025
Koo Foundation Sun Yat-Sen Cancer Center
2009-2024
Longgang Central Hospital
2024
Shenzhen Institutes of Advanced Technology
2017-2020
Zhejiang University
2015-2017
Chinese Academy of Sciences
2017
Tianjin Medical University Eye Hospital
2013
Tianjin Medical University
2013
Nankai University
2009-2010
Huzhou Central Hospital
2007-2008
Emerging evidence suggests that the gut microbiome actively regulates cognitive functions and imbalance is associated with Alzheimer’s disease (AD), most prevalent neurodegenerative disorder. However, changes in composition AD their association pathology, especially early stages, are unclear. Here, we compared profiles of microbiota between APP/PS1 transgenic mice (an mouse model) wild-type littermates at different ages by amplicon-based sequencing 16S ribosomal RNA genes. Microbiota started...
Although chimeric antigen receptor T-cell (CAR-T) therapy development for B-cell malignancies has made significant progress in the last decade, broadening success to treating acute lymphoblastic leukemia (T-ALL) been limited. We conducted two clinical trials verify safety and efficacy of GC027, an "off-the-shelf" allogeneic CAR-T product targeting antigen, CD7. Here, we report 2 patients as case reports with relapsed/refractory T-ALL who were treated GC027.Both reported here open-label...
To investigate the effect of percent tissue altered (PTA) on safety after laser-assisted in situ keratomileusis (LASIK) based linear creep characteristics. The characteristics cornea were characterized by generalized Kelvin-Voigt constitutive relationship with five parameters. Then, displacement and stress distribution anterior posterior surfaces analyzed constructing eye model different PTA. When PTA was above 39%, vertex displacements under physiological intraocular pressure (IOP, 15 mm...
Abstract Background It is well known that the biomechanical properties change after LASIK refractive surgery. One reason impact of flap creation on residual stroma. The results have revealed closely related with thickness in several studies. However, quantitative relationships between distributions displacement and stress corneal surface not been studied. aim study was to quantify evaluate caused by flap. Methods By building a finite element model cornea, displacement, strain were analyzed....
To examine the biomechanical effects-induced wave-front aberrations after conventional laser refractive surgery.A finite element model of human eye was established to simulate surgery with corrected refraction from -1 -15 diopters (D). The deformation anterior and posterior corneal surfaces obtained under intraocular pressure (IOP). Then, surface displacement converted aberrations.Following surgery, significant occurred because effects, resulting in increased residual aberrations....
To analyze the induced wavefront aberrations caused by treatment decentration and transition zone after custom myopic laser refractive surgery.Refractive Surgery Center, Tianjin Eye Hospital & Institute, Medical University, Tianjin, China.Cohort study.Wavefront aberration data from potential surgery candidates were used. Based on preoperative aberrations, ablation profile was computed. Then, influence of especially that studied. The impact angle mismatch analyzed.Data 117 eyes (77 patients)...
Analysis of induced wavefront aberration after refractive surgery is important in the design vision correction and development visual technology. Based on a mathematical model anterior corneal surface, influence treatment decentration aberrations was studied by considering oblique incidence. The results revealed that significant coma from translation, it nearly proportional to translation or corrected refraction correction. lateral correlated with angle formed position vector astigmatism...
The analysis of the change in residual wavefront aberrations after laser refractive surgery is important for development visual correction technology. Based on ablation profile wavefront-guided including optical zone and transition zone, effect pupil size was studied. research revealed that to ratio had a significant influence aberrations. spherical aberration coma were obviously larger than other individual Zernike higher-order terms when diameter size, they increased rapidly as increased....
Streptococcus suis is regarded as one of the major pathogens pigs, and type 2 (SS2) considered a zoonotic bacterium based on its ability to cause meningitis streptococcal toxic shock-like syndrome in humans. Many bacterial species contain genes encoding serine/threonine protein phosphatases (STPs) responsible for dephosphorylation their substrates single reaction step. This study investigated role stp1 pathogenesis SS2. An isogenic mutant (Δstp1) was constructed from SS2 strain ZJ081101. The...
(1) Background: Busulfan has been used as a conditioning regimen in allogeneic hematopoietic cell stem transplantation (HSCT). Owing to large inter-individual variation pharmacokinetics, therapeutic drug monitoring (TDM)-guided busulfan dosing is necessary reduce graft failure and relapse rate. As there exists no TDM of administration for HCT Taiwan, we conducted pilot study assess the TDM-dosing Taiwanese population; (2) Methods: Seven patients with from The Koo Foundation Sun Yat-Sen...
Rationale: Sjögren syndrome (SS) is a prevalent autoimmune disorder targeting exocrine glands, causing symptoms such as dry eyes and mouth. It often goes underdiagnosed due to its varied presentations, emphasizing the importance of early accurate diagnosis. Patient concerns: A 22-year-old female presented with atypical hypokalemic paralysis severe bone pain, which are not commonly associated SS. Diagnoses: Extensive diagnostic workup, including serological tests, ophthalmological...
Purpose: This study analyzed the biomechanical responses of different corneal cap thicknesses after small incision lenticule extraction (SMILE). Methods: Individual finite element models myopic eyes were constructed based on clinical data. Then, four types SMILE included for each model. The effects material parameters and intraocular pressure corneas with analyzed. Results: When thickness increased, vertex displacements anterior posterior surfaces decreased slightly. stress distributions...
We evaluated the impact of Stiles–Crawford effect (SCE) on visual performance following laser in situ keratomileusis procedures. This prospective study included 71 eyes 36 consecutive myopic patients (mean age, 20.94±3.69 years). Ocular aberrations and contrast sensitivity were measured one month after surgery. The SCE was modeled optically as a filter placed front eye, then modulation transfer functions (MTFs) predicted log calculated from wavefront aberration data. Then Strehl ratio for...
To evaluate optical quality in white light for a myopic population by means of some metrics, such as AreaMTF, VSMTF and EE.One hundred thirteen eyes 113 subjects were enrolled this study. The metrics computed from the polychromatic PSF, which was calculated super-position monochromatic PSFs each wavelength.The relationship between root mean square (RMS) higher-order aberrations shows that values EE tend to decrease gradually with increase RMS. When RMS maintains constant value, varies...
<abstract> <sec><title>Purpose</title> To investigate the biomechanical responses of human cornea after small incision lenticule extraction (SMILE) procedures, especially their effects SMILE surgery on stress and strain. </sec> <sec><title>Methods</title> Based finite element analysis, a three-dimensional (3D) model eye was established to simulate refractive procedures. Stress strain values were calculated by inputting intraocular pressure (IOP). <sec><title>Results</title> After anterior...
Autologous cord blood transplantations are rarely applied in patients with hematologic as well metastatic solid cancers since contamination of malignant clones is a concern. We report case therapy-related myelodysplasia after neuroblastoma who suffered from graft rejection and life-threatening infections myeloablative unrelated transplantation. The patient experiences long-term survival, free leukemia/neuroblastoma infusion autologous cells. It suggests that transplantation high dose therapy...