A5080877438- Multiple Myeloma Research and Treatments
- Parasites and Host Interactions
- Protein Degradation and Inhibitors
- Child Nutrition and Water Access
- Parasite Biology and Host Interactions
- Helminth infection and control
- Iron Metabolism and Disorders
- Global Maternal and Child Health
- Cancer Treatment and Pharmacology
- Viral gastroenteritis research and epidemiology
- Zoonotic diseases and public health
- Peptidase Inhibition and Analysis
- Histone Deacetylase Inhibitors Research
- Chronic Lymphocytic Leukemia Research
- Spinal Cord Injury Research
- Organic Food and Agriculture
- Nerve Injury and Rehabilitation
- Bone health and treatments
- Cancer Mechanisms and Therapy
- Hemoglobinopathies and Related Disorders
- Immunotherapy and Immune Responses
- Thyroid Cancer Diagnosis and Treatment
- Agriculture and Rural Development Research
- Parasitic Infections and Diagnostics
- Respiratory viral infections research
University of Leeds
2015-2024
Cancer Research UK
2024
Cancer Research UK Clinical Trials Unit
2023
University of Westminster
2004-2013
Helen Keller International
2002
Centre for Human Genetics
1998-2001
University of Oxford
1994-2001
Dhaka International University
2001
International Centre for Diarrhoeal Disease Research
1991-1999
MRC Epidemiology Unit
1995
The multicenter OPTIMUM (MUKnine) phase II trial investigated daratumumab, low-dose cyclophosphamide, lenalidomide, bortezomib, and dexamethasone (Dara-CVRd) before after autologous stem-cell transplant (ASCT) in newly diagnosed patients with molecularly defined ultra-high-risk (UHiR) multiple myeloma (NDMM) or plasma cell leukemia (PCL). To provide clinical context, progression-free survival (PFS) overall (OS) were referenced to contemporaneous outcomes seen UHiR NDMM treated the recent...
The comparative efficacy of albendazole and mebendazole in the treatment intestinal nematode infections were compared 3 weeks after a randomized trial among schoolchildren on Pemba Island, Tanzania. Egg counts weeks, 4 months 6 731 children seen each occasion. Differences efficacies apparent with some nematodes 21 d treatment, but these no longer by intensities infection similar to pre-treatment levels. These findings suggest that every may be necessary this highly endemic area order have an...
Journal Article A randomized controlled trial comparing mebendazole and albendazole against Ascaris, Trichuris hookworm infections Get access Marco Albonico, Albonico 1Programme of Intestinal Parasitic Infections, Division Communicable Diseases, World Health Organization, Geneva, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar Peter G. Smith, Smith 2Department Epidemiology Population Sciences, London School Hygiene Tropical Medicine, London, UK...
Abstract Objective To report on the haemoglobin concentrations and prevalence of anaemia in schoolchildren eight countries Africa Asia. Design Blood samples were collected during surveys health as a part programmes to develop school-based services. Setting Rural schools Ghana, Indonesia, Kenya, Malawi, Mali, Mozambique, Tanzania Vietnam. Subjects Nearly 14 000 children enrolled basic education three age ranges (7–11 years, 12–14 years Ä15 years) which reflect new...
As part of an investigation intestinal parasitic infections rural Kenyan people, a study was undertaken to examine variation in faecal egg counts and assess the sensitivity ether sedimentation technique processing diagnosis helminth infections. Three samples day were collected for five consecutive days from 10 men known harbour total 23 nematode Ascaris lumbricoides, Trichuris trichiura hookworm. Considerable encountered among same stool, as well over period. Some possible causes this are...
In this paper, remotely sensed (RS) satellite sensor environmental data, using logistic regression, are used to develop prediction maps of the probability having infection prevalence exceeding 50%, and warranting mass treatment according World Health Organization (WHO) guidelines. The model was developed data from one area coastal Tanzania validated with independent different areas country. Receiver operating characteristic (ROC) analysis evaluate model’s predictive performance. allows...
Baseline epidemiological data are presented from a parasitological survey conducted in Thuy Loi commune, Ha Nam province, Vietnam; farming community where night soil is routinely used as fertilizer for crops. 177 households were visited and 543 individuals (aged 1–88 years) recruited to the study. Helminth infection intensity was assessed by Kato‐Katz determine density of parasite eggs per gram stool (epg). Ascaris lumbricoides, Trichuris trichiura hookworm infections only species detected....
Background. Diarrhea is an important public health concern in developing countries such as Bangladesh. children that persists for 14 days or more occurs 7% of patients Bangladesh and frequently results death. Astrovirus has been demonstrated a cause acute nosocomial diarrhea can be excreted prolonged periods, yet its importance among country like not investigated. Methods. We tested 629 stool specimens from with diarrhea, 153 persistent 175 76 hospitalized who were sampled repeatedly to...
Objective To estimate the prevalence of World Health Organization-defined chronic suppurative otitis media (CSOM) and mild hearing impairment in a population representative sample school-entry age children rural Malawi. A secondary objective was to explore factors associated with CSOM this population. Methods We performed community-based cross-sectional study aged 4–6 years Chikhwawa District, Southern Malawi, utilising village-level cluster design. Participants underwent structured clinical...
Thyroid cancer is the most common endocrine malignancy. Some advanced disease is, or becomes, resistant to radioactive iodine therapy (refractory disease); this holds poor prognosis of 10% 10-year overall survival. Whilst Sorafenib and Lenvatinib are now licenced for treatment progressive refractory thyroid cancer, these treatments require continuing can be associated with significant toxicity. Evidence from a pilot study has demonstrated feasibility Selumetinib allow reintroduction I-131...
Of the 39 most common helminth parasites of man listed by Peters & Gilles (1977), 30 may be detected and often diagnosed finding their eggs or larvae in faeces infected people. The preferred habitat many these helminths is alimentary tract itself continual flow material through food tube provides a simple, passive reliable means transport eventual exit from host for reproductive stages worm. Helminth are generally less than 150 μm diameter although individually comprise small investment...
Ascaris lumbricoides exhibits density-dependent egg production, a process which has marked impact on both the transmission dynamics and stability of parasite population. Evidence suggests that production female is also associated with size worm. If worm mediated by processes then worms may have causal upon patterns production. We analyse data collected from cohort human hosts, demonstrate per host mean weight (a proxy for size) dependent number infecting females (worm burden) following...
Introduction Multiple myeloma (MM) is a plasma cell tumour with over 5800 new cases each year in the UK. The introduction of biological therapies has improved outcomes for majority patients MM, but approximately 20% characterised by genetic changes which confer significantly poorer prognosis, generally termed high-risk (HR) MM. It important to diagnose these early and identify more effective first-line treatment options patients. Methods analysis Myeloma UK nine OPTIMUM trial (MUK )...
Summary We evaluated the effect of weekly doses 400 mg ferrous sulphate for 4 months on iron status adolescent girls in a controlled trial Tanga, Tanzania. Supplementation led to significantly greater increase serum ferritin compared with control group (+ 15.6 μg/l vs . 8.6 μg/l) ( P = 0.002) but there was no significant difference change haemoglobin. Children given showed weight gain than controls 2.4 kg + 1.4 kg) 0.03). Weekly supplementation may be an effective means increasing stores and...
Journal Article Albendazole and infections with Ascaris lumbricoides Trichuris trichiura in children Bangladesh Get access Andrew Hall, Hall ∗ International Centre for Diarrhoeal Disease Research, Bangladesh, P.O. Box 128, Dhaka 1000, ∗Current address correspondence: Department of Biology, Imperial College, Prince Consort Road, London, SW7 2BB, UK. Search other works by this author on: Oxford Academic PubMed Google Scholar Quamrun Nahar Transactions The Royal Society Tropical Medicine...
Treatment options for patients with thyroid cancer that is no longer sensitive to iodine therapy are limited. Those treatments which currently exist associated significant toxicity. The SELIMETRY trial (EudraCT No 2015-002269-47) aims investigate the role of MEK inhibitor Selumetinib in resensitizing advanced refractory differentiated radioiodine therapy. Patients deemed have sufficient uptake previously lesions after 4 weeks will be given an empirical activity 5.5 GBq I-131, and response...
Abstract Objective: To assess the effect on haemoglobin concentrations of schoolchildren weekly iron tablets administered by teachers. Design: Sixty schools were randomly assigned to two groups: in 30 children given for 10 weeks a tablet providing 65 mg and 0.25 folic acid; other no given. All dewormed vitamin A before study began. The concentration up 20 selected each school was estimated 2 after end treatment. Setting: Rural community Kolondieba district Mali. Subjects: Some 1113 aged 6–19...
Antibody titers to six pneumococcal polysaccharides were measured by enzyme-linked immunosorbent assay in Gambian children before and 1 month after vaccination with a 23-valent capsular polysaccharide vaccine at the ages of 2, 4, 6 or 9 months 5 10 years age. IgG responses type 1, 3 seen all age groups. Responses 19F 23F only oldest children. Few any responded immunization 6A polysaccharide. The immune response infants components polyvalent was comparable that described previously Finnish...
The prevalence of Taenia saginata (Cestoda) among 146 predominantly Pokot tribesmen in western Kenya was studied an attempt to assess the reliability detecting infections by faecal examinations. firstly, a single sample microscopically examined after being processed standard ether sedimentation technique. Secondly, all subjects were treated with niclosamide and purgative tapeworms recovered. In this way efficiency diagnosing examinations estimated. T. eggs found faeces 68% men who eventually...
The Ascaris lumbricoides expelled by 1765 people in a poor urban community Bangladesh were recovered and counted after the subjects had been treated with pyrantel pamoate. divided into 22 classes age sex (mean n = 80) to examine how prevalence, mean worm burdens measures of aggregation worms varied between sexes, see measure aggregation, k, calculated 3 ways (by maximum likelihood, from moments, or percentage uninfected) compared an empirical index (the who arbitrary 80% all worms)...