A5100669704- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Air Quality and Health Impacts
- Neonatal Respiratory Health Research
- Occupational and environmental lung diseases
- Lipid Membrane Structure and Behavior
- Bladder and Urothelial Cancer Treatments
- Antimicrobial Peptides and Activities
- Immunotherapy and Immune Responses
- Occupational exposure and asthma
- Immune Response and Inflammation
- Diverse Approaches in Healthcare and Education Studies
- Inhalation and Respiratory Drug Delivery
- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- Infant Development and Preterm Care
- Renal and Vascular Pathologies
- IL-33, ST2, and ILC Pathways
- Monoclonal and Polyclonal Antibodies Research
- Biochemical and Molecular Research
- Biochemical and Structural Characterization
- Education, Safety, and Science Studies
- Shoulder Injury and Treatment
- Cystic Fibrosis Research Advances
- Antimicrobial Resistance in Staphylococcus
Chosun University
2023
Merck & Co., Inc., Rahway, NJ, USA (United States)
2015-2022
Pusan National University
2017-2018
Pusan National University Yangsan Hospital
2016
Severance Hospital
2015
Yonsei University
2015
Gachon University
2014
Handong Global University
2012
Hallym University
2009
University of Missouri Hospital
2007
Cordyceps militaris, known as Dong-Chong-Xia-Cao, produces the most cordycepin among species and can be cultured artificially. For these reasons, C. militaris is widely used herb or functional food in East Asia. In this study, we developed a new strain of that higher content than parent strains through mating-based sexual reproduction. Twenty were collected identified based on internal trasncrived spacer rDNA sequences. Seven single spores MAT 1-1 idiomorph five 1-2 isolated from 12 strains....
Background: There are no known studies that have investigated the effect on delaminated rotator cuff tears of bursal layer–only repair when full-thickness would put articular layer under tension, compared with all-layers is feasible. Hypothesis: Better outcomes will be seen in repair, as tension repaired onto its footprint during repair. Study Design: Cohort study; Level evidence 3. Methods: This study included 112 patients who underwent arthroscopic for posteriorly either all layers (group...
Asbestos exposure causes asbestos-related diseases (ARDs) including asbestosis, malignant mesothelioma, lung cancer, laryngeal and ovarian cancer. Although Korea used substantial amounts of asbestos in the past, no study has focused on its occupational burden disease (OBD). Therefore, this aimed to determine OBDs ARDs Korea. The CARcinogen Exposure (CAREX) database was proportion exposed population. Relative risks for cancer were population-attributable fraction. Data deaths caused by during...
The goal of this study is to develop a general population job-exposure matrix (GPJEM) on asbestos estimate occupational exposure levels in the Republic Korea.Three Korean domestic quantitative datasets collected from 1984 2008 were used build GPJEM. Exposure groups data reclassified based current Standard Industrial Classification (9th edition) and Occupations code (6th that accordance international standards. All expressed by weighted arithmetic mean (WAM) minimum maximum...
Because of the long asbestos-related disease latencies (10-50 years), detection, diagnosis, and epidemiologic studies require asbestos exposure history. However, environmental source (EAES) data are lacking.To survey available for past EAES supplement these with interviews.We constructed an database using a literature review interviews experts, former traders, workers. Exposure sources by time period type were visualized geographic information system (ArcGIS), web-based mapping (Google...
In 2009, Korea banned the import, transport, and use of asbestos, Asbestos Injury Relief Act (AIRA) was promulgated in 2011.Two environmental health centers for asbestos (EHCA), including Pusan National University Yangsan Hospital (PNUYH) SoonChunHyang Cheonan (SCHUCH), were adapted to find asbestos-related diseases (ARDs) support purposes AIRA.EHCA conducted a impact survey (HIS) on persons who resided or reside near factories mines.A total 13,433 have taken screening examinations PNUYH...
Recently high-rise housing has become prosperous in Korea as a type of multi-use building, having good conditions traffic, site exiting, facilities etc. In terms residential environment, not always provided ideal conditions. Lack research about resident's attitudes towards led to dubious presumptions. this paper, I would like define the characteristics and investigate presumptions made regarding residents' attitudes. The data for definition psychological were collected using survey...
Abstract Amphipathic α-helical peptides (AHPs) have shown potential as a therapeutic approach against multi-drug-resistant bacterial infections due to their broad-spectrum antimicrobial activity by disrupting membranes. However, nonspecific interactions with membranes often result in cytotoxicity toward mammalian cells. Previous studies that PxxP motif near the middle of cathelicidin-derived contributes potent and selective antibacterial activity. In this study, we compared KL18 KL-PxxP...
The approvals of idelalisib and duvelisib have validated PI3Kδ inhibitors for the treatment hematological malignancies driven by PI3K/AKT pathway. Our program led to identification structurally distinct heterocycloalkyl purine with excellent isoform kinome selectivity; however, they had high projected human doses. Improved ligand contacts gave potency enhancements, while replacement metabolic liabilities extended half-lives in preclinical species, affording low once-daily predicted Treatment...
Background: A highly potent pan-Janus kinase (JAK) inhibitor with excellent kinome selectivity was developed for topical delivery to treat severe asthma. This poorly soluble drug discovery candidate, iJAK-001, is expected exhibit long duration of JAK/STAT pathway inhibition at low doses in asthmatics because depot effect after dry powder inhalation. Human dose projection inhaled molecules aqueous solubility remains be a daunting challenge several limitations: (1) bioanalytical measurement...
The 15-meric S-tag is a truncated form of the S-peptide, which builds together with 103 amino acid large S-protein whole ribonuclease S-protein. Its small size and excessive solubility have made an excellent fusion partner in production recombinant proteins, variety applications been reported using as carrier. While S-tagged proteins were mostly detected analyzed so far by use their affinity to S-proteins, monoclonal antibodies (MAbs) for this tag not available. generation specific expected...
Abstract Antimicrobial peptides (AMPs) are a crucial component of the natural defense system that host employs to protect itself against invading pathogens. PMAP-23, cathelicidin-derived AMP, has potent and broad spectrum antimicrobial activity. Our earlier studies led us hypothesize PMAP-23 adopts dynamic helix-hinge-helix structure, initially attaching membrane surfaces through N-helix subsequently inserting C-helix into lipid bilayer. Here, we rationally designed PMAP-NC with increased...
Asthmatics are more susceptible to viral infections than healthy individuals and known have impaired innate anti-viral defences. Influenza A virus causes significant morbidity mortality in this population. Immuno-modulatory regulators (IMRs) such as PD-1 activated on T cells following infection part of normal cell activation responses, then subside, but remain elevated cases chronic exposure virus, indicative exhaustion rather activation. There is evidence that checkpoint inhibition can...
Purpose: The survival rate of very low birth weight infant (VLBWI) had increased as a result advances in neonatal intensive care. We evaluated the changes outcomes VLBWI who admitted to care unit Hallym University Kangnam Sacred Heart Hospital. Methods: Retrospective review 339 were born from 1st January 1997 31th December 2008 performed. Outcomes including rate, (BW), gestational age (GA), morbidities, and mortality between period I (19972003) II (2004-2008) compared. Results: Overall...
The world’s population is quickly aging due to the increase in life expectancy and decline birth rate. In order solve various social problems caused by a deep understanding of needed. Research on currently active however there hasn’t been much work predicting using machine learning. This study proposes learning algorithm that uses body odor compounds related predicts aging. data was collected from 120 women 20s 70s with participants’ age sweat. After preprocessing, Supervised Learning, we...
<p>Supplementary Text S1. Comparison of other signatures with the three-gene signature</p>
<p>Supplementary Methods S1-S2. Supplementary S1. Analysis of Microarray gene expression profiling. S2. Primer sequences for RT-PCR, real-time PCR and chromatin immunoprecipitation (ChIP) assay.</p>