A5071164753- Traumatic Brain Injury and Neurovascular Disturbances
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Spinal Cord Injury Research
- S100 Proteins and Annexins
- Intracranial Aneurysms: Treatment and Complications
- Nerve Injury and Rehabilitation
- Clusterin in disease pathology
- Mesenchymal stem cell research
- Meningioma and schwannoma management
- Neurosurgical Procedures and Complications
- Glioma Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury Research
- Medicinal Plants and Bioactive Compounds
- Pluripotent Stem Cells Research
- Vascular Malformations Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Head and Neck Surgical Oncology
- Diabetes Treatment and Management
- Neonatal and fetal brain pathology
- Acute Ischemic Stroke Management
- Neuroscience and Neuropharmacology Research
Florida College
2024-2025
University of Florida
2024-2025
Karolinska Institutet
2016-2025
Center for Drug Evaluation and Research
2024-2025
Karolinska University Hospital
2014-2024
Witten/Herdecke University
2021
Oslo University Hospital
2005
University of Oslo
2005
Frederiksberg Hospital
2003
In-Q-Tel
1997
Brain-enriched protein biomarkers of tissue fate are being introduced clinically to aid in traumatic brain injury (TBI) management. The aim this study was determine how concentrations six different biomarkers, measured samples collected during the first weeks after TBI, relate severity and outcome. We included neurocritical care TBI patients that were prospectively enrolled from 2007 2013, all having one three blood drawn 2 weeks. analyzed S100 calcium-binding B (S100B), neuron-specific...
Leptomeninges, consisting of the pia mater and arachnoid, form a connective tissue investment barrier enclosure brain. The exact nature leptomeningeal cells has long been debated. In this study, we identify five molecularly distinct fibroblast-like transcriptomes in cerebral leptomeninges; link them to anatomically cell types pia, inner outer arachnoid barrier, dural border layer; contrast sixth transcriptome present choroid plexus median eminence. Newly identified transcriptional markers...
Abstract INTRODUCTION Whether reductions in glycated hemoglobin (HbA1c) levels and body mass index (BMI) mediate the association between glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) Alzheimer's disease related dementias (ADRD) risk is unknown. METHODS This cohort study included 22,908 patients aged ≥ 50 years with type 2 diabetes (T2D) newly prescribed GLP‐1RA or other second‐line glucose‐lowering drugs (GLDs). Causal mediation analysis was used to estimate what extent effect of...
The complement cascade has been suggested to be involved in the development of secondary brain injuries following contusions, based on animal experiments. aim present study was examine possible involvement traumatic head injury human brain. Sixteen patients were included this study, 12-77 years age, treated at neurointensive care unit for contusions. All these operated with frontal or temporal lobe resection due intractable intracranial hypertension. resected tissue analyzed regard...
Blood vessels and adjacent cells form perivascular stem cell niches in adult tissues. In this niche, a with mesenchymal characteristics was recently identified some somatic These are pericytes that line the microvasculature, express markers differentiate into mesodermal lineages but might even have capacity to generate tissue-specific types. Here, we isolated, purified characterized previously unrecognized progenitor population from two different regions human brain, ventricular wall...
In order to improve assessment and outcome prediction in patients suffering from traumatic brain injury (TBI), cerebral protein levels serum have been suggested as biomarkers of injury. However, despite much investigation, yet reach broad clinical utility TBI. This study is a 9-year follow-up experience the two most studied proteins, neuron-specific enolase (NSE) S100B, neuro-intensive care TBI population. Our aims were investigate what extent NSE independently combination, could predict...
BACKGROUND. Recombinant human PDGF-BB (rhPDGF-BB) reduces Parkinsonian symptoms and increases dopamine transporter (DAT) binding in several animal models of Parkinson's disease (PD). Effects rhPDGF-BB are the result proliferation ventricular wall progenitor cells reversed by blocking mitosis. Based on these restorative effects, we assessed safety tolerability intracerebroventricular (i.c.v.) administration individuals with PD. METHODS. We conducted a double-blind, randomized,...
Traumatic brain injury (TBI) is a major contributor to morbidity and mortality. Computerized tomography (CT) scanning of the essential for diagnostic screening intracranial injuries in need neurosurgical intervention, but may also provide information concerning patient prognosis enable baseline risk stratification clinical trials. Novel CT scoring systems have been developed improve current prognostic models, including Stockholm Helsinki scores, so far not extensively validated. The primary...
Abstract INTRODUCTION Sodium‐glucose cotransporter 2 (SGLT2) inhibitors exhibit potential benefits in reducing dementia risk, yet the optimal beneficiary subgroups remain uncertain. METHODS Individuals with type diabetes (T2D) initiating either SGLT2 inhibitor or sulfonylurea were identified from OneFlorida+ Clinical Research Network (2016–2022). A doubly robust learning was deployed to estimate risk difference (RD) and 95% confidence interval (CI) of all‐cause dementia. RESULTS Among 35,458...
Complement activation has been suggested to play a role in the development of secondary injuries following traumatic brain injury (TBI). The present study was initiated order analyze complement relation primary and insults, frequently occurring TBI.
Brain protein biomarker clearance to blood in traumatic brain injury (TBI) is not fully understood. The aim of this study was analyze the effect that a disrupted blood–brain barrier (BBB) had on clearance. Seventeen severe TBI patients admitted Karolinska University Hospital were prospectively included. Cerebrospinal fluid (CSF) and concentrations S100 calcium binding B (S100B) neuron-specific enolase (NSE) analyzed every 6–12 h for ∼1 week. Blood CSF albumin 12–24 h, BBB integrity assessed...
Microglia are resident myeloid cells of the CNS. Recently, single-cell RNA sequencing (scRNAseq) has enabled description a disease-associated microglia (DAM) with role in neurodegeneration and demyelination. In this study, we use scRNAseq to investigate temporal dynamics immune harvested from epicenter traumatic spinal cord injury (SCI) induced female mice. We find that as consequence SCI, baseline undergo permanent transcriptional reprogramming into previously uncharacterized subtype...
Severe traumatic brain injury (TBI) is associated with blood-brain barrier (BBB) disruption and a subsequent neuroinflammatory process. We aimed to perform multiplex screening of enriched inflammatory proteins in blood cerebrospinal fluid (CSF) order study their role BBB disruption, neuroinflammation long-term functional outcome TBI patients healthy controls.
Abstract Background Previous studies have suggested that glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) may a disease‐modifying effect in the development of Parkinson's disease (PD), but population yielded inconsistent results. Objective The aim was to compare risk PD associated with GLP‐1RAs compared dipeptidyl peptidase 4 inhibitors (DPP4i) among older adults type 2 diabetes (T2D). Methods Using U.S. Medicare administrative data from 2016 2020, we conducted population‐based cohort...
We review three principally different forms of injury-induced synaptic alterations. (1) Displacement presynaptic terminals from perikarya and dendrites axotomized neurons, (2) central changes in primary afferent peripherally sensory ganglion cells, (3) anterograde Wallerian-type degeneration following interruption axonal pathways. All these instances rapidly acativate astrocytes microglia the vicinity affected terminals. The evidence suggests that activated play important direct roles...
✓ The aim of the present study was to examine glial cell response and possible involvement complement cascade following a cerebral cortical contusion. lesion produced using standardized weight-drop technique in adult rats. blood-brain barrier damaged, as demonstrated by decrease immunoreactivity for tight junction protein normally expressed endothelial cells small vessels central nervous system. Increased microglial (OX42) astroglial (glial fibrillary acidic protein), well macrophages...
It was long held as an axiom that new neurons are not produced in the adult human brain. More recent studies have identified multipotent cells whose progeny express glial or neuronal markers. This discovery may lead to therapeutic strategies for CNS disorders, either by stimulating neurogenesis vivo transplanting progenitor (MPCs) been propagated and differentiated vitro. The clinical application of such approaches will be limited ability these develop into functional neurons. To facilitate...
Adult neural stem cells (NSCs) are believed to facilitate CNS repair and tissue regeneration. However, it is not yet clear how these influenced when the cellular environment modified during neurotrauma or neuroinflammatory conditions. In this study, we determine different proinflammatory cytokines modulate expression of TLR2 TLR4 in NSCs respond agonists. Primary cultures stem/progenitor isolated from subventricular zone brains adult Dark Agouti rats were exposed 1) supernatants activated...