A5055873668- Entrepreneurship Studies and Influences
- Innovation and Socioeconomic Development
- Mentoring and Academic Development
- Educational Leadership and Innovation
- Community Development and Social Impact
- Higher Education and Employability
- Reflective Practices in Education
- Education Systems and Policy
- Metabolism, Diabetes, and Cancer
- Computational Drug Discovery Methods
- Higher Education Learning Practices
- Family Business Performance and Succession
- Plant biochemistry and biosynthesis
- Higher Education Research Studies
- Higher Education Practises and Engagement
- Intergenerational Family Dynamics and Caregiving
- Cooperative Studies and Economics
- Religion, Society, and Development
- Pancreatic function and diabetes
- Coaching Methods and Impact
- Microfinance and Financial Inclusion
- Adult and Continuing Education Topics
- COVID-19 Pandemic Impacts
- Employment and Welfare Studies
- Health and Medical Research Impacts
University of Huddersfield
2015-2024
The Open University
2023
AstraZeneca (Sweden)
2021
Center for Health, Exercise and Sport Sciences
2021
AstraZeneca (United Kingdom)
2018-2019
Trinity College Dublin
2016
Health Education North West
2016
University College Cork
2016
Teesside University
2016
GlaxoSmithKline (United Kingdom)
2007-2008
AMPK (AMP-activated protein kinase) is activated allosterically by AMP and phosphorylation of Thr172 within the catalytic α subunit. Here we show that mutations in regulatory γ subunit reduce allosteric activation kinase AMP. In addition to its effect, significantly reduces dephosphorylation PP (protein phosphatase)2Cα. Moreover, a mutation almost completely abolishes inhibitory effect on dephosphorylation. We were unable detect any either LKB1 or CaMKKβ (Ca2+/calmodulin-dependent β) using...
Abstract Genome-wide association studies have uncovered thousands of common variants associated with human disease, but the contribution rare to disease remains relatively unexplored. The UK Biobank contains detailed phenotypic data linked medical records for approximately 500,000 participants, offering an unprecedented opportunity evaluate effect variation on a broad collection traits 1,2 . Here we study relationships between protein-coding and 17,361 binary 1,419 quantitative phenotypes...
AMP-activated protein kinase (AMPK) plays a key role in maintaining energy homeostasis. Activation of AMPK peripheral tissues has been shown to alleviate the symptoms metabolic diseases, such as type 2 diabetes, and consequently is target for treatment these diseases. Recently, small molecule activator (A-769662) was identified that had beneficial effects on metabolism ob/ob mice. Here we show A-769662 activates both allosterically by inhibiting dephosphorylation Thr-172, similar AMP....
The AMP-activated protein kinase (AMPK) is a member of growing family related kinases, including the SNF1 complex in yeast, which respond to nutritional stress. AMPK heterotrimeric catalytic subunit (α) and two regulatory subunits (β γ), proteins all three have been identified complex. We used two-hybrid system order identify interacting with (α2). Using this approach, we isolated novel AMPKβ isoform, designate AMPKβ2. N-terminal region β2 differs significantly from that previously...
Squalestatin 1 is a member of novel family fermentation products isolated from previously unknown Phoma species (Coelomycetes). potent, selective inhibitor squalene synthase, key enzyme in cholesterol biosynthesis; vitro, 50% inhibition activity observed at concentration 12 +/- 5 nM (range 4-22 nM). inhibits biosynthesis [14C]acetate by rat hepatocytes (50% 39 nM) and liver vivo. In marmosets, with lipoprotein profile similar to that man, squalestatin lowers serum up 75%. This compound will...
ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTSelective Plasma Hydrolysis of Glucocorticoid γ-Lactones and Cyclic Carbonates by the Enzyme Paraoxonase: An Ideal Inactivation MechanismKeith Biggadike, Richard M. Angell, Colin Burgess, Rosanne Farrell, Ashley P. Hancock, Andy J. Harker, Wendy R. Irving, Chris Ioannou, Panayiotis A. Procopiou, Rupert E. Shaw, Yemisi Solanke, Onkar Singh, Michael Snowden, Rob Stubbs, Sarah Walton, Helen WestonView Author Information Medicinal Chemistry,...
This study examined how the introduction of peer mentorship in an undergraduate health and social welfare programme at a large northern university affected student learning.Using ethnographic case approach, draws upon data collected from small group mentors their mentees over period one academic year using interviews, reflective journals, assessment course evaluation data.Analysis identified number key findings: improves performance for both mentee mentor; reduces stress anxiety, enhances...
The peptidoglycan of Staphylococcus aureus contains relatively short glycan chains and is highly cross-linked via its peptide chains. material from wild-type (strain H) mutants H28, H4B MR-1 was freed the teichoic-acid-linked component then hydrolysed by Chalaropsis muramidase to yield disaccharide-repeating units with attached peptides either non-cross-linked (monomer) or joined similar one (dimer), two (trimer) more (oligomer) cross links. resulting fragments were separated high-resolution...
This article presents an overview of the diary as a popular method for data collection in nursing and health research. The context using diaries tool is considered nature purpose its relationship with care are examined. author reflects on different types their use collection, explores advantages disadvantages approach to care.
Abstract In countries across the world, COVID-19 global health crisis is one of biggest challenges humanity has faced in recent times. There have been economic, social, political and cultural all parts society. Drastic measures had to be put place, with many injecting extra investment into sector generating support for people who cannot work due lockdown rules that implemented. The coronavirus pandemic forced institutions rethink how government state functions. Various institutions, from...
Recently, within the higher education system in United Kingdom, there has been close examination of way institutions teach and assess students. This scrutiny intensified by central government with proposed introduction Teaching Excellence Framework (TEF). The anticipated TEF demands that evaluate their teaching learning practices think new ways to develop excellent student experience. Self-determined resurfaced as a popular approach sector. At centre self-determined is concept heutagogy....
The chemical synthesis and structure-activity relationships of a novel series 17beta-glucocorticoid butyrolactones possessing either 16alpha,17alpha-isopropylidene or -butylidene group are described. sulfur-linked gamma-lactone was incorporated onto the 17beta-position androstane nucleus via Barton ester decarboxylation trapping generated 17-radical with butyrolactone disulfides. glucocorticoid were hydrolyzed in human plasma by enzyme paraoxonase to respective hydroxy acids, which very weak...
Over recent years the higher education sector has been encouraged to find different, effective and flexible ways of teaching. This enthusiasm is apparent more than ever before, as current British Conservative governmenthas produced a white paper on Teaching Excellence Framework (TEF). The TEF intends measure improve quality teaching learning within sector. With this proposed framework being introduced, universities will have think new learning. examines pedagogical approach self-determined...
COVID-19 has overwhelmed and stretched existing healthcare infrastructure in both developed developing economies pushed governmental response mechanisms to the brink. Globally, governments elicited call for corporate support, asking social entrepreneurs business ventures organise efforts build voluntary support large-scale needed during sudden lockdown disruptions. By April 2020, 26.5 million jobs were lost US alone (Lambert, 2020), global stocks plummeted at least 25% gross domestic product...
Staphylococcus aureus H growing exponentially was labelled with N-acetyl[14C]glucosamine, which became incorporated into the peptidoglycan. The portion of peptidoglycan not linked to teichoic acid (60–75% whole) degraded Chalaropsis muramidase yield disaccharide-peptide monomers and dimers, trimers oligomers formed by biosynthetic cross-linking monomers. degree O-acetylation these fragments also examined. Pulse-chase experiments showed that proportion label initially in monomer fraction...
Abstract Since the outbreak of COVID-19, social enterprise has experienced a renaissance. In public policy circles, entrepreneurship and innovation are perceived as economic development tools, in many parts world, catalysts for change that can have real impact by increasing employment communities well environmental challenges. At local level, enable to stay vibrant due organisations offering much-needed goods services. Social been acknowledged solution inequality issues society it develops...
Squalestatin analogues modified in the C1 side chain were prepared and evaluated for their ability to inhibit rat liver microsomal Candida squalene synthase (SQS) vitro. While maintaining 4,6-dimethyloctenoate or 4,6-dimethyloctanoate ester groups at C6, a number of modifications well tolerated. However, absence C6 group, similar caused substantial loss activity. Compounds also cholesterol biosynthesis vivo rats reduce serum levels marmosets. These studies revealed that compounds with SQS...
The purpose of the study was to examine mediation roles student satisfaction and entrepreneurial self-efficacy in nexus between education self-competencies within a social enterprise context. used cross-sectional survey design, with sampled population 185 business students from three universities (Accra Technical University, Cape Coast University Ghana) Ghana. A PLS-SEM approach relationships among independent–dependent constructs study. Entrepreneurial had positive significant...