A5101381313- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Spine and Intervertebral Disc Pathology
- Animal Disease Management and Epidemiology
- Cell death mechanisms and regulation
- interferon and immune responses
- Autoimmune Neurological Disorders and Treatments
- Genetic Neurodegenerative Diseases
- Pelvic and Acetabular Injuries
- vaccines and immunoinformatics approaches
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Hereditary Neurological Disorders
- Pulmonary Hypertension Research and Treatments
- Neurological Disease Mechanisms and Treatments
- Prion Diseases and Protein Misfolding
- Immunotherapy and Immune Responses
- Hepatitis B Virus Studies
- Inflammasome and immune disorders
- Phagocytosis and Immune Regulation
- Nuclear Receptors and Signaling
- Glycogen Storage Diseases and Myoclonus
Nanjing Drum Tower Hospital
2025
Nanjing University of Chinese Medicine
2025
South China Normal University
2024
Jilin University
2015-2023
Northeast Forestry University
2023
Second Military Medical University
2015-2023
First Hospital of Jilin University
2019-2023
Changhai Hospital
2015-2023
Shanghai University of Electric Power
2023
Chengdu Second People's Hospital
2023
ABSTRACT To evaluate vaccine efficacy in protecting against coxsackievirus A16 (CA16), which causes human hand, foot, and mouth disease (HFMD), we established the first neonatal mouse model. In this article, report data concerning CA16-induced pathological changes, demonstrate that anti-CA16 antibody can protect mice lethal challenge model could be used to efficacy. establish a model, BJCA08/CA16 strain (at 260 50% doses [LD 50 ]) was isolated from patient intracerebrally (i.c.) inoculate...
EV71 is one of major etiologic causes hand-foot-mouth disease (HFMD) and leads to severe neurological complications in young children infants. Recently inactivated vaccines have been developed by five manufactures clinically show good safety immunogenicity. However, the cross-neutralizing activity these remains unclear, particular interest because RNA recombination seen more frequently epidemics.In this post-hoc study, sera from a subset 119 infants two clinical trials subgenotype C4...
Hand, foot and mouth disease, associated with enterovirus 71 (EV71) infections, has recently become an important public health issue throughout the world. Serum neutralizing antibodies are major indicators of EV71 infection protective immunity. However, potential for cross-reactivity different genotypes subgenotypes is unclear. Here we measured cross-reactive antibody titers against or in sera collected from EV71-infected children vaccine-inoculated a phase III clinical trial...
Background In recent years, there has been increased interest in the use of ultrasound technology evaluation spinal and paraspinal regions. Objective This study aimed to investigate trends research from 1994 2015 compare contributions such different countries authors. Study design Bibliometric analysis. Setting Publications related were retrieved Web Science database. Methods Excel 2013, GraphPad Prism 5, VOSviewer used summarise bibliometric features, including number publications, citation...
Eucalyptol (1,8-cineole), the major constituent of eucalyptus oil (EO), was used in traditional medicine as a remedy for colds and bronchitis. This study aimed at clarifying effect eucalyptol on respiratory immune function CD8 CD4 cells, alveolar macrophages (AM). Thirty male Sprague-Dawley rats were divided into experimental control groups. The drug given once day 3 weeks group according to dose into: 30, 100, 300 mg·kg-1 Flow cytometry detect phagocytic CD4, cells AM bronchopulmonary...
Background Immune checkpoint inhibitors and cytokines have revolutionized tumor treatment but are still limited by dose-dependent toxicity efficacy. In situ vaccine platforms based on intelligent microbes promising therapeutic strategies that sustainably deliver drugs locally without causing severe systemic risks. Methods this study, we innovatively engineered a non-pathogenic, adjuvant-acting Mycobacterium smegmatis ( M. ) co-expresses programmed cell death-ligand 1 (PD-L1) inhibitor an...
The level of neutralizing antibodies (NtAb) induced by vaccine inoculation is an important endpoint to evaluate the efficacy EV71 vaccine. In order vaccine, here, we reported development a novel pseudovirus system expression firefly luciferase (PVLA) for quantitative measurement NtAb. We first evaluated and validated sensitivity specificity PVLA method. A total 326 serum samples from epidemiological survey 144 specimens 3 clinical trials vaccines were used, each specimen's was measured in...
Tumor necrosis factor-alpha-induced protein-8 like-3 (TNFAIP8L3, TIPE3) is a newly discovered member of TNFAIP8 family and regarded as lipid second messenger transfer protein that promotes cancer. Yet the nature cells tissues express TIPE3 has not been determined. In this study, we examined expression in various murine human by immunohistochemistry quantitative PCR. We found was almost identical most organs from mice. cytoplasmic expressed preferentially epithelial-derived with secretory...
Study Design. A retrospective study. Objective. The aim of this study is to introduce a novel regional predictor for sagittal balance in elderly populations and explore its effectiveness evaluating balance. Summary Background Data. Sagittal getting increasing recognition importance due significant association health-related quality life. However, no parameters could well reflect predict the whole Methods. Medical records patients our outpatient clinic from January 2012 2014 were reviewed...
Background: Percutaneous vertebroplasty (PVP) can not only alleviate pain but also restore mechanical stability with injection of bone cement, whereas it exhibits a poor effect on antitumor activity. But through combinations other therapies, may be possible to achieve the maximum in clinical treatment. Thus, this study is designed assess efficacy PVP separately combined 4 ways for spinal metastasis (SM) Study Question: Which combination treatment better metastasis, percutaneous...
Transcription factor EB (TFEB) is an important endogenous defensive protein that responds to ischemic stimuli. Acute stroke a growing concern due its high morbidity and mortality. Most survivors suffer from disabilities such as numbness or weakness in arm leg, facial droop, difficulty speaking understanding speech, confusion, impaired balance coordination, loss of vision. Although TFEB plays neuroprotective role, potential effect on remains unclear. This article describes the basic...
Retrospective study.The aim of this study was to assess long-term radiographic and clinical outcomes in Lenke 5C adolescent idiopathic scoliosis (AIS) patients after posterior selective fusion.Lenke AIS who underwent thoracolumbar/lumbar (TL/L) fusion our hospital from January 2007 2010 were recruited. Radiographic parameters measured preoperatively at the 3-month, 1-year, 2-year, 5-year, 10-year follow-ups. The SRS-22 (Scoliosis Research Society) questionnaire used outcomes.We included 37...
Enterovirus 71(EV71) has caused severe epidemics of hand, foot and mouth disease (HFMD) in the Asia Pacific recent years, particularly infants pre-school children. It become a serious public health threat, as currently there are no approved vaccines or antiviral drugs for EV71 infection. Many have been under development worldwide, however main focus is inactivated vaccines. For example, vaccine recently finished phase III clinical trial Mainland China. There very few studies on virus like...
Enterovirus 71 (EV71) is the key pathogen for Hand, Foot, and Mouth Disease (HFMD) can result in severe neurological complications death among young children. Three inactivated-EV71 vaccines have gone through phase III clinical trials demonstrated good safety efficacy. These will benefit children under threat of HFMD. However, potential immunization-related compatibility different enterovirus remains unclear, making it hard to include EV71 vaccine Expanded Program on Immunization (EPI)....
The aim of the study was to explore significance T1 pelvic angle (TPA) for assessment sagittal balance in a cohort Chinese patients with unspecific low back pain. TPA has been commonly used assess adult spinal deformity. However, whether could be pain effectively remains unanswered. Medical records outpatients who received treatment our outpatient clinic between September 2013 and November 2014 were reviewed. Demographic data radiographic collected. Correlation coefficients other parameters...
Up to 50% of hepatocellular carcinoma (HCC) is caused by hepatitis B virus (HBV) infection, and the surface protein HBV essential for progression HBV-related HCC. The expression large antigen (LHB) presented in HBV-associated HCC tissues significantly associated with development Gene set enrichment analysis revealed that LHB overexpression regulates cell cycle process. Excess cells induced chronic endoplasmic reticulum (ER) stress was correlated tumor growth vivo. Cell showed from G1 S phase...