A5005782659- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Drug Transport and Resistance Mechanisms
- Fatty Acid Research and Health
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Lipid metabolism and disorders
- Estrogen and related hormone effects
- Immune Response and Inflammation
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Lipid metabolism and biosynthesis
- Cardiovascular Disease and Adiposity
- Hormonal Regulation and Hypertension
- Research on Leishmaniasis Studies
- Diet and metabolism studies
- Immune cells in cancer
- Sphingolipid Metabolism and Signaling
- Phytoestrogen effects and research
- Inflammatory Biomarkers in Disease Prognosis
- Advanced Glycation End Products research
- Pancreatic function and diabetes
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2010-2024
Universidade de São Paulo
2006-2022
Mice expressing human cholesteryl ester transfer protein (huCETP) are more resistant to Escherichia coli bacterial wall LPS because death rates 5 days after intraperitoneal inoculation of were higher in wild-type than huCETP+/− mice, whereas all huCETP+/+ mice remained alive. After inoculation, plasma concentrations TNF-α and IL-6 increased less mice. vitro elicited lower production by CETP macrophages. In addition, RAW 264.7 murine macrophages on incubation with but decreased a...
Sepsis is a systemic inflammatory response to infection eliciting high mortality rate which serious health problem. Despite numerous studies seeking for therapeutic alternatives, the mechanisms involved in this disease remain elusive. In study we evaluated influence of cholesteryl ester transfer protein (CETP), glycoprotein that promotes lipids between lipoproteins, on mice. Human CETP transgenic mice were compared control (wild type, WT) after polymicrobial sepsis induced by cecal ligation...
Reduced estrogen levels result in loss of protection from coronary heart disease postmenopausal women. Enhanced and diminished atherosclerosis have been associated with plasma cholesteryl ester transfer protein (CETP); however, little is known about the role CETP-ovarian hormone interactions atherogenesis. We assessed severity diet-induced ovariectomized (OV) CETP transgenic mice crossbred LDL receptor knockout mice. Compared OV expressing (+), non-expressing (−) had higher total, VLDL-,...
The antiatherogenic functions of high density lipoprotein (HDL-C) include its role in reverse cholesterol transport, but to what extent the concentration HDL-C interferes with whole-body metabolism is unknown. Therefore, we measured markers body synthesis (desmosterol and lathosterol) intestinal absorption (campesterol β-sitosterol) healthy subjects that differ according their plasma concentrations.Healthy participants presented either low (< 40 mg/dl, n=33, 17 male 16 female) or (> 60...
In this work, we investigated the impact of testosterone deficiency and cholesteryl ester transfer protein (CETP) expression on lipoprotein metabolism diet-induced atherosclerosis. CETP transgenic mice nontransgenic (nTg) littermates were studied 4 weeks after bilateral orchidectomy or sham operation. Castrated had an increase in LDL fraction (+36% for +79% nTg mice), whereas HDL was reduced (-30% -11% mice). presented 1.7-fold higher titers anti-oxidized (Ox-LDL) antibodies than...
Abstract Background We have searched if plasma high density lipoprotein-cholesterol (HDL-C) concentration interferes simultaneously with whole-body cholesterol metabolism and insulin sensitivity in normal weight healthy adult subjects. Methods measured the activities of several components that are critically influenced by control lipoprotein subjects low HDL-C concentrations. These parameters included cholesteryl ester transfer protein (CETP), phospholipid (PLTP), lecithin acyl transferase...
Cholesterol-ester transfer protein (CETP) plays a role in atherosclerosis, the inflammatory response to endotoxemia and experimental human sepsis. Functional alterations lipoprotein (LP) metabolism immune cell populations, including macrophages, occur during sepsis may be related comorbidities such as chronic obstructive pulmonary disease (COPD). Macrophages are significantly associated with emphysema, depending on microenvironment, might exhibit an M1 or M2 phenotype. derived from...
CETP activity reduces plasma HDL-cholesterol concentrations, a correlate of an increased risk atherosclerotic events. However, our recent findings suggest that expression in macrophages promotes intracellular antioxidant state, free cholesterol accumulation and phagocytosis, attenuates pro-inflammatory gene expression. To determine whether affects atherosclerosis development, we transplanted bone marrow from transgenic mice expressing simian or non-expressing littermates into...
Non-cholesterol sterols are transported in plasma lipoproteins and consequently important cholesterol metabolism. We investigated the distribution of non-cholesterol sterol precursors synthesis (NCSPCS), oxysterols, phytosterols healthy subjects differing according to HDL-Cholesterol (HDL-C) levels. Elevated NCSPCS (desmosterol, lathosterol) High HDL group suggests that exports these from cells, but not metabolite 24-OHC which was higher Low than group. 27-hydroxycholesterol (27OH-C) levels...
The association between lipoprotein levels and late-onset neonatal sepsis has shown controversial results. aims are to assess lipid profile, cytokines, Monocyte-to-HDL (M/H) ratio as diagnostic prognostic markers for sepsis. This prospective study included 49 septic neonates 17 controls. Cholesterol (CT), Triglyceride (TG), Very-Low-Density (VLDLc), Low-Density (LDLc), High-Density Lipoproteins (HDLc) were measured at admission (D0) on days 3, 7 10 evaluate shock outcomes. Cytokines...
We determined the influence of fasting (FAST) and feeding (FED) on cholesteryl ester (CE) flow between high-density lipoproteins (HDL) plasma apoB-lipoprotein triacylglycerol (TG)-rich emulsions (EM) prepared with TG-fatty acids (FAs). TG-FAs varying chain lengths degrees unsaturation were tested in presence a fraction at d > 1.21 g/mL as source CE transfer protein. The from HDL to FED was greater than FAST TG-rich acceptor lipoproteins, 18% 14%, respectively. However, percent...
Introduction Pathogenesis of cutaneous leishmaniases involves parasite growth, persistent inflammation, and likely participation lipoproteins (LP). The cholesteryl ester transfer protein (CETP), involved in LP remodeling, has been shown to participate the inflammatory response evolution infectious conditions. Methods We evaluated impact presence CETP on infection by Leishmania (L.) amazonensis an experimental model leishmaniasis using C57BL6/J mice transgenic for human having as control...
Modifications in chylomicron metabolism caused by antihypertensive drugs were investigated hypertensive subjects because previous studies had indicated that diuretics and beta-blockers modify the plasma lipid concentrations through mechanisms not fully understood. A triglyceride-rich emulsion resembling lymph chylomicrons, labeled with ( 3 H) triolein 14 C) cholesteryl oleate, was infused intravenously into mildly patients after 8 weeks on placebo subsequently hydrochlorothiazide (n = 10) or...