A5066448362- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- MRI in cancer diagnosis
- Medical Image Segmentation Techniques
- Fetal and Pediatric Neurological Disorders
- Glioma Diagnosis and Treatment
- Neural dynamics and brain function
- Radiomics and Machine Learning in Medical Imaging
- Cell Image Analysis Techniques
- Medical Imaging Techniques and Applications
- Legal Education and Practice Innovations
- Memory and Neural Mechanisms
- Meningioma and schwannoma management
- Child and Animal Learning Development
- Brain Metastases and Treatment
- Reading and Literacy Development
- Rock Mechanics and Modeling
- Census and Population Estimation
- Geotechnical and Geomechanical Engineering
- Anesthesia and Neurotoxicity Research
- Medical Imaging and Analysis
- Medical Malpractice and Liability Issues
- Tumors and Oncological Cases
- Coal Properties and Utilization
Green Gas (Czechia)
2022-2023
Forschungszentrum Jülich
2018-2022
Children's Hospital of Philadelphia
2021
University Hospital Leipzig
2018
Leipzig University
2018
Max Planck Society
2011-2017
Max Planck Institute for Human Cognitive and Brain Sciences
2011-2017
St. Jude Children's Research Hospital
2012-2014
Otto-von-Guericke University Magdeburg
2011
University of Ostrava
2007
Diffusion tensor imaging revealed that trait anxiety predicts the microstructural properties of a prespecified fiber tract between amygdala and perigenual anterior cingulate cortex. Besides this particular pathway, it is likely other pathways are also affected. We investigated white matter differences in persons featuring an anxious or nonanxious personality, taking into account all potential pathway connections anxiety-related regions prefrontal cortex (PFC). Diffusion-weighted images,...
The aim of this study was to prospectively examine the effects hearing loss and posterior fossa syndrome (PFS), in addition age at diagnosis disease risk status, on change intellectual academic outcomes following treatment a large sample medulloblastoma patients. Data from least 2 cognitive assessments were available 165 patients (ages 3–21 years) treated with surgery, risk-adapted craniospinal irradiation, 4 courses chemotherapy stem cell support. Patients underwent serial evaluation...
Abstract The ability to attribute mental states other individuals is crucial for human cognition. A milestone of this reached around the age 4, when children start understanding that others can have false beliefs about world. neural basis supporting critical step currently unknown. Here, we relate behavioural change maturation white matter structure in 3- and 4-year-old children. Tract-based spatial statistics probabilistic tractography show developmental breakthrough belief associated with...
Based on an examination of current methods used to define and assess a defendant's competency stand trial, the authors propose assessment research instrument, referred as Interdisciplinary Fitness Interview (IFI). The IFI is structured interview rating scale designed take into account both legal mental health issues, calls for interdisciplinary approach competency. purpose present study was provide preliminary reliability validity data use in one jurisdiction. results are discussed terms...
There has been a recent increased interest in the structural connectivity of cortex. However, an important feature remains relatively unexplored; tract length. In this article, we develop approach to characterize fiber length distributions across human cerebral We used data from 76 participants Adult WU-Minn Human Connectome Project using probabilistic tractography. found that connections different lengths are not evenly distributed They form patterns where certain areas have high density...
Parameters of water diffusion in white matter derived from diffusion-weighted imaging (DWI), such as fractional anisotropy (FA), mean, axial, and radial diffusivity (MD, AD RD), more recently, peak width skeletonized mean (PSMD), have been proposed potential markers normal pathological brain ageing. However, their relative evolution over the entire adult lifespan healthy individuals remains partly unknown during early late adulthood, particularly for PSMD index. Here, we gathered analyzed...
Objective We investigated the 5-year postsurgical developmental trajectory of working memory (WM) in children with medulloblastoma using parent and performance-based measures. Method This study included 167 patients treated for medulloblastoma. Serial assessments WM occurred at predetermined time points 5 years. Results There was a subtle, statistically significant increase parental concern about WM, coupled decrease age-standardized scores on However, whole-group mean both measures remained...
Modern approaches to investigate complex brain dynamics suggest represent the as a functional network of regions defined by atlas, while edges structural or connectivity among them. This approach is also utilized for mathematical modeling resting-state dynamics, where applied parcellation plays an essential role in deriving model and governing results. There however no consensus empirical evidence on how given atlas affects outcome, choice still rather arbitrary. Accordingly, we explore...
In the normal aging process, functional connectome restructures and shows a shift from more segregated to integrated brain networks, which manifests itself in highly different cognitive performances older adults. Underpinnings of this reorganization are not fully understood, but may be related age-related differences structural connectivity, underlying scaffold for information exchange between regions. The structure-function relationship might promising factor understand neurobiological...
Diffusion MRI is a non-invasive method that potentially gives insight into the brain's white matter structure regarding pathway of connections and properties axons. Here, we propose novel global tractography named Plausibility Tracking provides most plausible pathway, modeled as smooth spline curve, between two locations in brain. Compared to other methods, plausibility tracking combines more complete connectivity pattern probabilistic with tracks are globally optimized using fiber...
Progressive cognitive decline following multimodal neurooncological treatment is a common observation in patients suffering from malignant glioma. Alterations of the default-mode network (DMN) represent possible source impaired neurocognitive functioning and were analyzed these patients. Eighty (median age, 51 years) with glioma (WHO grade IV glioblastoma, n = 57; WHO III anaplastic astrocytoma, 13; oligodendroglioma, 10) ECOG performance score 0-1 underwent resting-state functional MRI...
Sleep complaints are the most prevalent syndromes in older adults, particularly women. Moreover, they frequently accompanied with a high level of depression and stress. Although several diffusion tensor imaging (DTI) studies reported associations between sleep quality brain white matter (WM) microstructure, it is still unclear whether gender impacts effect on structural alterations, these alterations mediate effects emotional regulation. We included 389 participants (176 females, age = 65.5...
We hypothesized that there are several common risk factors associated with secondary carpal tunnel releases. Therefore, we chose to investigate these by analyzing the charts of those patients requiring a second release (CTR) procedure.A retrospective chart review was performed, and were identified searching hospital medical record databases using Common Procedural Terminology.Between January 1, 2000, March 31, 2004, 2357 had primary CTR, 48 them found have CTR (of 48, 9 diabetes mellitus, 11...
Mit der Zielsetzung, zusätzliche sonomorphologische Dignitätskriterien zu erarbeiten, wurde das Perfusionsverhalten von 63 vergrößerten Halslymphknoten (LK) mittels farbkodierter Duplexsonographie untersucht. Die Dignität untersuchten LK anschließend histologisch oder klinisch gesichert (29 Metastasen Plattenepithel-Karzinomen und 34 akute chronische Lymphadenitiden). Eine quantitative Auswertung Pulsatilitäts-Parameter Pourcelot-Verhältnis Mittlerer Pulsatilitäts-Index bei 51 lieferte...
The high spatial resolution of 7T MRI enables us to identify subtle volume changes in brain structures, providing potential biomarkers mental disorders. Most volumetric approaches require that similar intensity values represent tissue types across different persons. By applying colour-coding T1-weighted MP2RAGE images, we found the measurement accuracy achieved by high-resolution imaging may be compromised inter-individual variations image intensity. To address this issue, analysed...