Lukman Hakim Mohd Din

ORCID: 0000-0003-1246-4278
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About
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Research Areas
  • Computational Drug Discovery Methods
  • Cholesterol and Lipid Metabolism
  • Peroxisome Proliferator-Activated Receptors
  • Lipoproteins and Cardiovascular Health
  • Protein Kinase Regulation and GTPase Signaling
  • Marine Sponges and Natural Products
  • Plant biochemistry and biosynthesis
  • Cellular transport and secretion
  • Signaling Pathways in Disease

Universiti Malaysia Terengganu
2021-2022

Mortality• Life expectancy for the U.S. population in 2015 was 78.8 years, a decrease of 0.1 year from 2014.• The age-adjusted death rate increased 1.2% 724.6 deaths per 100,000 standard 2014 to 733.1 2015.• 10 leading causes remained same as 2014.Age-adjusted rates eight and decreased one.• infant mortality 589.5 live births not significantly different rate.• 2014, although two exchanged ranks.This report presents final data on by demographic medical characteristics.These provide...

10.7324/japs.2020.10813 article EN Journal of Applied Pharmaceutical Science 2020-08-04

A constantly elevated level of low-density lipoprotein cholesterol (LDL-C) is mainly associated with the development atherosclerosis. The use statins as a treatment for reducing plasma LDL-C levels has led, in some cases, to adverse side effects, including decrease hepatic LDL receptor (LDLR), responsible uptake circulating LDL-C. Proprotein convertase subtilisin/kexin type 9 (PCSK9) an enzyme directing LDLR–LDL-C complex lysosomal degradation upon transport into cells, preventing recycling...

10.3390/ph15030269 article EN cc-by Pharmaceuticals 2022-02-22

Acaudina molpadioides has been long used as traditional medicinal resources and reported to demonstrate various important bioactivities such anticoagulation, antithrombosis, anti-hyperglycemia anticancer. However, its lipid lowering activity is yet be fully explored. Proprotein convertase subtilisin/kexin type 9 (PCSK9) an enzyme that enhances the lysosomal degradation of hepatic low density lipoprotein receptor (LDLR) resulting in excessive accumulation plasma levels LDL-cholesterols...

10.1016/j.sjbs.2021.08.003 article EN cc-by-nc-nd Saudi Journal of Biological Sciences 2021-08-08
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