A5031906131- Heat shock proteins research
- Wnt/β-catenin signaling in development and cancer
- Glaucoma and retinal disorders
- Vestibular and auditory disorders
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Cystic Fibrosis Research Advances
- Computational Drug Discovery Methods
- Ocular Surface and Contact Lens
- Hippo pathway signaling and YAP/TAZ
- Tryptophan and brain disorders
- Diabetes and associated disorders
- Immune Response and Inflammation
- RNA and protein synthesis mechanisms
- Cancer-related gene regulation
- Optical Coherence Tomography Applications
- RNA modifications and cancer
- interferon and immune responses
- Organ and Tissue Transplantation Research
- Tracheal and airway disorders
- CAR-T cell therapy research
- Reconstructive Surgery and Microvascular Techniques
- Cancer Cells and Metastasis
- Nutrition, Genetics, and Disease
- Cardiac Fibrosis and Remodeling
Fudan University
2024-2025
Zhongshan Hospital
2024-2025
University of Illinois Urbana-Champaign
2025
Third Xiangya Hospital
2024
Central South University
2013-2024
Sun Yat-sen University
2024
Shenzhen Bao'an District People's Hospital
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Foshan University
2022-2023
Xiangya Hospital Central South University
2023
Background Immune checkpoint inhibitors (ICIs) therapy targeting programmed cell death 1 (PD-1)/programmed ligand (PD-L1) shows promising clinical benefits. However, the relatively low response rate highlights need to develop an alternative strategy target PD-1/PD-L1 immune checkpoint. Our study focuses on role and mechanism of annexin A1 (ANXA1)-derived peptide A11 degrading PD-L1 effect tumor evasion in multiple cancers. Methods Binding was identified by biotin pull-down coupled with mass...
Abstract Our previous study indicated that adhesion molecule catenin alpha‐like 1(CTNNAL1) is downregulated in airway epithelial cells of asthma patients and animal model but little known about how the CTNNAL1 affects pathogenesis. To reveal direct relationship between CTNNAL1, CTNNAL1‐deficient mouse bronchopulmonary tissue was constructed by introducing CTNNAL1‐siRNA sequence using adeno‐associated virus (AAV) as vector. The established stimulation house dust mite (HDM). After...
Abstract Background & Approach: Immune checkpoint blockade (ICB) therapy has shown promise for head and neck squamous cell carcinoma (HNSCC); however, response rates remain limited, with only a subset of patients exhibiting significant clinical benefits. Identifying non-invasive liquid biomarkers to predict ICB is crucial optimizing patient selection treatment strategies. In this study, we generate analyze time-series RNA T-cell receptor (TCR) sequencing data from blood in murine HNSCC...
Abstract Ovarian cancer is the most malignant gynecologic cancer. Previous studies found that lamin-A was associated with DNA damage repair proteins but underlying mechanism remains unclear. We speculate this may be related to its interacting proteins, such as Hsp90. The aim of study investigate effects Hsp90 on and chemoresistance ovarian cells. In our research, co-immunoprecipitation (co-IP) mass spectrometry (MS) were used identify interaction domain. Next, relationship between explored...
Persistent injury and the following improper repair in bronchial epithelial cells are involved pathogenesis of airway inflammation remodeling asthma. E-cadherin (ECAD) has been shown to be epithelium repair, but its underlying mechanisms this process is poorly understood. Here, we describe a previously undetected function ECAD regulating balance EMT MET during repair. Injury mice human (HBECs) was induced by successive ozone stress for 4 days at 30 min per day. overexpression HBECs stable...
Dysregulation of splicing factor expression plays a crucial role in the progression hepatocellular carcinoma (HCC). Our research found that level ZMAT2 was increased HCC, promoting proliferation HCC cells. RNAseq data indicated absence induced skipping exon mRNA, while RIPseq further revealed mRNA binding motifs ZMAT2. A comprehensive analysis and indicateed played maturation process TRIM28 mRNA. Knocking down led to deletion 25 bases 11 TRIM28, ultimately resulting nonsense-mediated decay...
Mucociliary clearance system is the primary innate defense mechanism of lung. It plays a vital role in protecting airways from microbes and irritants infection. system, which mediated by actions airway submucosal gland epithelial cells, critical multilayered via secreting fluids, electrolytes, antimicrobial anti-inflammatory proteins, mucus onto surfaces. Changes environment, drugs or diseases can lead to overproduction cilia dysfunction, turn decrease rate mucociliary enhance gathering. The...
The downregulation of adhesion molecule catenin alpha-like 1 (CTNNAL1) in airway epithelial cells asthma patients and house dust mite (HDM)-induced animal models was illustrated our previous study. It is assumed to contribute inflammation mucus hypersecretion. In this work, we further explore the underlying mechanism CTNNAL1 asthma.
Ectopic transplantation of the hand remains a rare, innovative yet valuable operation in select cases trauma and amputation. We aim to describe novel technique complex reconstruction using two‐stage ectopic implantation contralateral upper limb. A male patient with near complete avulsion amputation right limb at level mid‐forearm crushing injury his left was admitted after farming accident. The palm ectopically transplanted lower both limbs underwent debridement vacuum assisted dressings...
Abstract The aging of the immune system has profound implications for individual responses, yet precise quantification age remains a challenge. Analyzing single-cell peripheral blood mononuclear cells (PBMC) transcriptomics data from 981 healthy individuals, we developed IMMClock (IMMune Clock), human clock derived single cell transcriptomics. is first to accurately assess three major types, CD8+ T cells, CD4+ and NK at level. Testing ability these clocks capture dynamic process, show that...