A5009435309- Genomic variations and chromosomal abnormalities
- Autism Spectrum Disorder Research
- Laser-Plasma Interactions and Diagnostics
- Epigenetics and DNA Methylation
- Laser-Matter Interactions and Applications
- Congenital heart defects research
- Child Development and Digital Technology
- Genetics and Neurodevelopmental Disorders
- Genetic Syndromes and Imprinting
- ECG Monitoring and Analysis
- Quantum Information and Cryptography
- Laser-induced spectroscopy and plasma
- Medical Image Segmentation Techniques
- Kruppel-like factors research
- Water Quality Monitoring and Analysis
- Genomics and Chromatin Dynamics
- Image and Signal Denoising Methods
- Image Processing Techniques and Applications
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive biology and impacts on aquatic species
- Sarcoma Diagnosis and Treatment
- Ear Surgery and Otitis Media
- Ear and Head Tumors
- Genomics and Rare Diseases
- Phonocardiography and Auscultation Techniques
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022-2025
Chongqing Medical University
2022-2025
Institute of Applied Physics and Computational Mathematics
2013-2025
Peking University
2013-2025
Fujian Medical University
2024
Second Affiliated Hospital of Fujian Medical University
2024
Tangshan People's Hospital
2023
Southeast University
2012-2022
Qingdao National Laboratory for Marine Science and Technology
2022
Chinese Academy of Fishery Sciences
2022
We recently used in situ Hi-C to create kilobase-resolution 3D maps of mammalian genomes. Here, we combine these with new Hi-C, microscopy, and genome-editing experiments study the physical structure chromatin fibers, domains, loops. find that observed contact domains are inconsistent equilibrium state for an ordinary condensed polymer. Combining data novel mathematical theorems, show also not consistent a fractal globule. Instead, use simulations two models genome folding. In one,...
A new hybrid-drive (HD) nonisobaric ignition scheme of inertial confinement fusion (ICF) is proposed, in which a HD pressure to drive implosion dynamics increases via increasing density rather than temperature the conventional indirect (ID) and direct (DD) approaches. In this (combination ID DD) scheme, an assembled target spherical hohlraum layered deuterium-tritium capsule inside used. The lasers first shock perform symmetry produce large-scale corona plasma. Then, DD lasers, whose...
Autism is a neurodevelopmental disorder with increasing evidence of heterogeneous genetic etiology including de novo and inherited copy number variants (CNVs). We performed array comparative genomic hybridization using custom Agilent 1 M oligonucleotide intended to cover 197 332 unique exons in RefSeq genes; 98% were covered by at least one probe 95% three or more probes the focus on detecting relatively small CNVs that would implicate single protein-coding gene. The study group included 99...
The hotspots of structural polymorphisms and mutability in the human genome remain to be explained mechanistically. We examine associations with germline DNA methylation non-allelic homologous recombination (NAHR) mediated by low-copy repeats (LCRs). Combined evidence from four sperm methylome maps, evolution, population, previous genomic disease studies consistently points a strong association hypomethylation instability. Specifically, deserts, ∼1% fraction lowest germline, show tenfold...
The Heisenberg-Robertson uncertainty relation quantitatively expresses the impossibility of jointly sharp preparation incompatible observables. However it does not capture concept observables because can be trivial even for two We experimentally demonstrate new stronger relations proposed by Maccone and Pati [Phys. Rev. Lett. 113, 260401 (2014)] relating on that sum variances are valid in a state-dependent manner lower bound is guaranteed to nontrivial being state system measured. behaviour...
Testing quantum theory on macroscopic scales is a longstanding challenge whose solution could have significant impact physics. For example, laboratory tests (such as those anticipated in nanomechanical or biological systems) may look to rule out realism: the idea that properties of objects exist objectively and can be noninvasively measured. Such investigations are likely suffer from (i) stringent experimental requirements, (ii) marginal statistical significance, (iii) logical loopholes. We...
Abstract Transcriptional repressor GATA binding 1 (TRPS1), an atypical transcription factor, functions as a transcriptional and is also implicated in human cancers. However, the underlying mechanism of TRPS1 contributing to malignancy remains obscure. In current study, we report that recognizes both gene proximal distal start site (TSS) sequences repress expression. Co-IP mass spectrometry biochemical studies showed binds CHD4/NuRD(MTA2). Genome-wide molecular revealed CHD4/NuRD(MTA2)...
Nanobodies are single-domain antibodies that contain the unique structural and functional properties of naturally-occurring heavy chain in camelidae. As a novel class antibody, they show many advantages compared with traditional such as smaller size, higher stability, improved specificity, more easily expressed microorganisms. These unusual hallmarks make them promising tools basic research clinical practice. Although thousands nanobodies known to be published, no single database provides...
Ultrasound scanning anomalies in fetuses are a cause for concern and often necessitate further diagnostic procedures. This retrospective study evaluated the utility of trio whole exome sequencing (trio-WES) diagnosis with ultrasound anomalies. We included diagnosed fetal referred to First Affiliated Hospital Chongqing Medical University between November 2018 July 2023. Fetal were classified into structural anomalies, dynamic soft markers. Karyotype analysis, chromosomal microarray analysis...
Image rescaling (IR) seeks to determine the optimal low-resolution (LR) representation of a high-resolution (HR) image reconstruct high-quality super-resolution (SR) image. Typically, HR images with resolutions exceeding 2K possess rich information that is unevenly distributed across Traditional methods often fall short because they focus solely on overall scaling rate, ignoring varying amounts in different parts To address this limitation, we propose Block-Based Multi-Scale Rescaling...
SUMMARY The environmental concern about diffuse pollution from nitrogen (N) fertilizers has led to increased research on the diagnosis of crop N status. SPAD chlorophyll (Chl) meter is most commonly used tool for rice ( Oryza sativa L.) status diagnosis, but measurements are conducted at a specific point and readings affected by different leaf positions. Many per plant must be taken in order increase accuracy which limits its application. present paper attempts determine canopy level using...
This study proposes a novel method to mitigate stimulated Brillouin scattering (SBS) using multicolor alternating-polarization bundle light. The light combines multiwavelength, spike trains of uneven duration and delay for single beam alternating polarization beams. SBS suppression is verified three-dimensional large-scale laser plasma code. numerical results show that the reflectivity can be decreased by nearly two orders in low density plasma. proposed extend repetition time from several...
Abstract Background Autism is a complex disease involving both environmental and genetic factors. Recent efforts have implicated the correlation of genomic imprinting brain development in autism, however pathogenesis autism not completely clear. Here, we used bioinformatic tools to provide comprehensive analysis autism-related genes, imprinted genes spatially temporally differentially expressed human brain, aiming explore relationship between imprinting. Methods This study analyzed...
Abstract Protein Kinase D (PKD) family contains PKD1, PKD2, and PKD3 in human. Compared to consistent tumor‐suppressive functions of PKD1 breast cancer, how PKD2/3 cancer are not fully understood. In the current study, we found that PKD2 but were preferentially overexpressed involved regulating cell proliferation metastasis. Integrated phosphoproteome, transcriptome, interactome showed was associated with multiple cancer‐related pathways, including adherent junction, regulation actin...
Alcohol dependence (AD) is a complex disorder characterized by psychiatric and physiological on alcohol. AD reflected regular alcohol drinking, which highly inheritable. In this study, to identify susceptibility genes associated with we performed genome-wide association study of copy number variants (CNVs) in 2,286 Caucasian subjects Affymetrix SNP6.0 genotyping array. We replicated our findings 1,627 Chinese the same identified two CNVs, CNV207 (combined p-value 1.91E-03) CNV1836 3.05E-03)...
Because of the limited space, suture oral and maxillofacial surgery is a challenging task, which requires surgeons to master excellent techniques. This letter presents single-arm stapling robot for using magnesium alloy staples, as well strategy robot, can complete operation. The has six degrees freedom adjust position orientation, novel stapler with one degree at end robot. A special proposed reapproximate wound, featured staple two different length legs. introduces mechanism Moreover,...
We propose an automated algorithm for classifying diagnostic categories of otitis media (middle ear inflammation); acute media, with effusion and no effusion. Acute represents a bacterial superinfection the middle fluid sterile that tends to subside spontaneously. Diagnosing children is hard, leading overprescription antibiotics are beneficial only prompting need accurate algorithm. To end, we design feature set understood by both otoscopists engineers based on actual visual cues used...
Pediatric elbow fractures pose a common diagnostic challenge in the field of pediatric orthopedics. Accurate diagnosis these through X-ray images is crucial clinical practice, often requiring highly specialized medical imaging experts. In recent years, development deep learning technology has provided new approach to address this issue. This study aims explore potential using convolutional neural network (DCNN) technology, specifically DenseNet-201 model, for diagnosing from images. utilized...