A5103032284- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Systemic Sclerosis and Related Diseases
- Atherosclerosis and Cardiovascular Diseases
- Inflammatory Myopathies and Dermatomyositis
- Hepatitis C virus research
- Salivary Gland Disorders and Functions
- COVID-19 Clinical Research Studies
- Lipoproteins and Cardiovascular Health
- Healthcare professionals’ stress and burnout
- Dermatological and COVID-19 studies
- Herpesvirus Infections and Treatments
- Innovations in Medical Education
- Urticaria and Related Conditions
- Mycobacterium research and diagnosis
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Salivary Gland Tumors Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 and COVID-19 Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
China Medical University Hospital
2017-2025
Chung Shan Medical University
2016-2025
China Medical University
2017-2025
National Yang Ming Chiao Tung University
2008-2025
National Chung Hsing University
2009-2025
China Medical University
2021-2024
Center for Rheumatology
2021-2024
Chung Shan Medical University Hospital
2023-2024
International Baccalaureate
2024
Indiana University School of Medicine
2024
Abstract Background Resilience refers to the ability be flexible and adaptive in response challenges. Medical students clerkship who are transitioning from medical studies clinical practice face a variety of workplace demands that can lead negative learning experiences poor quality life. This study explored whether students’ resilience plays protective role against stresses incurred during training on their professional life clerkships. Methods was 1-year prospective web-based questionnaire...
This study was undertaken to estimate the cumulative incidence rate of rheumatoid arthritis (RA) in Taiwanese population ages 16-84 years, and life expectancy, loss lifetime health care expenditures for incident RA Taiwan after 2003, when biologics began be prescribed.We obtained all claims data period 1999 2016 from National Health Insurance program Taiwan, validated against Catastrophic Illness Registry establish cohort. We estimated survival function extrapolated using a rolling-over...
This paper proposed the forecasting model of Influenza-like Illness (ILI) and respiratory disease. The dataset was extracted from Taiwan Environmental Protection Administration (EPA) for air pollutants data Centers Disease Control (CDC) disease cases 2009 to 2018. First, this applied ARIMA method, which trained based on weekly number in time series. Second, we implemented Long short-term memory (LSTM) correlation between diseases pollutants. models were also evaluated five ten years...
Abstract Objective This study aimed to assess the incidence and risk factors surrounding mental illnesses in patients diagnosed with systemic autoimmune rheumatic diseases (SARDs). Methods retrospective cohort used nationwide, population-based claim data taken from Taiwan’s National Health Insurance Research Database (NHIRD) identify certified as having a catastrophic illness for lupus erythematosus (SLE), rheumatoid arthritis (RA), sclerosis (SSc), dermatomyositis (DM), polymyositis (PM) or...
Low-density lipoprotein (LDL)-cholesterol (LDL-C) promotes atherosclerotic cardiovascular disease (ASCVD), with changes in LDL electronegativity modulating its pro-atherogenic/pro-thrombotic effects. Whether such alterations associate adverse outcomes patients acute coronary syndromes (ACS), a patient population at particularly high risk, remains unknown.This is case-cohort study using data from subset of 2619 ACS prospectively recruited four university hospitals Switzerland. Isolated was...
Abstract Background Neutralizing anti-interferon (IFN)-γ autoantibodies are linked to adult-onset immunodeficiency and opportunistic infections. Methods To explore whether anti-IFN-γ associated with disease severity of coronavirus 2019 (COVID-19), we examined the titers functional neutralization in COVID-19 patients. In 127 patients 22 healthy controls, serum were quantified using enzyme-linked immunosorbent assay, presence was verified immunoblotting assay. The neutralizing capacity against...
Pneumocystis pneumonia (PCP) is increasingly being diagnosed in patients with systemic lupus erythematosus (SLE), and hydroxychloroquine (HCQ) has been found to possess antifungal activities. We hence aimed investigate the association between HCQ PCP risk among SLE.Using 1997-2013 nationwide claim data, we identified 24,343 newly-diagnosed SLE patients. then 58 cases selected 348 non-PCP controls matching (1:6) by age, sex, disease duration year of diagnosis date. The was assessed determing...
Background: Rheumatoid arthritis (RA) is complicated by a high risk of cardiovascular disease and requires the initiation biological or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) for persistently active despite first-line therapies. The influence b/tsDMARDs, especially tsDMARDs, on in Taiwanese patients with RA remains unclear. Objectives: To compare major adverse events (MACEs) venous thromboembolism (VTE) amongst initiating approved b/tsDMARDs up to 5 years....
The aim of this study was to assess the association between air pollutant exposure and interstitial lung disease (ILD) in patients with connective tissue diseases (CTDs).A nationwide, population-based, matched case-control Taiwan.Using 1997-2013 Taiwanese National Health Insurance Research Database, we identified newly diagnosed CTD during 2001-2013, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), sclerosis (SSc), dermatomyositis (DMtis)/polymyositis (PM) primary...
Dendritic cells (DCs) play an important role in connecting innate and adaptive immunity. Thus, DCs have been regarded as a major target for the development of immunomodulators. In this study, we examined effect dextromethorphan (DXM), common cough suppressant with high safety profile, on activation function DCs. presence DXM, LPS-induced expression costimulatory molecules murine bone marrow-derived dendritic (BMDCs) was significantly suppressed. addition, DXM treatment reduced production...
Abstract Background Service learning (SL) is an educational methodology presumed to help medical students be more empathetic and compassionate. We longitudinally investigated the level of empathy in how preclinical SL experience was related their clinical clerkships. Methods Our cohort comprised fifth-year engaged clerkships as part a 7-year programme at one school Taiwan. Surveys were conducted beginning clerkship September 2015 (T1) collect data on students’ curriculum-based service teams...
To explore prevalence and related factors for urinary incontinence (UI) among the oldest old institutionalized Chinese men in Taiwan.All residents living Banciao Veterans Care Home were invited study. UI was defined as leakage at least once weekly. Additional data items from Minimum Data Set (MDS Nursing Version 2.1) used to impact associated with physical function, cognitive status quality of life (social engagement, SocE). Depressive symptoms screened by Short Form Geriatric Depression...
Objective To address the association between a history of tuberculosis (TB) or nontuberculous mycobacterial (NTM) infection and risk newly diagnosed Sjögren’s syndrome (SS). Methods Using nationwide, population-based, claims dataset, after excluding those who had rheumatoid arthritis systemic lupus erythematosus, we identified 5,751 SS cases during 2007–2012, compared them to 86,265 non-SS controls matched (1:15) for age, sex, year first diagnosis date. The incident infection, including TB...
Rheumatoid arthritis (RA), a chronic inflammatory disease, carries significant burden of atherosclerotic cardiovascular diseases (ASCVD). With their heterogeneous composition, high-density lipoprotein (HDL) particles have varied athero-protective properties, and some may even increase ASCVD risk. In this prospective cross-sectional study, we aimed to examine the relationship between HDL sizes/metabolites inflammation in RA. Using 1H-NMR-based lipid/metabolomics, differential HDL-related...
Neutrophil extracellular traps (NETs) formation, namely NETosis, is implicated in antiphospholipid syndrome (APS)-related thrombosis various autoimmune disorders such as systemic lupus erythematosus (SLE) and APS. Human parvovirus B19 (B19V) infection closely associated with SLE APS causes clinical manifestations blood disorders, joint pain, fever, pregnancy complications, thrombosis. Additionally, B19V may trigger the production of autoantibodies, including those against nuclear...
L5, the most negatively charged subfraction of low-density lipoprotein (LDL), is implicated in atherogenesis. We examined relationship between plasma L5 levels and occurrence subclinical atherosclerosis patients with rheumatoid arthritis (RA). Using anion-exchange purification fast-protein liquid chromatography, we determined proportion LDL (L5%) 64 RA 12 healthy controls (HC). Plasma L5% were significantly higher (median, 1.4% 1.92 mg/dL) compared HC (0.9%, p < 0.005; 1.27 mg/dL, 0.05)...