A5074968582- Synthesis of Organic Compounds
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Synthesis of heterocyclic compounds
- Synthesis and Reactions of Organic Compounds
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Multicomponent Synthesis of Heterocycles
- Synthesis and Characterization of Heterocyclic Compounds
- Sulfur-Based Synthesis Techniques
- Ion Channels and Receptors
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Catalytic Reactions
- Cholinesterase and Neurodegenerative Diseases
- Natural Compound Pharmacology Studies
- Photochromic and Fluorescence Chemistry
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Synthesis and Reactivity of Heterocycles
- Supramolecular Self-Assembly in Materials
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Synthesis of Indole Derivatives
- Bioactive Compounds and Antitumor Agents
- Lipid Membrane Structure and Behavior
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
Saint - Petersburg State Chemical Pharmaceutical Academy
2015-2024
St Petersburg University
2020-2023
Ministry of Health of the Russian Federation
2022
Introduction. The search for effective approaches to the treatment of anxiety disorders, in particular, development and study drugs with anxiolytic action, is currently one most urgent tasks neurobiological research. behavioral changes Danio rerio after exposure a new group substances – chromone-containing allylmorpholines revealed their ability exert dose-dependent sedation, compounds series (E)-4-[3-(6-chloro-4-oxo-4H-chromene-3-yl)-4-cyclohexylallyl]morpholin-4-ium chloride (33a),...
The [4+2] cycloaddition of chromone‐fused dienes with enamines was found to be an efficient method for the synthesis 4,4a‐ and 3,4‐dihydroxanthone derivatives. Either product type could obtained by choosing proper conditions [reaction time addition La(NO 3 ) as a Lewis acid]. Calculations using density functional theory Møller–Plesset perturbation showed that isomerization 4,4a‐dihydroxanthones 3,4‐dihydroxanthones occurred through base‐assisted sigmatropic rearrangement. described reaction...
The first example of an unusual addition chromone‐substituted acrylic acid to enamines is described. process shows high versatility concerning both and chromones. reaction catalyzed by tertiary amines highly likely Morita–Baylis–Hillman‐type. described compounds show combined moderate inhibitory action on BChE antagonism towards NMDA receptors which makes them a perspective group for the development anti‐Alzheimer drugs.
We report an easy and powerful approach to the synthesis of novel chromeno[4,3-d]pyrimidine-5-acetic acids through ANRORC reaction electron-deficient 3-vinylchromones 1,3-N,N-binucleophiles. The proceeds under mild conditions (EtOH, rt) is applicable a wide range substrates. described compounds show fluorescence in violet-blue (390–460 nm) with Stokes shift 40–80 nm moderate quantum yield (0.15–0.20). As electron-withdrawing group conserved form acetic acid fragment, these may readily be...
Abstract We report the development of a convenient organocatalytic method for synthesis 5 H ‐pyrano[3,2‐ c ]chromenes from chromone‐containing acrylates and ethyl cyanoacetate. The is characterized by simple conditions (ethanol, basic catalysis) good yields (up to 90 %). synthesized pyrano[3,2‐ are promising new class fluorescent compounds. They have intense fluorescence in yellow‐green region spectrum (495–554 nm) with high quantum 72 %) exhibit large Stokes shifts (3514–5856 cm −1 )....
Abstract We report a flexible approach to the synthesis of phenanthrene‐like heterocycles through organocatalytic ANRORC (Addition Nucleophile, Ring Opening, and Closure) reaction electron‐deficient 3‐vinylchromones with cyanoacetamide. Addition highly basic DBU (1,8‐diazabicyclo[5.4.0]undec‐7‐ene) or tetramethylguanidine (TMG) at 80 °C leads chromeno[4,3‐ b ]pyridines in good yields, whereas Et 3 N 20 made it possible obtain less accessible pyrano[3,2‐ c ]chromenes their 2‐imines. The...
Abstract We studied a reaction of chromone‐containing acrylonitriles and cyanoacrylates with acid hydrazides. This turned out to be method for the synthesis salicyloyl‐substituted 1,2,4‐triazolo[1,5‐ ]pyridines. The developed is tandem ring‐opening/double ring‐closing process. synthetic approach characterized by low toxic solvents (ethanol, butanol) mediator (Et 3 N), 37–84% yields, non‐chromatographic isolation products, substrate tolerance (59 examples).
Abstract Obtaining highly functionalized heterocyclic structures is an important topic of modern organic synthesis, as it reveals the possibility constructing more complex systems and therefore, expanding range various drugs. Aiming at synthesizing molecules from simple readily available reagents, modification C,N ‐diarylformamidines, well known in medicinal chemistry, great interest. This article reviews comprehensively field ‐diarylformamidine chemistry covers publications on this 1999 to 2022.
Introduction. Irrational use of antimicrobial drugs, chemical and biological agents leads to the emergence spread resistance in microorgan-isms. Therefore, there is an increasing need for search development new compounds. Dihydroxanthone derivatives, which have a wide spectrum action, are one promising groups substances. New derivatives 4,4a-dihydroxanthone were obtained at St. Petersburg State Chemical Pharmaceutical University (SPCFU) Department Organic Chemistry. Synthetic...
Herein, we report that chromone-containing allylmorpholines can affect ion channels formed by pore-forming antibiotics in model lipid membranes, which correlates with their ability to influence membrane boundary potential and lipid-packing stress. At 100 µg/mL, 1, 6, 7, 8 decrease the of bilayers composed palmitoyloleoylphosphocholine (POPC) about mV. same time, compounds do not zeta-potential POPC liposomes, but reduce dipole 80-120 The allylmorpholine-induced drop produce 10-30%...
Introduction. Partially hydrogenated derivatives of xanthone, dihydroxanthones, are being intensively studied. They interest due to their antimicrobial, antitumor, and antioxidant effects. Many researches focused on the study cytotoxicity dihydroxanthones very little information is available antimicrobial activity. Therefore, activity mechanism action new synthetic 4,4a-dihydroxanthone relevant. Preliminary studies have demonstrated that 4,4a-dihydroxanthones active against gram-positive...