A5018935734- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Ion Channels and Receptors
- Cardiac electrophysiology and arrhythmias
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- Neurological diseases and metabolism
- Neuroscience and Neuropharmacology Research
- Calcium signaling and nucleotide metabolism
- Nuclear Receptors and Signaling
- Nicotinic Acetylcholine Receptors Study
- Neurological disorders and treatments
- Cannabis and Cannabinoid Research
- Trypanosoma species research and implications
- Cholinesterase and Neurodegenerative Diseases
Institute of Cytology
2019-2023
Huntington's disease (HD) is a severe autosomal-dominant neurodegenerative disorder caused by mutation within gene, encoding huntingtin protein. Here we have used the induced pluripotent stem cell technology to produce patient-specific terminally differentiated GABA-ergic medium spiny neurons modeling juvenile form of HD (HD76). We shown that calcium signaling dramatically disturbed in HD76 neurons, specifically demonstrating higher levels store-operated and voltage-gated uptakes. However,...
About 15% of patients with parkinsonism have a hereditary form Parkinson’s disease (PD). Studies on the early stages PD pathogenesis are challenging due to lack relevant models. The most promising ones models based dopaminergic neurons (DAns) differentiated from induced pluripotent stem cells (iPSCs) forms PD. This work describes highly efficient 2D protocol for obtaining DAns iPSCs. is rather simple, comparable in efficiency previously published protocols, and does not require viral...