A5030324762- Neurological and metabolic disorders
- Parkinson's Disease Mechanisms and Treatments
- Epilepsy research and treatment
- Acute Ischemic Stroke Management
- Genetic Neurodegenerative Diseases
- Peripheral Neuropathies and Disorders
- Multiple Sclerosis Research Studies
- Mental Health Treatment and Access
- Mitochondrial Function and Pathology
- Neurological disorders and treatments
- Stroke Rehabilitation and Recovery
- Myasthenia Gravis and Thymoma
- Schizophrenia research and treatment
- Vasculitis and related conditions
- Ocular Diseases and Behçet’s Syndrome
- Pharmacological Effects and Toxicity Studies
- Autoimmune Neurological Disorders and Treatments
- Cerebral Venous Sinus Thrombosis
- Pituitary Gland Disorders and Treatments
- Bipolar Disorder and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Healthcare Decision-Making and Restraints
- Sarcoidosis and Beryllium Toxicity Research
- Venous Thromboembolism Diagnosis and Management
- Metabolism and Genetic Disorders
University of Sharjah
2025
Qatar University
2024
Memorial Healthcare System
2024
University of Monastir
2007-2023
Centre Hospitalier Universitaire Hassan II
2016
Charité - Universitätsmedizin Berlin
2013-2015
Hospital Fatuma Bourguiba Monastir
2002-2014
Military Hospital of Tunis
2013
Hopital Universitaire Hedi Chaker
2013
Hôpital Lyon Sud
2004
To determine the usefulness of [18F]fluorodeoxyglucose (FDG) whole body FDG-PET in diagnosis tumours patients with paraneoplastic neurological syndromes (PNS), we prospectively studied 20 antibodies whom conventional imaging gave negative or inconclusive results for presence tumour. All had manifestations compatible PNS and well-characterized (12 anti-Hu, one anti-Hu anti-CV2, four anti-Yo, anti-Ri anti-amphiphysin). The mean delay between onset symptoms was 10 months (range 1-54). In these...
Oxidative stress and generation of reactive oxygen species are believed to be implicated in Parkinson’s disease (PD). Erythrocyte activity superoxide dismutase (SOD) catalase, the blood glutathione system, plasma levels thiobarbituric-acid-reactive substances (TBARS) were measured 80 PD patients. These biochemical parameters also 29 age-matched controls. Patients with had significantly higher red corpuscle (RBC) SOD. The mean RBC catalase patients did not differ from those was lower advanced...
Over the past few decades, researchers have attempted to overcome disadvantages of metallic stents. This led birth first “Bioresorbable Scaffold” (BRS) model, Absorb Bioresorbable Vascular Scaffold (BVS), in 1999 by Abbott. A stent that spontaneously resorbs shows a promising theoretical minimal risk long-term thrombosis and omits need for antiplatelet therapy. However, only one year after its Food Drug Administration (FDA) approval 2016, it was voluntarily withdrawn owing concerns regarding...
Congenital adrenal hyperplasia (CAH) is an inherited recessive disorder of steroidogenesis. The enzymes most commonly affected are 21-hydroxylase. Past reports suggested brain magnetic resonance imaging (MRI) abnormalities in CAH patients, affecting white matter signal, temporal lobe and amygdala structure function.In the present study, we aimed to investigate frequency changes lobes structures dysgenesis a population patients having due 21-hydroxylase deficiency.Neurological examination MRI...
VEXAS syndrome (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) is a novel disorder first described in 2020. Patients are diagnosed by identifying somatic mutation of the ubiquitin-like modifier-activating enzyme 1 (UBA1) gene. They usually have systemic inflammation and present with combination hematologic rheumatologic abnormalities such as myelodysplastic polychondritis. patients at increased risk developing malignancies. We case 60-year-old male who developed...
We report a case of 15-yr-old child that was presented with headache, polyuria, polydipsia, recent ocular motor and abducens nerve palsies rapid visual loss. He had long history progressive symmetric muscular weakness predominant in the lower limb girdle. Water deprivation revealed central diabetes insipidus. Hormonal explorations demonstrated preserved pituitary function mild hyperprolactinemia at 21.5 ng/ml (N: 2.6 to 13.1 ng/ml). Magnetic resonance imaging showed an extensive isosignal T1...
A 15-yr-old male patient with congenital adrenal hyperplasia (CAH) was referred to our department a one year history of gradual worsening tremors. He diagnosed salt-wasting 21-hydroxylase deficiency CAH at 40 d old and started on hydrocortisone, fludrocortisone salt. found have hypertension 8 yr age. Detailed investigations failed detect any cause for secondary hypertension. Physical findings the current hospitalization objectified obesity, blood pressure 150/80 mmHg, postural action tremor,...
A 45-year-old male was referred for diabetes mellitus. Clinical examination found a family history of multiple precocious deaths, strong consanguinity, personal seizures during childhood, small testicles, penis, sparse body hair, long arms and legs, dysmorphic features, mental retardation, dysarthria, tremor, mild gait ataxia. Investigations pigmentary retinitis, metabolic syndrome, unilateral renal aplasia, hypergonadotropic hypogonadism, ruled out mitochondrial cytopathy leucodystrophy....
Various endocrine manifestations are commonly described in myotonic dystrophy (MD), including primary hypogonadism, diabetes mellitus, and thyroid parathyroid dysfunction. We describe a 46-year-old woman with family history of MD her son. She was diagnosed cardiac arrhythmia required the implantation pacemaker. noted to have bilateral cataract. complained muscle weakness, diffuse myalgia, palpitation. The electromyography (EMG) showed discharges. Laboratory tests high serum calcium 2.83...
Behçet's disease (BD) is a multisystem vascular inflammatory with several clinical manifestations. Intracranial aneurysms are an extremely rare but nevertheless severe complication of BD. We report case 44-year-old man. The diagnosis BD was made based on the presence recurrent oral aphthous ulcers and positive human leukocyte antigen (HLA-) B51 in absence evidence other diseases. MRI showed ancient ischemic right capsulolenticular lesion, subacute white matter hypersignals left capsule...
We report a 62 year-old-man with facial cellulitis revealing choreo-acanthocytosis (ChAc). He showed chorea that started 20 years ago. The orofacial dyskinisia tongue and cheek biting resulted in cellulitis. peripheral blood smear revealed acanthocytosis of 25%. overall chorea, dyskinetic disorder, neuropathy, disturbed behavior, the atrophy caudate nuclei was suggestive diagnosis ChAc. To our knowledge no similar cases (ChAc) were found review literature.
Leigh syndrome (LS) is a mitochondrial disease characterized by subacute necrotizing encephalomyelopathy with an estimated incidence of 1:40,000 births. The comorbidity psychotic symptoms noted in and psychiatric diseases has spurred interest the effects DNA mutations disorders. Case presentation. We report case Tunisian 28-year-old male diagnosed maternally inherited syndrome. He presented anxiety auditory hallucinations, he reported vague, unsystematized delusion evolving since 6 months....