A5043149496- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- Sphingolipid Metabolism and Signaling
- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Lipid metabolism and biosynthesis
- Essential Oils and Antimicrobial Activity
- Antioxidant Activity and Oxidative Stress
- Nutrition and Health in Aging
- Receptor Mechanisms and Signaling
- Frailty in Older Adults
- Phytochemicals and Antioxidant Activities
- Nuclear Receptors and Signaling
- Edible Oils Quality and Analysis
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Steroid Chemistry and Biochemistry
- Medicinal Plants and Neuroprotection
- Ethnobotanical and Medicinal Plants Studies
- Alzheimer's disease research and treatments
- Plant biochemistry and biosynthesis
- Sirtuins and Resveratrol in Medicine
- Ginger and Zingiberaceae research
- Immune cells in cancer
- Atherosclerosis and Cardiovascular Diseases
University of Monastir
2016-2025
University College Cork
2014-2025
Université de Bourgogne
2012-2025
University of Sousse
2016-2024
Mount Sinai Medical Center
2023-2024
Icahn School of Medicine at Mount Sinai
2023-2024
University of Gabès
2023
Laboratoire Bio-peroxIL
2012-2021
Grand Charleroi Hospital
2019-2020
Inserm
2012-2017
The effects of vegetable oils on human health depend their components. Therefore, profiles lipid nutrients and polyphenols were determined.To establish compare the fatty acid, tocopherol, phytosterol polyphenol Mediterranean oils: cosmetic dietary argan (AO; Morocco: Agadir, Berkane); olive (OO; Morocco, Spain, Tunisia); milk thistle seed (MTSO; Tunisia: Bizerte, Sousse, Zaghouane); nigella oil (NSO).The biochemical determined by gas chromatography-flame ionization, high performance liquid...
The development of digital technologies and the evolution open innovation approaches have enabled creation diverse virtual organizations enterprises coordinating their activities primarily online. platform titled "International Natural Product Sciences Taskforce" (INPST) was established in 2018, to bring together collaborative environment individuals interested natural product scientific research, empower interactions by using communication tools.In this work, we present a general overview...
Nutritional choices, which include the source of dietary fatty acids (FA), have an important significant impact on coronary artery disease (CAD). We aimed to determine patients with CAD relationships between Trans (Trans FA) and different associated parameters such as inflammatory oxidative stress in addition Gensini score a vascular severity index. Fatty acid profiles were established by gas chromatography from 111 compared 120 age-matched control group. Lipid peroxidation biomarkers,...
Lipid peroxidation products, such as 7-ketocholesterol (7KC), may be increased in the body fluids and tissues of patients with neurodegenerative diseases trigger microglial dysfunction involved neurodegeneration. It is therefore important to identify synthetic natural molecules able impair toxic effects 7KC. We determined impact 7KC on murine BV-2 cells, especially its ability mitochondrial peroxisomal dysfunction, evaluated protective α- γ-tocopherol, Trolox, oleic acid (OA). Multiple...
The Mediterranean diet is associated with health benefits due to bioactive compounds such as polyphenols. biological activities of three polyphenols (quercetin (QCT), resveratrol (RSV), apigenin (API)) were evaluated in mouse neuronal N2a cells the presence 7-ketocholesterol (7KC), a major cholesterol oxidation product increased patients age-related diseases, including neurodegenerative disorders. In cells, 7KC (50 µM; 48 h) induces cytotoxic effects characterized by an induction cell death....
Abstract Background Frailty is a multidimensional syndrome that leads to an increase of age-related disorder several physiological systems, and cognitive abilities decline. The aim this study was evaluate the prevalence frailty among older persons in Belgium we examined factors associated with principal focus en cognitive, dietary status, inflammatory parameters. Methods A total 124 participants (90 women, 34 men; age: mean ± SD: 85.9 5.5 years) were studied, recruited from Geriatrics...
In Alzheimer's disease, lipid alterations point towards peroxisomal dysfunctions. Indeed, a cortical accumulation of saturated very long chain fatty acids (VLCFAs: C22:0, C24:0, C26:0), substrates for β-oxidation, has been found in Alzheimer patients. This study was realized to investigate the effects VLCFAs at mitochondrial level since dysfunctions play crucial roles neurodegeneration. On human neuronal SK-NB-E cells treated with or C26:0 (0.1-20 μM; 48 h), an inhibition cell growth and...
Graphical abstract Abstract 7-Ketocholesterol (or 7-oxocholesterol) is an oxysterol essentially formed by cholesterol autoxidation. It often found at enhanced levels in the body fluids and/or target tissues of patients with age-related diseases (cardiovascular, neuronal, and ocular diseases) as well subjects concerned civilization (type 2 diabetes, bowel diseases, metabolic syndrome). The involvement increased 7-ketocholesterol pathophysiology these widely suspected. Indeed, elevated...