A5029824649- Mitochondrial Function and Pathology
- Genetics and Neurodevelopmental Disorders
- Ubiquitin and proteasome pathways
- Metabolism and Genetic Disorders
- Down syndrome and intellectual disability research
- Autism Spectrum Disorder Research
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Enzyme Structure and Function
- Sirtuins and Resveratrol in Medicine
- ATP Synthase and ATPases Research
- Protein Structure and Dynamics
- Pancreatic function and diabetes
- Adenosine and Purinergic Signaling
- Amino Acid Enzymes and Metabolism
- Cell Adhesion Molecules Research
- Photoreceptor and optogenetics research
- Cannabis and Cannabinoid Research
- Laser Applications in Dentistry and Medicine
- Retinoids in leukemia and cellular processes
- Plant Stress Responses and Tolerance
- Vitamin C and Antioxidants Research
- Metabolomics and Mass Spectrometry Studies
- Medicinal Plants and Bioactive Compounds
- Cancer-related Molecular Pathways
Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies
2016-2025
National Research Council
2003-2025
National Research Council
2022
Ricerca sul Sistema Energetico (Italy)
1993-2001
University of Bari Aldo Moro
1995
Abstract To gain some insight into the mechanisms by which plant cells die as a result of abiotic stress, we exposed tobacco (Nicotiana tabacum) Bright-Yellow 2 to heat shock and investigated cell survival function time after induction. Heat treatment at 55°C triggered processes leading programmed death (PCD) that was complete 72 h. In early phase, undergoing PCD showed an immediate burst in hydrogen peroxide (H2O2) superoxide (O2 ·-) anion production. Consistently, prevented antioxidants...
To gain some insight into the mechanism of plant programmed cell death, certain features cytochrome c (cyt c) release were investigated in heat-shocked tobacco (Nicotiana tabacum) Bright-Yellow 2 cells 2- to 6-h time range. We found that h after heat shock, cyt is released from intact mitochondria cytoplasm as a functionally active protein. Such did not occur presence superoxide anion dismutase and catalase, thus showing it depends on reactive oxygen species (ROS). Interestingly, ROS...
DS (Down's syndrome) is the most common human aneuploidy associated with mental retardation and early neurodegeneration. Mitochondrial dysfunction has emerged as a crucial factor in pathogenesis of numerous neurological disorders including DS, but cause mitochondrial damage remains elusive. In present study, we identified new molecular events involved which could play role pathogenesis. We analysed respiratory chain function DS-HSFs syndrome foetal skin fibroblasts; fibroblasts chromosome 21...
The development of digital technologies and the evolution open innovation approaches have enabled creation diverse virtual organizations enterprises coordinating their activities primarily online. platform titled "International Natural Product Sciences Taskforce" (INPST) was established in 2018, to bring together collaborative environment individuals interested natural product scientific research, empower interactions by using communication tools.In this work, we present a general overview...
Down syndrome (DS) is caused by the presence of a supernumerary copy human chromosome 21 (Hsa21) and most frequent genetic cause intellectual disability (ID). Key traits DS are distinctive facies cognitive impairment. We conducted for first time an analysis Nuclear Magnetic Resonance (NMR)-detectable part metabolome in plasma urine samples, studying 67 subjects with 29 normal as controls selected among siblings. Multivariate NMR metabolomic profiles showed clear discrimination (up to 80%...
A central role for mitochondrial dysfunction has been proposed in the pathogenesis of DS (Down's syndrome), a multifactorial disorder caused by trisomy human chromosome 21. To explore whether and how abnormalities energy metabolism are involved pathogenesis, we investigated catalytic properties, gene expression protein levels certain proteins ATP synthesis, such as F1F0-ATPase, ANT (adenine nucleotide translocator) AK (adenylate kinase), DS-HSF (human skin fibroblasts with trisomic...