A5101934280- Peptidase Inhibition and Analysis
- Neuropeptides and Animal Physiology
- Structural Analysis and Optimization
- Protease and Inhibitor Mechanisms
- Plant tissue culture and regeneration
- Plant Virus Research Studies
- Chromosomal and Genetic Variations
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Advanced Materials and Mechanics
- GABA and Rice Research
- Signaling Pathways in Disease
- Advanced Nanomaterials in Catalysis
- Diabetes Treatment and Management
- Plant Molecular Biology Research
- Plant Disease Management Techniques
- Transgenic Plants and Applications
- Enzyme Production and Characterization
- Single-cell and spatial transcriptomics
- Biochemical and Structural Characterization
- Protein Hydrolysis and Bioactive Peptides
- Salivary Gland Tumors Diagnosis and Treatment
- Health, Environment, Cognitive Aging
- Metabolomics and Mass Spectrometry Studies
- Wheat and Barley Genetics and Pathology
Westlake University
2025
Center for Excellence in Molecular Cell Science
2025
ShanghaiTech University
2025
Chinese Academy of Sciences
2025
Zhejiang University
2018-2024
Huazhong Agricultural University
2022-2024
Zhejiang University of Technology
2023
Taian City Central Hospital
2023
Qingdao University
2023
Peking University People's Hospital
2022
Abstract Background Centromeres are critical for maintaining genomic stability in eukaryotes, and their turnover shapes genome architectures drives karyotype evolution. However, the co-evolution of centromeres from different species allopolyploids over millions years remains largely unknown. Results Here, we generate three near-complete assemblies, a tetraploid Brachypodium hybridum its two diploid ancestors, distachyon stacei . We detect high degrees sequence, structural, epigenetic...
Abstract Centromeres (CEN) are the chromosomal regions that play a crucial role in maintaining genomic stability. The underlying highly repetitive DNA sequences can evolve quickly most eukaryotes, and promote karyotype evolution. Despite their variability, it is not fully understood how these widely variable ensure homeostasis of centromere function. In this study, we investigated genetics epigenetics CEN population wheat lines from global breeding programs. We captured high degree...
Dipeptidyl Peptidase (DPP) 4 and related dipeptidyl peptidases are emerging as current potential therapeutic targets. DPP9 is an intracellular protease that regulated by redox status SUMO1. can influence antigen processing, epidermal growth factor (EGF)-mediated signaling tumor biology. We made the first gene knock-in (gki) mouse with a serine to alanine point mutation at active site (S729A). Weaned heterozygote DPP9wt/S729A pups from 110 intercrosses were indistinguishable wild-type...
To investigate the expression of dipeptidyl peptidase (DPP) 8 and DPP9 in lymphocytes various models liver fibrosis.DPP8 were measured mouse splenic CD4⁺ T-cells, CD8⁺ T-cells B-cells (B220⁺), human lymphoma cell lines splenocytes stimulated with pokeweed mitogen (PWM) or lipopolysaccharide (LPS), dithiothreitol (DTT) mitomycin-C treated Raji cells. DPP8 epidermal growth factor (EGF) Huh7 hepatoma cells, fibrotic samples from mice carbon tetrachloride (CCl₄) multidrug resistance gene 2...
Proteases catalyse irreversible posttranslational modifications that often alter a biological function of the substrate. The protease dipeptidyl peptidase 4 (DPP4) is pharmacological target in type 2 diabetes therapy primarily because it inactivates glucagon-like protein-1. DPP4 also has roles steatosis, insulin resistance, cancers and inflammatory fibrotic diseases. In addition, binds to spike protein MERS virus, causing be human cell surface receptor for virus. been identified as potential...
The treatment of ovarian cancer has not significantly changed in decades and it remains one the most lethal malignancies women. serine protease dipeptidyl peptidase 4 (DPP4) plays key roles metabolism immunity, its expression been associated with either pro- or anti-tumour effects multiple tumour types. In this study, we provide first evidence that DPP4 enzyme activity are uncoupled under hypoxic conditions cells. Whilst identified strong up-regulation mRNA growth, specific secreted was...
Grafting-induced variations have been observed in many plant species, but the heritability of variation progeny is not well understood. In our study, adventitious shoots from C cell lineage shoot apical meristem (SAM) grafting chimera TCC (where origin outmost, middle and innermost layers, respectively, SAM designated by 'T' for tuber mustard 'C' red cabbage) were induced identified as r-CCC (r = regenerated). To investigate maintenance during propagation regeneration, different generations...
Abstract Objective To study the factors associated with premenstrual syndrome (PMS) in emergency department (ED) nurses. Methods A multicenter cross-sectional was conducted female ED nurses China. Data gathering questionnaires included Daily Record of Severity Problems, Chinese Nurses Stressor Scale, Social Support Rating and Self-Rating Anxiety Scale. All were used to assess symptoms prospectively over 2 months. Results total 289 recruited. The incidence PMS 67.47%. most common tiredness...
Proteases catalyse irreversible posttranslational modifications that often alter a biological function of the substrate. The protease dipeptidyl peptidase 4 (DPP4) is pharmacological target in type 2 diabetes therapy primarily because it inactivates glucagon-like protein-1. DPP4 also has roles steatosis, insulin resistance, cancers and inflammatory fibrotic diseases. In addition, binds to spike protein MERS virus, causing be human cell surface receptor for virus. been identified as potential...
Abstract Agrobacterium–mediated transformation is a cost-effective and convenient way to introduce foreign genetic elements plants. However, only limited protocols successfully generates transgenic plants with fielder, spring wheat variety. Wheat method higher efficiency without genotype restriction heavily demanded. Here, heat-shock protocol, independent of Japan Tobacco had been established. Transgenic can be obtained from immature embryo within 60 days by this protocol. Morphogenic...