A5019060738- Pain Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Pain Management and Placebo Effect
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Myofascial pain diagnosis and treatment
- Endometriosis Research and Treatment
- Infrared Thermography in Medicine
- Anesthesia and Pain Management
- Pain Management and Treatment
- Menstrual Health and Disorders
- Transcranial Magnetic Stimulation Studies
- Ion Channels and Receptors
- Pregnancy-related medical research
- Psychosomatic Disorders and Their Treatments
- Engineering Technology and Methodologies
- Botulinum Toxin and Related Neurological Disorders
- Global Health and Surgery
- Healthcare professionals’ stress and burnout
- Psychological Treatments and Assessments
- Advanced Scientific Research Methods
- Radiomics and Machine Learning in Medical Imaging
- Heart Rate Variability and Autonomic Control
- Educational and Psychological Assessments
- Cardiac, Anesthesia and Surgical Outcomes
- Biomedical and Chemical Research
University of Bern
2009-2023
University Hospital of Bern
2008-2017
Kantonsspital Winterthur
2015
University of St. Gallen
2013-2014
Aalborg University
2013
Institute of Social and Preventive Medicine
2013
Schulthess-Klinik
2013
University of London
2011
SOAS University of London
2011
Abstract Quantitative sensory tests are widely used in human research to evaluate the effect of analgesics and explore altered pain mechanisms, such as central sensitization. In order apply these clinical practice, knowledge reference values is essential. The aim this study was determine thresholds for mechanical thermal stimuli, well withdrawal time cold pressor test 300 pain‐free subjects. Pain detection tolerance pressure, heat were determined at three body sites: (1) lower back, (2)...
During the last decade, a multi-modal approach has been established in human experimental pain research for assessing thresholds and responses to various modalities. Studies have concluded that differences stimuli are mainly related variation between individuals rather than response different stimulus In factor analysis of 272 consecutive volunteers (137 men 135 women) who underwent tests with modalities, it was determined whether modalities represent distinct individual uncorrelated...
Low back pain is associated with plasticity changes and central hypersensitivity in a subset of patients. We performed case-control study to explore the discriminative ability different quantitative sensory tests distinguishing between 40 cases chronic low 300 pain-free controls, rank these according extent their association pain. Gender, age, height, weight, body mass index, psychological measures were recorded as potential confounders. used 26 tests, including modalities pressure, heat,...
Disturbed endogenous pain modulation is likely one of the mechanisms underlying central hypersensitivity and might be a contributing factor for development maintenance chronic pain. To our knowledge, no study has investigated in both acute low back (LBP). We tested hypothesis that inhibition impaired patients with LBP.We evaluated 40 LBP, 34 LBP 30 pain-free controls their conditioned (CPM), pressure tolerance cold pressor as test conditioning stimulus, respectively. Measurements were...
Assessments of spinal nociceptive withdrawal reflexes can be used in human research both to evaluate the effect analgesics and explore pain mechanisms related sensitization. Before reflex as a clinical tool, normative values need determined large scale studies. The aim this study was determine reference subjective thresholds (to single repeated stimulation), area receptive fields (RRF) 300 pain-free volunteers. influences gender, age, height, weight, body-mass index (BMI), body side testing,...
Widespread central hypersensitivity is present in chronic pain and contributes to disability. According animal studies, expansion of receptive fields spinal cord neurons involved hypersensitivity. We recently developed a method quantify nociceptive humans using withdrawal reflexes. Here we hypothesized that patients with pelvic display enlarged reflex fields. Secondary endpoints were subjective thresholds after single repeated (temporal summation) electrical stimulation. 20 25 pain-free...
Pain hypersensitivity has been consistently detected in chronic pain conditions, but the underlying mechanisms are difficult to investigate humans and thus poorly understood. Patients with endometriosis display enlarged reflex receptive fields (RRF), providing a new perspective identification of possible behind states humans. The primary hypothesis this study was that RRF patients musculoskeletal pain. Secondary end points were subjective thresholds nociceptive withdrawal (NWR) after single...
Hypersensitivity of pain pathways is considered a relevant determinant symptoms in chronic patients, but data on its prevalence are very limited. To our knowledge, no the spinal nociceptive hypersensitivity available. We studied and 961 consecutive patients with various conditions. Pain threshold withdrawal reflex to electrical stimulation were used assess hypersensitivity, respectively. Using 10th percentile cutoff previously determined reference values, (95% confidence interval) was 71.2...
Abstract Background It would be desirable to identify patients with acute low back pain (ALBP) who are at high risk for transition chronic early in the course of their disease. This enable preventive or therapeutic interventions. Patients (CLBP) display signs central hypersensitivity. may contribute CLBP. We tested hypothesis that hypersensitivity as assessed by quantitative sensory tests predicts Methods performed a prospective cohort study 130 ALBP recruited primary care setting determine...
The activation of 5-hydroxytryptamine-3 (5-HT-3) receptors in spinal cord can enhance intrinsic mechanisms central hypersensitivity, possibly leading to exaggerated pain responses. Clinical studies suggest that 5-HT-3 receptor antagonists may have an analgesic effect. This randomized, double-blind, placebo-controlled crossover study tested the hypothesis antagonist tropisetron attenuates and hypersensitivity patients with chronic low back pain. Thirty pain, 15 whom were women (aged 53 ± 14...
<h3>Background and Objectives</h3> Quantitative sensory testing (QST) is widely used to investigate peripheral central sensitization. However, the comparative performance of different QST for diagnostic or prognostic purposes unclear. We explored discriminative ability quantitative tests in distinguishing between patients with chronic neck pain pain-free control subjects ranked these according extent their association hypersensitivity. <h3>Methods</h3> performed a case-control study 40 300...
<h3>Abstract</h3> Translational research has not yet elucidated whether alterations in central pain processes are related to peripheral inflammatory chronic patients. We tested the hypothesis that concentration of cytokines peritoneal fluid endometriosis patients with correlate parameters hyperexcitability nociceptive system. The concentrations 15 were measured 11 pelvic and a diagnosis endometriosis. Six assessing recorded. Positive correlations between some amplification processing found....

 The 30th Albanian Surgical Conference (ACS 2023) and the 7th Congress of Trauma Emergency Surgery (ACTES represent a significant milestone in medical community. These concurrent events provide platform for exchange knowledge, collaboration, advancement surgical science Albania.
 ACS 2023 & ACTES gather experts, scholars, practitioners, enthusiasts from field surgery, both traumatic non-traumatic areas, vibrant city Tirana. comprehensive program encompasses diverse range...