A5038523840- Musculoskeletal pain and rehabilitation
- Pain Mechanisms and Treatments
- Anesthesia and Pain Management
- Spine and Intervertebral Disc Pathology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pain Management and Placebo Effect
- Pain Management and Opioid Use
- Anesthesia and Sedative Agents
- Nausea and vomiting management
- Myofascial pain diagnosis and treatment
- Pain Management and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Pediatric Pain Management Techniques
- Shoulder Injury and Treatment
- Opioid Use Disorder Treatment
- Kidney Stones and Urolithiasis Treatments
- Nerve Injury and Rehabilitation
- Botulinum Toxin and Related Neurological Disorders
- Peripheral Nerve Disorders
- Ureteral procedures and complications
- Treatment of Major Depression
- Dental Anxiety and Anesthesia Techniques
- Pregnancy-related medical research
- Pesticide Residue Analysis and Safety
- Advanced Materials and Mechanics
University of Washington
2016-2025
Pain and Rehabilitation Medicine
2000-2024
Seattle University
2013-2024
Roma Tre University
2024
Harborview Injury Prevention and Research Center
2019-2023
Aalborg University
2014-2023
Washington Center
2022-2023
University of Washington Medical Center
2023
Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna "Bruno Ubertini"
1996-2022
University of Bern
2005-2019
Patients with chronic pain after whiplash injury and fibromyalgia patients display exaggerated sensory stimulation. Because evident tissue damage is usually lacking, this perception could be explained by hyperexcitability of the central nervous system. The nociceptive withdrawal reflex (a spinal reflex) may used to study excitability state cord neurons. We tested hypothesis that facilitated therefore hypersensitivity. Three groups were studied: (n=27), (n=22) healthy controls (n=29). Two...
Objective The mechanisms underlying chronic pain after whiplash injury are usually unclear. Injuries may cause sensitization of spinal cord neurons in animals (central hypersensitivity), which results increased responsiveness to peripheral stimuli. In humans, the central nervous system stimulation be explored by applying sensory tests healthy tissues. hypotheses this study were: (1) is associated with hypersensitivity; (2) hypersensitivity maintained nociception arising from painful or...
From folk medicine and anecdotal reports it is known that Cannabis may reduce pain. In animal studies has been shown delta-9-tetrahydrocannabinol (THC) antinociceptive effects or potentiates the effect of morphine. The aim this study was to measure analgesic THC, morphine, a THC-morphine combination (THC-morphine) in humans using experimental pain models. THC (20 mg), morphine (30 mg THC+30 morphine), placebo were given orally as single doses. Twelve healthy volunteers included randomized,...
<h3>Background and Objectives:</h3> Nerve blocks using local anesthetics are widely used. High volumes usually injected, which may predispose patients to associated adverse events. Introduction of ultrasound guidance facilitates the reduction volume, but minimal effective volume is unknown. In this study, we estimated 50% dose (ED<sub>50</sub>) 95% (ED<sub>95</sub>) 1% mepivacaine relative cross-sectional area nerve for an adequate sensory block. <h3>Methods:</h3> To reduce number healthy...
In Brief BACKGROUND: Calcitonin was effective in a study of acute phantom limb pain, but it not studied the chronic phase. The overall literature on N-methyl-d-aspartate antagonists is equivocal. We tested hypothesis that calcitonin, ketamine, and their combination are treating pain. Our secondary aim to improve our understanding mechanisms action investigated drugs using quantitative sensory testing. METHODS: Twenty patients received, randomized, double-blind, crossover manner, 4 IV...
During the last decade, a multi-modal approach has been established in human experimental pain research for assessing thresholds and responses to various modalities. Studies have concluded that differences stimuli are mainly related variation between individuals rather than response different stimulus In factor analysis of 272 consecutive volunteers (137 men 135 women) who underwent tests with modalities, it was determined whether modalities represent distinct individual uncorrelated...
<h3>Background and Objectives</h3> The suprascapular nerve (SSN) block is frequently performed for different shoulder pain conditions perioperative postoperative control after surgery. Blind image-guided techniques have been described, all of which target the within supraspinous fossa or at notch. This classic point not always ideal when ultrasound (US) used because it located deep under muscles, hence visible. Blocking in supraclavicular region, where passes underneath omohyoid muscle,...
Classification of musculoskeletal pain based on underlying mechanisms (nociceptive, neuropathic, and nociplastic pain) is challenging. In the absence a gold standard, verification features that could aid in discrimination between these clinical practice research depends expert consensus. This Delphi consensus study aimed to: (1) identify assessment findings are unique to mechanism category or shared no more than 2 categories (2) develop ranked list candidate potentially discriminate...
We developed prediction models for severe pain and urinary symptoms after ureteroscopy with ureteral stent placement. The development cohort included 424 adults adolescents enrolled in the multicenter STENTS prospective study who underwent placement stones. validation was an independent of 115 adults. outcomes were intensity interference, measured by Patient-Reported Outcomes Measurement Information System, symptoms, Ureteral Stent Symptom Questionnaire. top quartile on postoperative days 1...
Background Chronic neck pain after whiplash injury is caused by cervical zygapophysial joints in 50% of patients. Diagnostic blocks nerves supplying the are performed using fluoroscopy. The authors' hypothesis was that third occipital nerve can be visualized and blocked with use an ultrasound-guided technique. Methods In 14 volunteers, authors placed a needle to on both sides neck. They punctured caudal perpendicular 14-MHz transducer. 11 0.9 ml either local anesthetic or normal saline...
Chronic pain after whiplash injury is associated with hypersensitivity of the central nervous system to peripheral stimulation. It unclear whether modulated by nociceptive input. We hypothesized that changes in input would correlate magnitude hypersensitivity.Fifteen patients chronic were investigated. Changes induced infiltration painful and tender muscles bupivacaine (0.25%). Such infiltrations produce either reduction or enhancement, latter effect probably resulting from transient...
Sensory hypersensitivity, central hyperexcitability [lowered nociceptive flexion reflex (NFR) thresholds], and psychologic distress are features of chronic whiplash. However, relationships between these substrates not clear. This study tested the hypothesis that catastrophization correlated with sensory hypersensitivity NFR responses in whiplash.Pressure thermal pain thresholds (mean values across 3 body sites), threshold, at threshold Visual Analog Scale were measured 30 participants...
Low back pain is associated with plasticity changes and central hypersensitivity in a subset of patients. We performed case-control study to explore the discriminative ability different quantitative sensory tests distinguishing between 40 cases chronic low 300 pain-free controls, rank these according extent their association pain. Gender, age, height, weight, body mass index, psychological measures were recorded as potential confounders. used 26 tests, including modalities pressure, heat,...
The aim of this study was to determine the reliability conditioned pain modulation (CPM) paradigm assessed by an objective electrophysiological method, nociceptive withdrawal reflex (NWR), and psychophysical measures, using hypothetical sample sizes for future studies as analytical goals. Thirty-four healthy volunteers participated in two identical experimental sessions, separated 1 3 weeks. In each session, cold pressor test (CPT) used induce CPM, NWR thresholds, electrical detection...
Disturbed endogenous pain modulation is likely one of the mechanisms underlying central hypersensitivity and might be a contributing factor for development maintenance chronic pain. To our knowledge, no study has investigated in both acute low back (LBP). We tested hypothesis that inhibition impaired patients with LBP.We evaluated 40 LBP, 34 LBP 30 pain-free controls their conditioned (CPM), pressure tolerance cold pressor as test conditioning stimulus, respectively. Measurements were...