A5011936951- Circular RNAs in diseases
- MicroRNA in disease regulation
- Diabetes Treatment and Management
- Hedgehog Signaling Pathway Studies
- Glioma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Diabetes Management and Research
- BRCA gene mutations in cancer
- Oral and gingival health research
- Radiomics and Machine Learning in Medical Imaging
- Health Systems, Economic Evaluations, Quality of Life
- Multiple and Secondary Primary Cancers
- Estrogen and related hormone effects
- Chronic Disease Management Strategies
- TGF-β signaling in diseases
- Colorectal and Anal Carcinomas
- Retinoids in leukemia and cellular processes
- Cancer-related Molecular Pathways
- Pleural and Pulmonary Diseases
- Extracellular vesicles in disease
- Pericarditis and Cardiac Tamponade
- Genomics and Chromatin Dynamics
- Diabetes, Cardiovascular Risks, and Lipoproteins
Sapienza University of Rome
2020-2025
Nottingham University Hospitals NHS Trust
2020
Université Paris Sciences et Lettres
2017-2018
Centre National de la Recherche Scientifique
2017-2018
Institut Curie
2017-2018
Sorbonne Université
2018
Dynamique de l'information génétique : bases fondamentales et cancer
2018
Federico II University Hospital
2012-2013
Istituto di Farmacologia Traslazionale
2010
Colorectal cancer (CRC) is a leading cause of death. Chemoresistance pivotal feature cells to treatment failure and ATP-binding cassette (ABC) transporters are responsible for the efflux several molecules, including anticancer drugs. The Hedgehog-GLI (HH-GLI) pathway major signalling in CRC, however its role chemoresistance has not been fully elucidated. Here we show that HH-GLI favours resistance 5-fluorouracil Oxaliplatin CRC cells. We identified potential GLI1 binding sites promoter...
Colorectal cancer (CRC) is a leading cause of cancer-related mortality and chemoresistance major medical issue. The epithelial-to-mesenchymal transition (EMT) the primary step in emergence invasive phenotype Hedgehog-GLI (HH-GLI) NOTCH signaling pathways are associated with poor prognosis EMT CRC. CRC cell lines harboring KRAS or BRAF mutations, grown as monolayers organoids, were treated chemotherapeutic agent 5-Fluorouracil (5-FU) alone combined HH-GLI pathway inhibitors GANT61 DAPT,...
Histone H3K4 methylation is a feature of meiotic recombination hotspots shared by many organisms including plants and mammals. Meiotic initiated programmed double-strand break (DSB) formation that in budding yeast takes place gene promoters promoted histone di/trimethylation. This modification recognized Spp1, PHD finger containing protein belongs to the conserved methyltransferase Set1 complex. During meiosis, Spp1 binds H3K4me3 interacts with DSB protein, Mer2, promote close promoters. How...
The antidiabetic sodium-glucose cotransporter type 2 inhibitor (SGLT2i) empagliflozin efficiently reduces heart failure (HF) hospitalization and cardiovascular death in diabetes (T2D). Empagliflozin-cardioprotection likely includes anti-inflammatory effects, regardless glucose lowering, but the underlying mechanisms remain unclear. Inflammation is a primary event diabetic cardiomyopathy (DCM) HF development. interferon (IFN)γ-induced 10-kDa protein (IP-10/CXCL10), T helper 1 (Th1)-type...
Abstract Purpose/methods The determination of tumour biomarkers is paramount to advancing personalized medicine, more so in rare tumours like medullary thyroid carcinoma (MTC), whose diagnosis still challenging. aim this study was identify non-invasive circulating MTC. To achieve goal, paired MTC tissue and plasma extracellular vesicle samples were collected from multiple centres microRNA (miRNA) expression levels evaluated. Results a discovery cohort 23 patients analysed using miRNA arrays....
Pericardial malignant mesothelioma (MM) is a rare tumour which accounts for about 1% of all mesotheliomas, 4% the primary heart and pericardial tumours. It carries an extremely poor prognosis, with reported overall survival less than 6 months. Clinical symptoms signs are frequently nonspecific, diagnosis usually made after surgery or at autopsy. We report case 72 years old woman involving right atrium. Nine months following surgery, patient alive good performance status.
Medullary thyroid carcinoma (MTC) is a malignant tumor with challenging management. Multi-targeted kinase inhibitors (MKI) and tyrosine-kinase (TKI) high specificity for RET protein are approved advanced MTC treatment. However, their efficacy hindered by evasion mechanisms of cells. Thus, the aim this study was identification an escape mechanism in cells exposed to highly selective TKI. TT were treated TKI, MKI, and/or HH-Gli inhibitors, GANT61 Arsenic Trioxide (ATO), presence or absence...
Abstract Background Pediatric low-grade gliomas (pLGGs), particularly incompletely resected supratentorial tumours, can undergo progression after surgery. However to date, there are no predictive biomarkers for progression. Here, we aimed identify pLGG-specific microRNA signatures and evaluate their value as a prognostic tool. Methods We identified validated incompletey microRNAs in independent cohorts from four European Neuro-Oncology Centres. Results These demonstrated high accuracy...
In this study we compare the cost-effectiveness of saxagliptin (Onglyza®) in combination with metformin to that either sulphonylurea (SU) plus or a thiazolidinedione (TZD) metformin, type 2 diabetes mellitus patients who are not well-controlled on alone. By using decision-analytic modeling, long-term costs and health outcomes associated investigated treatment strategies estimated. This is achieved by modeling risk experiencing diabetes-related events (e.g. myocardial infarction) side-effects...
Abstract Histone H3K4 methylation is a feature of meiotic recombination hotspots shared by many organisms including plants and mammals. Meiotic initiated programmed double-strand break (DSB) formation that in budding yeast takes place gene promoters promoted histone di/trimethylation. This modification recognized Spp1, PHD-finger containing protein belongs to the conserved methyltransferase Set1 complex. During meiosis, Spp1 binds H3K4me3 interacts with DSB protein, Mer2, promote close...