A5084365072- Tuberculosis Research and Epidemiology
- Cancer Cells and Metastasis
- Mesenchymal stem cell research
- interferon and immune responses
- Salivary Gland Disorders and Functions
- Systemic Lupus Erythematosus Research
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Atherosclerosis and Cardiovascular Diseases
Stony Brook University
2022
University of California, San Francisco
2022
Abstract The epidemiology of infectious causes meningitis in sub-Saharan Africa is not well understood, and a common cause this region, Mycobacterium tuberculosis (TB), notoriously hard to diagnose. Here we show that integrating cerebrospinal fluid (CSF) metagenomic next-generation sequencing (mNGS) with host gene expression-based machine learning classifier (MLC) enhances diagnostic accuracy for TB (TBM) its mimics. 368 HIV-infected Ugandan adults subacute were prospectively enrolled. Total...
Abstract In the general human population, aging is associated with a rise in systemic inflammation, primarily involving innate immune pathways related to interferon (IFN), toll-like receptor, and cytokine signaling. lupus erythematosus (SLE), prototypical autoimmune disease, distinctly improvements disease activity, suggesting unique relationship between inflammation this disease. Using multi-omic approach incorporating transcriptional profiling, single cell RNA sequencing, proteomics...
Predicting mortality risk in patients with COVID-19 remains challenging, and accurate prognostic assays represent a persistent unmet clinical need. We aimed to identify validate parsimonious transcriptomic signatures that accurately predict fatal outcomes within 48 hours of hospitalization. studied 894 hospitalized for across 20 US hospitals enrolled the prospective Immunophenotyping Assessment Cohort (IMPACC) peripheral blood mononuclear cells (PBMC) nasal swabs collected admission. Host...
Salivary gland (SG) stem cells are the only cell population capable of extended growth in organotypic cultures, and thus they considered a source for cell-based therapies aimed at SG regeneration. Studies mouse submandibular have identified one tissue salisphere formation culture. These actively dividing ductal that express epithelial progenitor markers keratin (K) 5/14 normally function as lineage-restricted differentiated cells. In response to severe injury, however, these undergo...